Prognostic Value of Myeloperoxidase in Patients with Chest Pain
Inflammation appears to have a key role in acute coronary syndromes. Myeloperoxidase, an enzyme that generates reactive oxygen species, is released from leukocytes on activation, and plasma levels of myeloperoxidase may serve as a marker of inflammation. In this study, plasma myeloperoxidase levels...
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| Veröffentlicht in: | The New England journal of medicine 2003-10, Vol.349 (17), p.1595-1604 |
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| creator | Brennan, Marie-Luise Penn, Marc S Van Lente, Frederick Nambi, Vijay Shishehbor, Mehdi H Aviles, Ronnier J Goormastic, Marlene Pepoy, Michael L McErlean, Ellen S Topol, Eric J Nissen, Steven E Hazen, Stanley L |
| description | Inflammation appears to have a key role in acute coronary syndromes. Myeloperoxidase, an enzyme that generates reactive oxygen species, is released from leukocytes on activation, and plasma levels of myeloperoxidase may serve as a marker of inflammation. In this study, plasma myeloperoxidase levels were found to be predictive of subsequent coronary events in patients with chest pain, even when patients were initially negative for troponin T.
Plasma levels had predictive value in patients with chest pain.
Coronary thrombosis results in serious adverse cardiac events, even in the presence of aggressive intervention and treatment.
1
–
3
Levels of creatine kinase isoenzymes and cardiac troponins, which are diagnostic biologic markers of myocardial necrosis, are used either alone or in conjunction with levels of C-reactive protein as prognostic indicators of myocardial infarction.
4
,
5
Many patients with chest pain have normal levels of creatine kinase isoenzymes or troponins at presentation but subsequently have a myocardial infarction, require revascularization, or die within six months. Additional biochemical measures, ideally based on the pathophysiology of plaque vulnerability, are needed.
Inflammation has been linked to . . . |
| doi_str_mv | 10.1056/NEJMoa035003 |
| format | Article |
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Plasma levels had predictive value in patients with chest pain.
Coronary thrombosis results in serious adverse cardiac events, even in the presence of aggressive intervention and treatment.
1
–
3
Levels of creatine kinase isoenzymes and cardiac troponins, which are diagnostic biologic markers of myocardial necrosis, are used either alone or in conjunction with levels of C-reactive protein as prognostic indicators of myocardial infarction.
4
,
5
Many patients with chest pain have normal levels of creatine kinase isoenzymes or troponins at presentation but subsequently have a myocardial infarction, require revascularization, or die within six months. Additional biochemical measures, ideally based on the pathophysiology of plaque vulnerability, are needed.
Inflammation has been linked to . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa035003</identifier><identifier>PMID: 14573731</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Aged ; Angina pectoris ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cardiovascular disease ; Chest Pain - enzymology ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - enzymology ; Coronary heart disease ; Coronary Thrombosis - blood ; Coronary Thrombosis - diagnosis ; Coronary Thrombosis - enzymology ; Coronary vessels ; Creatine Kinase - blood ; Creatine Kinase, MB Form ; Female ; Heart ; Heart attacks ; Humans ; Isoenzymes - blood ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction ; Myocardial Revascularization ; Peroxidase - blood ; Prognosis ; Risk ; Troponin T - blood</subject><ispartof>The New England journal of medicine, 2003-10, Vol.349 (17), p.1595-1604</ispartof><rights>Copyright © 2003 Massachusetts Medical Society. All rights reserved.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-7d45e8fce8b236a9846e256739eb965c42965f54b06911b8c22982f912c8a42d3</citedby><cites>FETCH-LOGICAL-c502t-7d45e8fce8b236a9846e256739eb965c42965f54b06911b8c22982f912c8a42d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa035003$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223926454?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15225859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14573731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brennan, Marie-Luise</creatorcontrib><creatorcontrib>Penn, Marc S</creatorcontrib><creatorcontrib>Van Lente, Frederick</creatorcontrib><creatorcontrib>Nambi, Vijay</creatorcontrib><creatorcontrib>Shishehbor, Mehdi H</creatorcontrib><creatorcontrib>Aviles, Ronnier J</creatorcontrib><creatorcontrib>Goormastic, Marlene</creatorcontrib><creatorcontrib>Pepoy, Michael L</creatorcontrib><creatorcontrib>McErlean, Ellen S</creatorcontrib><creatorcontrib>Topol, Eric J</creatorcontrib><creatorcontrib>Nissen, Steven E</creatorcontrib><creatorcontrib>Hazen, Stanley L</creatorcontrib><title>Prognostic Value of Myeloperoxidase in Patients with Chest Pain</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Inflammation appears to have a key role in acute coronary syndromes. Myeloperoxidase, an enzyme that generates reactive oxygen species, is released from leukocytes on activation, and plasma levels of myeloperoxidase may serve as a marker of inflammation. In this study, plasma myeloperoxidase levels were found to be predictive of subsequent coronary events in patients with chest pain, even when patients were initially negative for troponin T.
Plasma levels had predictive value in patients with chest pain.
Coronary thrombosis results in serious adverse cardiac events, even in the presence of aggressive intervention and treatment.
1
–
3
Levels of creatine kinase isoenzymes and cardiac troponins, which are diagnostic biologic markers of myocardial necrosis, are used either alone or in conjunction with levels of C-reactive protein as prognostic indicators of myocardial infarction.
4
,
5
Many patients with chest pain have normal levels of creatine kinase isoenzymes or troponins at presentation but subsequently have a myocardial infarction, require revascularization, or die within six months. Additional biochemical measures, ideally based on the pathophysiology of plaque vulnerability, are needed.
Inflammation has been linked to . . .</description><subject>Aged</subject><subject>Angina pectoris</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Chest Pain - enzymology</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - enzymology</subject><subject>Coronary heart disease</subject><subject>Coronary Thrombosis - blood</subject><subject>Coronary Thrombosis - diagnosis</subject><subject>Coronary Thrombosis - enzymology</subject><subject>Coronary vessels</subject><subject>Creatine Kinase - blood</subject><subject>Creatine Kinase, MB Form</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Isoenzymes - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction</subject><subject>Myocardial Revascularization</subject><subject>Peroxidase - blood</subject><subject>Prognosis</subject><subject>Risk</subject><subject>Troponin T - blood</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0M9LwzAUB_AgipvTm2cpop6s5mebnETG_MWmO6jXkqapZrTNTFp0_72RFSZiDi_w-PBe8gXgEMELBFly-Th5mFkJCYOQbIEhYoTElMJkGwwhxDymqSADsOf9AoaDqNgFA0RZSlKChuBq7uxbY31rVPQqq05HtoxmK13ZpXb2yxTS68g00Vy2Rjetjz5N-x6N37VvQ880-2CnlJXXB_09Ai83k-fxXTx9ur0fX09jxSBu47SgTPNSaZ5jkkjBaaIxS1IidC4SpigOtWQ0h4lAKOcKY8FxKRBWXFJckBE4W89dOvvRhe1ZbbzSVSUbbTufpYiEz6UkwOM_cGE714S3ZRgTgRPKaEDna6Sc9d7pMls6U0u3yhDMflLNfqca-FE_s8trXWxwH2MApz2QXsmqdLJRxm8cw5hxJoI7Wbu69lmjF_X_-74BxoOH2w</recordid><startdate>20031023</startdate><enddate>20031023</enddate><creator>Brennan, Marie-Luise</creator><creator>Penn, Marc S</creator><creator>Van Lente, Frederick</creator><creator>Nambi, Vijay</creator><creator>Shishehbor, Mehdi H</creator><creator>Aviles, Ronnier J</creator><creator>Goormastic, Marlene</creator><creator>Pepoy, Michael L</creator><creator>McErlean, Ellen S</creator><creator>Topol, Eric J</creator><creator>Nissen, Steven E</creator><creator>Hazen, Stanley L</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20031023</creationdate><title>Prognostic Value of Myeloperoxidase in Patients with Chest Pain</title><author>Brennan, Marie-Luise ; Penn, Marc S ; Van Lente, Frederick ; Nambi, Vijay ; Shishehbor, Mehdi H ; Aviles, Ronnier J ; Goormastic, Marlene ; Pepoy, Michael L ; McErlean, Ellen S ; Topol, Eric J ; Nissen, Steven E ; Hazen, Stanley L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-7d45e8fce8b236a9846e256739eb965c42965f54b06911b8c22982f912c8a42d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Angina pectoris</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Chest Pain - enzymology</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - enzymology</topic><topic>Coronary heart disease</topic><topic>Coronary Thrombosis - blood</topic><topic>Coronary Thrombosis - diagnosis</topic><topic>Coronary Thrombosis - enzymology</topic><topic>Coronary vessels</topic><topic>Creatine Kinase - blood</topic><topic>Creatine Kinase, MB Form</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Isoenzymes - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction</topic><topic>Myocardial Revascularization</topic><topic>Peroxidase - blood</topic><topic>Prognosis</topic><topic>Risk</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brennan, Marie-Luise</creatorcontrib><creatorcontrib>Penn, Marc S</creatorcontrib><creatorcontrib>Van Lente, Frederick</creatorcontrib><creatorcontrib>Nambi, Vijay</creatorcontrib><creatorcontrib>Shishehbor, Mehdi H</creatorcontrib><creatorcontrib>Aviles, Ronnier J</creatorcontrib><creatorcontrib>Goormastic, Marlene</creatorcontrib><creatorcontrib>Pepoy, Michael L</creatorcontrib><creatorcontrib>McErlean, Ellen S</creatorcontrib><creatorcontrib>Topol, Eric J</creatorcontrib><creatorcontrib>Nissen, Steven E</creatorcontrib><creatorcontrib>Hazen, Stanley L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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Myeloperoxidase, an enzyme that generates reactive oxygen species, is released from leukocytes on activation, and plasma levels of myeloperoxidase may serve as a marker of inflammation. In this study, plasma myeloperoxidase levels were found to be predictive of subsequent coronary events in patients with chest pain, even when patients were initially negative for troponin T.
Plasma levels had predictive value in patients with chest pain.
Coronary thrombosis results in serious adverse cardiac events, even in the presence of aggressive intervention and treatment.
1
–
3
Levels of creatine kinase isoenzymes and cardiac troponins, which are diagnostic biologic markers of myocardial necrosis, are used either alone or in conjunction with levels of C-reactive protein as prognostic indicators of myocardial infarction.
4
,
5
Many patients with chest pain have normal levels of creatine kinase isoenzymes or troponins at presentation but subsequently have a myocardial infarction, require revascularization, or die within six months. Additional biochemical measures, ideally based on the pathophysiology of plaque vulnerability, are needed.
Inflammation has been linked to . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>14573731</pmid><doi>10.1056/NEJMoa035003</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland |
| subjects | Aged Angina pectoris Biological and medical sciences Biomarkers - blood C-Reactive Protein - analysis Cardiology. Vascular system Cardiovascular disease Chest Pain - enzymology Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - enzymology Coronary heart disease Coronary Thrombosis - blood Coronary Thrombosis - diagnosis Coronary Thrombosis - enzymology Coronary vessels Creatine Kinase - blood Creatine Kinase, MB Form Female Heart Heart attacks Humans Isoenzymes - blood Male Medical sciences Middle Aged Myocardial Infarction Myocardial Revascularization Peroxidase - blood Prognosis Risk Troponin T - blood |
| title | Prognostic Value of Myeloperoxidase in Patients with Chest Pain |
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