An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene

Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may...

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Veröffentlicht in:Biotechnology letters 2003-09, Vol.25 (18), p.1549-1553
Hauptverfasser: Chung, Hye Kyung, Bae, Eun Kyong, Ji, Hee Jung, Hwang, Jung Suk, Park, Dong Woon, Kim, Jung Eun, Jung, Hwa Jin, Choi, Hyun Ju, Lee, Dong Seok, Youn, Hyun Joo
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container_end_page 1553
container_issue 18
container_start_page 1549
container_title Biotechnology letters
container_volume 25
creator Chung, Hye Kyung
Bae, Eun Kyong
Ji, Hee Jung
Hwang, Jung Suk
Park, Dong Woon
Kim, Jung Eun
Jung, Hwa Jin
Choi, Hyun Ju
Lee, Dong Seok
Youn, Hyun Joo
description Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression.
doi_str_mv 10.1023/A:1025482516404
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An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. 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subjects Animals
Apoptosis
Apoptosis - drug effects
Artemisia - chemistry
Biological and medical sciences
Biotechnology
Cell Survival - drug effects
Cells, Cultured
Cellular biology
Dose-Response Relationship, Drug
Down-Regulation - drug effects
fas Receptor - genetics
fas Receptor - metabolism
Fundamental and applied biological sciences. Psychology
Gene expression
Herbs
Mice
Mice, Inbred BALB C
Mortality
Oligosaccharides - isolation & purification
Oligosaccharides - pharmacology
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Thymus Gland - drug effects
Thymus Gland - metabolism
title An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene
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