15‐hydroxy‐eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator‐activated receptor gamma‐dependent pathway

Peroxisome proliferator‐activated receptor gamma (PPARγ) inhibits cell growth via promoting apoptosis. Human colorectal cancer tissues had abundant PPARγ but the incidence of apoptosis was very low, suggesting a defect in the PPARγ pathway. Here, we found that 15‐hydroxy‐eicosatetraenoic acid (15S‐H...

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Veröffentlicht in:	International journal of cancer 2003-12, Vol.107 (5), p.837-843
Hauptverfasser:	Chen, George G., Xu, Hu, Lee, Janet F.Y., Subramaniam, Malayannan, Leung, Ka L., Wang, Su H., Chan, Ursula P.F., Spelsberg, Thomas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	15‐hydroxy‐eicosatetraenoic acid 15‐lipoxygenase Apoptosis - drug effects Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Colonic Neoplasms - pathology colorectal carcinoma DNA-Binding Proteins - metabolism Early Growth Response Transcription Factors Gastroenterology. Liver. Pancreas. Abdomen Humans Hydroxyeicosatetraenoic Acids - pharmacology Immunohistochemistry Kruppel-Like Transcription Factors Lipoxygenase - metabolism Medical sciences peroxisome proliferator‐activated receptor gamma Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology Recombinant Proteins - drug effects Rectal Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus TGF‐β‐inducible early gene and Bcl‐2 Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transfection Tumor Cells, Cultured Tumors
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