Pharmacological Characterization of a Serotonin Receptor (5-HT7) Stimulating cAMP Production in Human Corneal Epithelial Cells

To study the mRNA and pharmacology of a serotonin (5-HT) receptor positively coupled to adenylyl cyclase in normal, primary (P-CEPI), and immortalized human corneal epithelial cells (CEPI-17-CL4), by using numerous 5-HT agonists and antagonists. To determine and compare cloned human 5-HT7 receptor b...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2003-11, Vol.44 (11), p.4837-4844
Hauptverfasser:	Crider, Julie Y, Williams, Gary W, Drace, Colene D, Katoli, Parvaneh, Senchyna, Michelle, Sharif, Najam A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Adult Biological and medical sciences Cell Line Cell Membrane - metabolism Cyclic AMP - biosynthesis Epithelium, Corneal - drug effects Epithelium, Corneal - metabolism Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans Kidney - embryology Lysergic Acid Diethylamide - metabolism Middle Aged Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Vertebrates: nervous system and sense organs
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