Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains

PolyI:C, a synthetic double-stranded (ds)RNA, and viruses act on cells to induce IFN-β which is a key molecule for anti-viral response. Although dsRNA is a virus-specific signature and a ligand for human Toll-like receptor 3 (TLR3), largely uncharacterized multiple pathways associate virus-mediated...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-11, Vol.311 (1), p.39-48
Hauptverfasser:	Tanabe, Masako, Kurita-Taniguchi, Mitsue, Takeuchi, Kaoru, Takeda, Makoto, Ayata, Minoru, Ogura, Hisashi, Matsumoto, Misako, Seya, Tsukasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Fibroblasts - immunology Fibroblasts - metabolism Fibroblasts - virology Humans IFN-α/β Interferon-beta - immunology Interferon-beta - metabolism ISRE Measles - immunology Measles - metabolism Measles virus Measles virus - classification Measles virus - immunology Measles virus - pathogenicity Membrane Glycoproteins - classification Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Receptors, Cell Surface - classification Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Respiratory Mucosa - virology Toll-Like Receptor 3 Toll-Like Receptors Transcriptional regulation Up-Regulation - physiology Vaccines, Attenuated
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