An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene
Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may...
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Veröffentlicht in: | Biotechnology letters 2003-09, Vol.25 (18), p.1549-1553 |
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container_title | Biotechnology letters |
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creator | Chung, Hye Kyung Bae, Eun Kyong Ji, Hee Jung Hwang, Jung Suk Park, Dong Woon Kim, Jung Eun Jung, Hwa Jin Choi, Hyun Ju Lee, Dong Seok Youn, Hyun Joo |
description | Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression. |
doi_str_mv | 10.1023/A:1025482516404 |
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An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression.</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1023/A:1025482516404</identifier><identifier>PMID: 14571981</identifier><identifier>CODEN: BILED3</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Animals ; Apoptosis ; Apoptosis - drug effects ; Artemisia - chemistry ; Biological and medical sciences ; Biotechnology ; Cell Survival - drug effects ; Cells, Cultured ; Cellular biology ; Dose-Response Relationship, Drug ; Down-Regulation - drug effects ; fas Receptor - genetics ; fas Receptor - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Herbs ; Mice ; Mice, Inbred BALB C ; Mortality ; Oligosaccharides - isolation & purification ; Oligosaccharides - pharmacology ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Thymus Gland - drug effects ; Thymus Gland - metabolism</subject><ispartof>Biotechnology letters, 2003-09, Vol.25 (18), p.1549-1553</ispartof><rights>2004 INIST-CNRS</rights><rights>Kluwer Academic Publishers 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-9a6136fb22387ac7a991e69bb3f5081e955404a9d71bfe6d17531073bd566bb73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15135602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14571981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Hye Kyung</creatorcontrib><creatorcontrib>Bae, Eun Kyong</creatorcontrib><creatorcontrib>Ji, Hee Jung</creatorcontrib><creatorcontrib>Hwang, Jung Suk</creatorcontrib><creatorcontrib>Park, Dong Woon</creatorcontrib><creatorcontrib>Kim, Jung Eun</creatorcontrib><creatorcontrib>Jung, Hwa Jin</creatorcontrib><creatorcontrib>Choi, Hyun Ju</creatorcontrib><creatorcontrib>Lee, Dong Seok</creatorcontrib><creatorcontrib>Youn, Hyun Joo</creatorcontrib><title>An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene</title><title>Biotechnology letters</title><addtitle>Biotechnol Lett</addtitle><description>Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Artemisia - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Cellular biology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Down-Regulation - drug effects</subject><subject>fas Receptor - genetics</subject><subject>fas Receptor - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Herbs</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mortality</subject><subject>Oligosaccharides - isolation & purification</subject><subject>Oligosaccharides - pharmacology</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Thymus Gland - drug effects</subject><subject>Thymus Gland - metabolism</subject><issn>0141-5492</issn><issn>1573-6776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU9r3DAQxUVoaTZpz7kFUWhubiTLkqzclpC0pYFekrOR5LHXwZYc_SHsJ-nXjWg2BHp6A_ObYeY9hM4o-U5JzS63V0V409acioY0R2hDuWSVkFJ8QBtCG1rxRtXH6CTGR0KIkkR-Qse04ZKqlm7Q363Dfp5GH7W1Ox2mHvAQtE2Td6XwC_7tA2iHlzw--5DwDoLBMa9rgBgh4h502mE_4LQDvPgcoVT7xdt9Kt3JYZvnlANgs8e9f3ZVgDHPOk1u_Ddyq992BLCwJh_wCA4-o4-DniN8Oegperi9ub_-Wd39-fHrentXWdaoVCktKBODqWvWSm2lVoqCUMawgZOWguK82KJVL6kZQPRUckaJZKbnQhgj2Sm6eN27Bv-UIaZumaKFedYOyjOdpLUSnLUF_Pof-OhzcOW2TrISgBJCFOj8AGWzQN-tYVp02Hdvfhfg2wHQ0eq5OO3sFN85ThkXJdgXjaiQ0w</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Chung, Hye Kyung</creator><creator>Bae, Eun Kyong</creator><creator>Ji, Hee Jung</creator><creator>Hwang, Jung Suk</creator><creator>Park, Dong Woon</creator><creator>Kim, Jung Eun</creator><creator>Jung, Hwa Jin</creator><creator>Choi, Hyun Ju</creator><creator>Lee, Dong Seok</creator><creator>Youn, Hyun Joo</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene</title><author>Chung, Hye Kyung ; Bae, Eun Kyong ; Ji, Hee Jung ; Hwang, Jung Suk ; Park, Dong Woon ; Kim, Jung Eun ; Jung, Hwa Jin ; Choi, Hyun Ju ; Lee, Dong Seok ; Youn, Hyun Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-9a6136fb22387ac7a991e69bb3f5081e955404a9d71bfe6d17531073bd566bb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Artemisia - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Cellular biology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Down-Regulation - drug effects</topic><topic>fas Receptor - genetics</topic><topic>fas Receptor - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Herbs</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mortality</topic><topic>Oligosaccharides - isolation & purification</topic><topic>Oligosaccharides - pharmacology</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Thymus Gland - drug effects</topic><topic>Thymus Gland - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Hye Kyung</creatorcontrib><creatorcontrib>Bae, Eun Kyong</creatorcontrib><creatorcontrib>Ji, Hee Jung</creatorcontrib><creatorcontrib>Hwang, Jung Suk</creatorcontrib><creatorcontrib>Park, Dong Woon</creatorcontrib><creatorcontrib>Kim, Jung Eun</creatorcontrib><creatorcontrib>Jung, Hwa Jin</creatorcontrib><creatorcontrib>Choi, Hyun Ju</creatorcontrib><creatorcontrib>Lee, Dong Seok</creatorcontrib><creatorcontrib>Youn, Hyun Joo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Hye Kyung</au><au>Bae, Eun Kyong</au><au>Ji, Hee Jung</au><au>Hwang, Jung Suk</au><au>Park, Dong Woon</au><au>Kim, Jung Eun</au><au>Jung, Hwa Jin</au><au>Choi, Hyun Ju</au><au>Lee, Dong Seok</au><au>Youn, Hyun Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene</atitle><jtitle>Biotechnology letters</jtitle><addtitle>Biotechnol Lett</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>25</volume><issue>18</issue><spage>1549</spage><epage>1553</epage><pages>1549-1553</pages><issn>0141-5492</issn><eissn>1573-6776</eissn><coden>BILED3</coden><abstract>Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>14571981</pmid><doi>10.1023/A:1025482516404</doi><tpages>5</tpages></addata></record> |
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subjects | Animals Apoptosis Apoptosis - drug effects Artemisia - chemistry Biological and medical sciences Biotechnology Cell Survival - drug effects Cells, Cultured Cellular biology Dose-Response Relationship, Drug Down-Regulation - drug effects fas Receptor - genetics fas Receptor - metabolism Fundamental and applied biological sciences. Psychology Gene expression Herbs Mice Mice, Inbred BALB C Mortality Oligosaccharides - isolation & purification Oligosaccharides - pharmacology Plant Extracts - isolation & purification Plant Extracts - pharmacology Thymus Gland - drug effects Thymus Gland - metabolism |
title | An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene |
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