Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
Asthma is a complex genetic disease characterized by reversible intermittent airway obstruction and respiratory symptoms primarily caused by acute and chronic bronchial inflammation. Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implic...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2003-10, Vol.112 (4), p.717-722 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Howard, Timothy D Postma, Dirkje S Jongepier, Hajo Moore, Wendy C Koppelman, Gerard H Zheng, Siqun L Xu, Jianfeng Bleecker, Eugene R Meyers, Deborah A |
| description | Asthma is a complex genetic disease characterized by reversible intermittent airway obstruction and respiratory symptoms primarily caused by acute and chronic bronchial inflammation. Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33
(ADAM33), was implicated in asthma susceptibility.
We sought to determine whether polymorphisms in
ADAM33 are associated with asthma or closely related phenotypes in 4 different asthma populations.
Eight single nucleotide polymorphisms (SNPs) were evaluated in the 3′ portion of
ADAM33 in 4 unique asthma populations (African American, US white, US Hispanic, and Dutch white). These SNPs were previously reported to be associated with asthma in white populations from the United States and United Kingdom.
Significant associations were observed with at least one SNP and asthma in each population (
P = .0009–.04). Related phenotypes that included total serum IgE levels and skin test responsiveness were also associated (
P = .003–.05). However, no single SNP was associated across all populations. Additionally, haplotype analysis revealed that no single haplotype accounted for asthma susceptibility risk, although potential risk haplotypes existed within some of the populations.
Replication of the original
ADAM33 findings in these 4 additional asthma populations suggests that this gene (and perhaps others that interact with it) is important in the development and pathogenesis of asthma. |
| doi_str_mv | 10.1016/S0091-6749(03)01939-0 |
| format | Article |
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(ADAM33), was implicated in asthma susceptibility.
We sought to determine whether polymorphisms in
ADAM33 are associated with asthma or closely related phenotypes in 4 different asthma populations.
Eight single nucleotide polymorphisms (SNPs) were evaluated in the 3′ portion of
ADAM33 in 4 unique asthma populations (African American, US white, US Hispanic, and Dutch white). These SNPs were previously reported to be associated with asthma in white populations from the United States and United Kingdom.
Significant associations were observed with at least one SNP and asthma in each population (
P = .0009–.04). Related phenotypes that included total serum IgE levels and skin test responsiveness were also associated (
P = .003–.05). However, no single SNP was associated across all populations. Additionally, haplotype analysis revealed that no single haplotype accounted for asthma susceptibility risk, although potential risk haplotypes existed within some of the populations.
Replication of the original
ADAM33 findings in these 4 additional asthma populations suggests that this gene (and perhaps others that interact with it) is important in the development and pathogenesis of asthma.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/S0091-6749(03)01939-0</identifier><identifier>PMID: 14564349</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>ADAM Proteins ; ADAM33 ; African Americans ; African Continental Ancestry Group - genetics ; Airway management ; Allergic diseases ; association ; Asthma ; Asthma - blood ; Asthma - diagnosis ; Asthma - genetics ; Biological and medical sciences ; Case-Control Studies ; European Continental Ancestry Group - genetics ; Families & family life ; Gene Frequency ; Genes ; Genetic Predisposition to Disease - genetics ; Genetics ; haplotype ; Haplotypes ; Hispanic Americans ; Hispanic people ; Humans ; Hypotheses ; Immunoglobulin E - blood ; Immunopathology ; Medical sciences ; Metalloendopeptidases - genetics ; Netherlands - ethnology ; Phenotype ; Polymorphism, Single Nucleotide ; Population ; Proteins ; Respiratory and ent allergic diseases ; Signal transduction ; Skin Tests ; Studies</subject><ispartof>Journal of allergy and clinical immunology, 2003-10, Vol.112 (4), p.717-722</ispartof><rights>2003 Mosby, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-2eb64c5f66665523ff9c265b027de98bc6e82c583807d383a32415a6d60df07e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674903019390$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15205982$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14564349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howard, Timothy D</creatorcontrib><creatorcontrib>Postma, Dirkje S</creatorcontrib><creatorcontrib>Jongepier, Hajo</creatorcontrib><creatorcontrib>Moore, Wendy C</creatorcontrib><creatorcontrib>Koppelman, Gerard H</creatorcontrib><creatorcontrib>Zheng, Siqun L</creatorcontrib><creatorcontrib>Xu, Jianfeng</creatorcontrib><creatorcontrib>Bleecker, Eugene R</creatorcontrib><creatorcontrib>Meyers, Deborah A</creatorcontrib><title>Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Asthma is a complex genetic disease characterized by reversible intermittent airway obstruction and respiratory symptoms primarily caused by acute and chronic bronchial inflammation. Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33
(ADAM33), was implicated in asthma susceptibility.
We sought to determine whether polymorphisms in
ADAM33 are associated with asthma or closely related phenotypes in 4 different asthma populations.
Eight single nucleotide polymorphisms (SNPs) were evaluated in the 3′ portion of
ADAM33 in 4 unique asthma populations (African American, US white, US Hispanic, and Dutch white). These SNPs were previously reported to be associated with asthma in white populations from the United States and United Kingdom.
Significant associations were observed with at least one SNP and asthma in each population (
P = .0009–.04). Related phenotypes that included total serum IgE levels and skin test responsiveness were also associated (
P = .003–.05). However, no single SNP was associated across all populations. Additionally, haplotype analysis revealed that no single haplotype accounted for asthma susceptibility risk, although potential risk haplotypes existed within some of the populations.
Replication of the original
ADAM33 findings in these 4 additional asthma populations suggests that this gene (and perhaps others that interact with it) is important in the development and pathogenesis of asthma.</description><subject>ADAM Proteins</subject><subject>ADAM33</subject><subject>African Americans</subject><subject>African Continental Ancestry Group - genetics</subject><subject>Airway management</subject><subject>Allergic diseases</subject><subject>association</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - diagnosis</subject><subject>Asthma - genetics</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Families & family life</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetics</subject><subject>haplotype</subject><subject>Haplotypes</subject><subject>Hispanic Americans</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Metalloendopeptidases - genetics</subject><subject>Netherlands - ethnology</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Proteins</subject><subject>Respiratory and ent allergic diseases</subject><subject>Signal transduction</subject><subject>Skin Tests</subject><subject>Studies</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhgdR7Fr9CUpAlPZi9CSZZJIrWeonVLxQr0M2c6abMptsk0yl_97sBxa8aW4Oged9z8fbNC8pvKNA5fufAJq2su_0GfBzoJrrFh41Cwq6b6Vi4nGz-IecNM9yvob650o_bU5oJ2THO71o4jLn6LwtPgYSR2LJ4LMPBa-SD8SGgWyw2GmK2xQL2oyEc3K2_Lj8zvk5ucKA5I8va2JzWW8sqRos6-BdldxVq1tMVbKN23nat8jPmyejnTK-ONbT5vfnT78uvraXP758u1hetq7TfWkZrmTnxCjrE4LxcdSOSbEC1g-o1cpJVMwJxRX0A1fcctZRYeUgYRihR37avD341rlvZszFbHx2OE02YJyz6SnTQjL9IEiVFr0AqODr_8DrOKdQlzBUQKd4B1pUShwol2LOCUezTX5j052hYHbBmX1wZpeKAW72wZmd-6uj-7za4HCvOiZVgTdHwOZ63THZ4Hy-5wQDoRWr3IcDh_W6tx6Tyc5jcDj4hK6YIfoHRvkLLHizQw</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Howard, Timothy D</creator><creator>Postma, Dirkje S</creator><creator>Jongepier, Hajo</creator><creator>Moore, Wendy C</creator><creator>Koppelman, Gerard H</creator><creator>Zheng, Siqun L</creator><creator>Xu, Jianfeng</creator><creator>Bleecker, Eugene R</creator><creator>Meyers, Deborah A</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations</title><author>Howard, Timothy D ; Postma, Dirkje S ; Jongepier, Hajo ; Moore, Wendy C ; Koppelman, Gerard H ; Zheng, Siqun L ; Xu, Jianfeng ; Bleecker, Eugene R ; Meyers, Deborah A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-2eb64c5f66665523ff9c265b027de98bc6e82c583807d383a32415a6d60df07e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>ADAM Proteins</topic><topic>ADAM33</topic><topic>African Americans</topic><topic>African Continental Ancestry Group - genetics</topic><topic>Airway management</topic><topic>Allergic diseases</topic><topic>association</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - diagnosis</topic><topic>Asthma - genetics</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Families & family life</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetics</topic><topic>haplotype</topic><topic>Haplotypes</topic><topic>Hispanic Americans</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Immunoglobulin E - blood</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Metalloendopeptidases - genetics</topic><topic>Netherlands - ethnology</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Proteins</topic><topic>Respiratory and ent allergic diseases</topic><topic>Signal transduction</topic><topic>Skin Tests</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howard, Timothy D</creatorcontrib><creatorcontrib>Postma, Dirkje S</creatorcontrib><creatorcontrib>Jongepier, Hajo</creatorcontrib><creatorcontrib>Moore, Wendy C</creatorcontrib><creatorcontrib>Koppelman, Gerard H</creatorcontrib><creatorcontrib>Zheng, Siqun L</creatorcontrib><creatorcontrib>Xu, Jianfeng</creatorcontrib><creatorcontrib>Bleecker, Eugene R</creatorcontrib><creatorcontrib>Meyers, Deborah A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howard, Timothy D</au><au>Postma, Dirkje S</au><au>Jongepier, Hajo</au><au>Moore, Wendy C</au><au>Koppelman, Gerard H</au><au>Zheng, Siqun L</au><au>Xu, Jianfeng</au><au>Bleecker, Eugene R</au><au>Meyers, Deborah A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>112</volume><issue>4</issue><spage>717</spage><epage>722</epage><pages>717-722</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Asthma is a complex genetic disease characterized by reversible intermittent airway obstruction and respiratory symptoms primarily caused by acute and chronic bronchial inflammation. Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33
(ADAM33), was implicated in asthma susceptibility.
We sought to determine whether polymorphisms in
ADAM33 are associated with asthma or closely related phenotypes in 4 different asthma populations.
Eight single nucleotide polymorphisms (SNPs) were evaluated in the 3′ portion of
ADAM33 in 4 unique asthma populations (African American, US white, US Hispanic, and Dutch white). These SNPs were previously reported to be associated with asthma in white populations from the United States and United Kingdom.
Significant associations were observed with at least one SNP and asthma in each population (
P = .0009–.04). Related phenotypes that included total serum IgE levels and skin test responsiveness were also associated (
P = .003–.05). However, no single SNP was associated across all populations. Additionally, haplotype analysis revealed that no single haplotype accounted for asthma susceptibility risk, although potential risk haplotypes existed within some of the populations.
Replication of the original
ADAM33 findings in these 4 additional asthma populations suggests that this gene (and perhaps others that interact with it) is important in the development and pathogenesis of asthma.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>14564349</pmid><doi>10.1016/S0091-6749(03)01939-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | ADAM Proteins ADAM33 African Americans African Continental Ancestry Group - genetics Airway management Allergic diseases association Asthma Asthma - blood Asthma - diagnosis Asthma - genetics Biological and medical sciences Case-Control Studies European Continental Ancestry Group - genetics Families & family life Gene Frequency Genes Genetic Predisposition to Disease - genetics Genetics haplotype Haplotypes Hispanic Americans Hispanic people Humans Hypotheses Immunoglobulin E - blood Immunopathology Medical sciences Metalloendopeptidases - genetics Netherlands - ethnology Phenotype Polymorphism, Single Nucleotide Population Proteins Respiratory and ent allergic diseases Signal transduction Skin Tests Studies |
| title | Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations |
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