EWS/FLI function varies in different cellular backgrounds

EWS/FLI and other EWS/ets chimeric transcription factors play a central role in the biology of the Ewing family tumors. As with many oncogenes, EWS/FLI biologic activity can be demonstrated in a limited range of cellular contexts. To investigate the causes of this restriction, we demonstrate that tw...

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Veröffentlicht in:	Experimental cell research 2003-11, Vol.290 (2), p.414-419
Hauptverfasser:	Zwerner, Jeffrey P, Guimbellot, Jennifer, May, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern Blotting, Western Cell Transformation, Neoplastic Ewing family tumors Ewing's sarcoma EWS/FLI Fibroblasts - metabolism Gene Expression Regulation, Neoplastic Humans Lymphokines Mice Mice, SCID Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology NIH3T3 Oncogene Proteins, Fusion - physiology PDGF-C Phenotype Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism Proto-Oncogene Protein c-fli-1 RNA-Binding Protein EWS Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Transcription Factors - physiology Up-Regulation
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