Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites
The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite-encoded proteins to the erythrocyte plasma membrane. Activation of G proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium hom...
Gespeichert in:
| Veröffentlicht in: | Blood 2003-11, Vol.102 (9), p.3420-3426 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3426 |
|---|---|
| container_issue | 9 |
| container_start_page | 3420 |
| container_title | Blood |
| container_volume | 102 |
| creator | Taraschi, Theodore F. O’Donnell, Megan Martinez, Sandra Schneider, Timothy Trelka, Darin Fowler, Velia M. Tilley, Leann Moriyama, Yoshinori |
| description | The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite-encoded proteins to the erythrocyte plasma membrane. Activation of G proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium homologues of COPII and N-ethylmaleimide-sensitive factor, proteins involved in intracellular transport between the Golgi apparatus and the endoplasmic reticulum. These vesicles contain malarial proteins that appear on the erythrocyte plasma membrane, as well as actin and myosin. It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane. |
| doi_str_mv | 10.1182/blood-2003-05-1448 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71299821</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006497120539475</els_id><sourcerecordid>71299821</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-3803dbf76ee71e9b7f1af0f8798de287964ef9e30ea1f432fda8a364a597ab623</originalsourceid><addsrcrecordid>eNp9kEtvFDEMgCMEokvhD3BAucBtII95JBIXVNGCVAkO7Tl4Mo4ImpkscbbS_Huy3ZV642Rb_mzZH2NvpfgopVGfxjmlqVFC6EZ0jWxb84ztZKdMI4QSz9lOCNE3rR3kBXtF9EcI2WrVvWQXUpnettbs2K8bXDFDiWnlKXBYOeat_M7JbwX5A1L0M_KSYaV9yoXTRgUXPm785wy0pCkeFh5g9nEPuaYLzJAj8FoBxYL0mr2obcI353jJ7q-_3l19a25_3Hy_-nLb-Naq0mgj9DSGoUccJNpxCBKCCGawZkJVQ99isKgFggz1izCBAd230NkBxl7pS_bhtHef098DUnFLJI_zDCumA7lBKmuNkhVUJ9DnRJQxuH2OC-TNSeGOXt2jV3f06kTnjl7r0Lvz9sO44PQ0chZZgfdnAMjDHKowH-mJ65Tu9KAr9_nEYXXxEDE78hFXj1PM6IubUvzfHf8AMYKYXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71299821</pqid></control><display><type>article</type><title>Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Taraschi, Theodore F. ; O’Donnell, Megan ; Martinez, Sandra ; Schneider, Timothy ; Trelka, Darin ; Fowler, Velia M. ; Tilley, Leann ; Moriyama, Yoshinori</creator><creatorcontrib>Taraschi, Theodore F. ; O’Donnell, Megan ; Martinez, Sandra ; Schneider, Timothy ; Trelka, Darin ; Fowler, Velia M. ; Tilley, Leann ; Moriyama, Yoshinori</creatorcontrib><description>The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite-encoded proteins to the erythrocyte plasma membrane. Activation of G proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium homologues of COPII and N-ethylmaleimide-sensitive factor, proteins involved in intracellular transport between the Golgi apparatus and the endoplasmic reticulum. These vesicles contain malarial proteins that appear on the erythrocyte plasma membrane, as well as actin and myosin. It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2003-05-1448</identifier><identifier>PMID: 12869498</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Actins - metabolism ; Animals ; Biological and medical sciences ; Carrier Proteins ; COP-Coated Vesicles ; Cytoplasmic Vesicles - metabolism ; Cytoplasmic Vesicles - virology ; Erythrocyte Membrane ; Erythrocytes - parasitology ; Erythrocytes - ultrastructure ; Host-Parasite Interactions ; Human protozoal diseases ; Humans ; Infectious diseases ; Malaria ; Medical sciences ; Molecular Mimicry ; Myosins - metabolism ; N-Ethylmaleimide-Sensitive Proteins ; Parasitic diseases ; Plasmodium falciparum - chemistry ; Plasmodium falciparum - physiology ; Protein Transport ; Protozoal diseases ; Protozoan Proteins - metabolism ; Vesicular Transport Proteins</subject><ispartof>Blood, 2003-11, Vol.102 (9), p.3420-3426</ispartof><rights>2003 American Society of Hematology</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-3803dbf76ee71e9b7f1af0f8798de287964ef9e30ea1f432fda8a364a597ab623</citedby><cites>FETCH-LOGICAL-c492t-3803dbf76ee71e9b7f1af0f8798de287964ef9e30ea1f432fda8a364a597ab623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15235373$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12869498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taraschi, Theodore F.</creatorcontrib><creatorcontrib>O’Donnell, Megan</creatorcontrib><creatorcontrib>Martinez, Sandra</creatorcontrib><creatorcontrib>Schneider, Timothy</creatorcontrib><creatorcontrib>Trelka, Darin</creatorcontrib><creatorcontrib>Fowler, Velia M.</creatorcontrib><creatorcontrib>Tilley, Leann</creatorcontrib><creatorcontrib>Moriyama, Yoshinori</creatorcontrib><title>Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites</title><title>Blood</title><addtitle>Blood</addtitle><description>The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite-encoded proteins to the erythrocyte plasma membrane. Activation of G proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium homologues of COPII and N-ethylmaleimide-sensitive factor, proteins involved in intracellular transport between the Golgi apparatus and the endoplasmic reticulum. These vesicles contain malarial proteins that appear on the erythrocyte plasma membrane, as well as actin and myosin. It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane.</description><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>COP-Coated Vesicles</subject><subject>Cytoplasmic Vesicles - metabolism</subject><subject>Cytoplasmic Vesicles - virology</subject><subject>Erythrocyte Membrane</subject><subject>Erythrocytes - parasitology</subject><subject>Erythrocytes - ultrastructure</subject><subject>Host-Parasite Interactions</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Medical sciences</subject><subject>Molecular Mimicry</subject><subject>Myosins - metabolism</subject><subject>N-Ethylmaleimide-Sensitive Proteins</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum - chemistry</subject><subject>Plasmodium falciparum - physiology</subject><subject>Protein Transport</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins - metabolism</subject><subject>Vesicular Transport Proteins</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtvFDEMgCMEokvhD3BAucBtII95JBIXVNGCVAkO7Tl4Mo4ImpkscbbS_Huy3ZV642Rb_mzZH2NvpfgopVGfxjmlqVFC6EZ0jWxb84ztZKdMI4QSz9lOCNE3rR3kBXtF9EcI2WrVvWQXUpnettbs2K8bXDFDiWnlKXBYOeat_M7JbwX5A1L0M_KSYaV9yoXTRgUXPm785wy0pCkeFh5g9nEPuaYLzJAj8FoBxYL0mr2obcI353jJ7q-_3l19a25_3Hy_-nLb-Naq0mgj9DSGoUccJNpxCBKCCGawZkJVQ99isKgFggz1izCBAd230NkBxl7pS_bhtHef098DUnFLJI_zDCumA7lBKmuNkhVUJ9DnRJQxuH2OC-TNSeGOXt2jV3f06kTnjl7r0Lvz9sO44PQ0chZZgfdnAMjDHKowH-mJ65Tu9KAr9_nEYXXxEDE78hFXj1PM6IubUvzfHf8AMYKYXA</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Taraschi, Theodore F.</creator><creator>O’Donnell, Megan</creator><creator>Martinez, Sandra</creator><creator>Schneider, Timothy</creator><creator>Trelka, Darin</creator><creator>Fowler, Velia M.</creator><creator>Tilley, Leann</creator><creator>Moriyama, Yoshinori</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites</title><author>Taraschi, Theodore F. ; O’Donnell, Megan ; Martinez, Sandra ; Schneider, Timothy ; Trelka, Darin ; Fowler, Velia M. ; Tilley, Leann ; Moriyama, Yoshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-3803dbf76ee71e9b7f1af0f8798de287964ef9e30ea1f432fda8a364a597ab623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Actins - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins</topic><topic>COP-Coated Vesicles</topic><topic>Cytoplasmic Vesicles - metabolism</topic><topic>Cytoplasmic Vesicles - virology</topic><topic>Erythrocyte Membrane</topic><topic>Erythrocytes - parasitology</topic><topic>Erythrocytes - ultrastructure</topic><topic>Host-Parasite Interactions</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Medical sciences</topic><topic>Molecular Mimicry</topic><topic>Myosins - metabolism</topic><topic>N-Ethylmaleimide-Sensitive Proteins</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum - chemistry</topic><topic>Plasmodium falciparum - physiology</topic><topic>Protein Transport</topic><topic>Protozoal diseases</topic><topic>Protozoan Proteins - metabolism</topic><topic>Vesicular Transport Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taraschi, Theodore F.</creatorcontrib><creatorcontrib>O’Donnell, Megan</creatorcontrib><creatorcontrib>Martinez, Sandra</creatorcontrib><creatorcontrib>Schneider, Timothy</creatorcontrib><creatorcontrib>Trelka, Darin</creatorcontrib><creatorcontrib>Fowler, Velia M.</creatorcontrib><creatorcontrib>Tilley, Leann</creatorcontrib><creatorcontrib>Moriyama, Yoshinori</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taraschi, Theodore F.</au><au>O’Donnell, Megan</au><au>Martinez, Sandra</au><au>Schneider, Timothy</au><au>Trelka, Darin</au><au>Fowler, Velia M.</au><au>Tilley, Leann</au><au>Moriyama, Yoshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>102</volume><issue>9</issue><spage>3420</spage><epage>3426</epage><pages>3420-3426</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite-encoded proteins to the erythrocyte plasma membrane. Activation of G proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium homologues of COPII and N-ethylmaleimide-sensitive factor, proteins involved in intracellular transport between the Golgi apparatus and the endoplasmic reticulum. These vesicles contain malarial proteins that appear on the erythrocyte plasma membrane, as well as actin and myosin. It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>12869498</pmid><doi>10.1182/blood-2003-05-1448</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 2003-11, Vol.102 (9), p.3420-3426 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71299821 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Actins - metabolism Animals Biological and medical sciences Carrier Proteins COP-Coated Vesicles Cytoplasmic Vesicles - metabolism Cytoplasmic Vesicles - virology Erythrocyte Membrane Erythrocytes - parasitology Erythrocytes - ultrastructure Host-Parasite Interactions Human protozoal diseases Humans Infectious diseases Malaria Medical sciences Molecular Mimicry Myosins - metabolism N-Ethylmaleimide-Sensitive Proteins Parasitic diseases Plasmodium falciparum - chemistry Plasmodium falciparum - physiology Protein Transport Protozoal diseases Protozoan Proteins - metabolism Vesicular Transport Proteins |
| title | Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T00%3A03%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Generation%20of%20an%20erythrocyte%20vesicle%20transport%20system%20by%20Plasmodium%20falciparum%20malaria%20parasites&rft.jtitle=Blood&rft.au=Taraschi,%20Theodore%20F.&rft.date=2003-11-01&rft.volume=102&rft.issue=9&rft.spage=3420&rft.epage=3426&rft.pages=3420-3426&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood-2003-05-1448&rft_dat=%3Cproquest_cross%3E71299821%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71299821&rft_id=info:pmid/12869498&rft_els_id=S0006497120539475&rfr_iscdi=true |