Endothelin-1 levels in interstitial lung disease patients during sleep
Hypoxemia stimulates endothelin-1 (ET-1) secretion. The reduction in alveolar ventilation during sleep is considered sufficient to account for the hypoxemia observed in patients with respiratory diseases. The aim of this study was to evaluate the arterial ET-1 levels and their relationship with pulm...
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| Veröffentlicht in: | Sleep & breathing 2003-09, Vol.7 (3), p.111-118 |
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| creator | TRAKADA, Georgia NIKOLAOU, Eugenia POULI, Athanasia TSIAMITA, Maria SPIROPOULOS, Kostas |
| description | Hypoxemia stimulates endothelin-1 (ET-1) secretion. The reduction in alveolar ventilation during sleep is considered sufficient to account for the hypoxemia observed in patients with respiratory diseases.
The aim of this study was to evaluate the arterial ET-1 levels and their relationship with pulmonary hypertension in patients with interstitial lung disease (ILD) during sleep.
We examined 38 patients with ILD using formal polysomnography (electroencephalogram, electrocardiogram, airflow, respiratory muscle movement, oximeter) to detect the presence of nocturnal, nonapneic, oxyhemoglobin desaturation. All patients desaturated below a baseline sleep saturation of 90% for 5 minutes or more, reaching a nadir saturation of at least 85%. Each patient had already undergone right heart catheterization with a Swan-Ganz catheter for measuring hemodynamic parameters. Sampling of arterial blood from a radial artery line for determination of blood gases and ET-1 values was performed simultaneously, after 5 minutes of the first desaturation.
At rest, arterial ET-1 levels were higher in ILD patients (1.73 +/- 0.37 mgr/mL) than in controls (1.22 +/- 0.15 mgr/mL) ( p < 0.001). Also, the patients with pulmonary hypertension (Pa > 20 mm Hg) presented significantly higher arterial ET-1 levels (1.86 +/- 0.32 mgr/mL) than those without pulmonary hypertension (1.31 +/- 0.13 mgr/mL) ( p < 0.001). Arterial ET-1 levels were significantly correlated with mean pulmonary arterial pressure (PAP) (r = 0.749, p < 0.001), and arterial oxygen partial pressure (PaO2) (r = 0.79, p < 0.001). At sleep, during desaturation, arterial ET-1 levels significantly increased in all patients (2.46 +/- 0.13 mgr/mL) as compared with resting values ( p < 0.001). Arterial ET-1 levels were significantly correlated with PAP (r = 0.657, p < 0.001) and PaO2 (r = 0.93, p < 0.001).
According to our study, arterial ET-1 is markedly increased in ILD patients, especially in those with pulmonary hypertension. |
| doi_str_mv | 10.1007/s11325-003-0111-y |
| format | Article |
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The aim of this study was to evaluate the arterial ET-1 levels and their relationship with pulmonary hypertension in patients with interstitial lung disease (ILD) during sleep.
We examined 38 patients with ILD using formal polysomnography (electroencephalogram, electrocardiogram, airflow, respiratory muscle movement, oximeter) to detect the presence of nocturnal, nonapneic, oxyhemoglobin desaturation. All patients desaturated below a baseline sleep saturation of 90% for 5 minutes or more, reaching a nadir saturation of at least 85%. Each patient had already undergone right heart catheterization with a Swan-Ganz catheter for measuring hemodynamic parameters. Sampling of arterial blood from a radial artery line for determination of blood gases and ET-1 values was performed simultaneously, after 5 minutes of the first desaturation.
At rest, arterial ET-1 levels were higher in ILD patients (1.73 +/- 0.37 mgr/mL) than in controls (1.22 +/- 0.15 mgr/mL) ( p < 0.001). Also, the patients with pulmonary hypertension (Pa > 20 mm Hg) presented significantly higher arterial ET-1 levels (1.86 +/- 0.32 mgr/mL) than those without pulmonary hypertension (1.31 +/- 0.13 mgr/mL) ( p < 0.001). Arterial ET-1 levels were significantly correlated with mean pulmonary arterial pressure (PAP) (r = 0.749, p < 0.001), and arterial oxygen partial pressure (PaO2) (r = 0.79, p < 0.001). At sleep, during desaturation, arterial ET-1 levels significantly increased in all patients (2.46 +/- 0.13 mgr/mL) as compared with resting values ( p < 0.001). Arterial ET-1 levels were significantly correlated with PAP (r = 0.657, p < 0.001) and PaO2 (r = 0.93, p < 0.001).
According to our study, arterial ET-1 is markedly increased in ILD patients, especially in those with pulmonary hypertension.]]></description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-003-0111-y</identifier><identifier>PMID: 14569522</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Electrocardiography ; Electroencephalography ; Endothelin-1 - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Hemodynamics - physiology ; Humans ; Hypertension ; Hypertension, Pulmonary - complications ; Hypoxia - diagnosis ; Hypoxia - etiology ; Lung diseases ; Lung Diseases, Interstitial - complications ; Lung Diseases, Interstitial - diagnosis ; Lung Diseases, Interstitial - metabolism ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Oximetry ; Polysomnography - instrumentation ; Respiratory diseases ; Sleep - physiology ; Sleep. Vigilance ; Vertebrates: nervous system and sense organs</subject><ispartof>Sleep & breathing, 2003-09, Vol.7 (3), p.111-118</ispartof><rights>2004 INIST-CNRS</rights><rights>Thieme Medical Publishers, Inc. 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c269t-a3f2d34f93bec6c114e927cc050d66c0b982970152a728e9d9a9850395aaf70e3</citedby><cites>FETCH-LOGICAL-c269t-a3f2d34f93bec6c114e927cc050d66c0b982970152a728e9d9a9850395aaf70e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15462790$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14569522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TRAKADA, Georgia</creatorcontrib><creatorcontrib>NIKOLAOU, Eugenia</creatorcontrib><creatorcontrib>POULI, Athanasia</creatorcontrib><creatorcontrib>TSIAMITA, Maria</creatorcontrib><creatorcontrib>SPIROPOULOS, Kostas</creatorcontrib><title>Endothelin-1 levels in interstitial lung disease patients during sleep</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><description><![CDATA[Hypoxemia stimulates endothelin-1 (ET-1) secretion. The reduction in alveolar ventilation during sleep is considered sufficient to account for the hypoxemia observed in patients with respiratory diseases.
The aim of this study was to evaluate the arterial ET-1 levels and their relationship with pulmonary hypertension in patients with interstitial lung disease (ILD) during sleep.
We examined 38 patients with ILD using formal polysomnography (electroencephalogram, electrocardiogram, airflow, respiratory muscle movement, oximeter) to detect the presence of nocturnal, nonapneic, oxyhemoglobin desaturation. All patients desaturated below a baseline sleep saturation of 90% for 5 minutes or more, reaching a nadir saturation of at least 85%. Each patient had already undergone right heart catheterization with a Swan-Ganz catheter for measuring hemodynamic parameters. Sampling of arterial blood from a radial artery line for determination of blood gases and ET-1 values was performed simultaneously, after 5 minutes of the first desaturation.
At rest, arterial ET-1 levels were higher in ILD patients (1.73 +/- 0.37 mgr/mL) than in controls (1.22 +/- 0.15 mgr/mL) ( p < 0.001). Also, the patients with pulmonary hypertension (Pa > 20 mm Hg) presented significantly higher arterial ET-1 levels (1.86 +/- 0.32 mgr/mL) than those without pulmonary hypertension (1.31 +/- 0.13 mgr/mL) ( p < 0.001). Arterial ET-1 levels were significantly correlated with mean pulmonary arterial pressure (PAP) (r = 0.749, p < 0.001), and arterial oxygen partial pressure (PaO2) (r = 0.79, p < 0.001). At sleep, during desaturation, arterial ET-1 levels significantly increased in all patients (2.46 +/- 0.13 mgr/mL) as compared with resting values ( p < 0.001). Arterial ET-1 levels were significantly correlated with PAP (r = 0.657, p < 0.001) and PaO2 (r = 0.93, p < 0.001).
According to our study, arterial ET-1 is markedly increased in ILD patients, especially in those with pulmonary hypertension.]]></description><subject>Biological and medical sciences</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Electrocardiography</subject><subject>Electroencephalography</subject><subject>Endothelin-1 - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Hypoxia - diagnosis</subject><subject>Hypoxia - etiology</subject><subject>Lung diseases</subject><subject>Lung Diseases, Interstitial - complications</subject><subject>Lung Diseases, Interstitial - diagnosis</subject><subject>Lung Diseases, Interstitial - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Oximetry</subject><subject>Polysomnography - instrumentation</subject><subject>Respiratory diseases</subject><subject>Sleep - physiology</subject><subject>Sleep. 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Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Electrocardiography</topic><topic>Electroencephalography</topic><topic>Endothelin-1 - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Hypoxia - diagnosis</topic><topic>Hypoxia - etiology</topic><topic>Lung diseases</topic><topic>Lung Diseases, Interstitial - complications</topic><topic>Lung Diseases, Interstitial - diagnosis</topic><topic>Lung Diseases, Interstitial - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Oximetry</topic><topic>Polysomnography - instrumentation</topic><topic>Respiratory diseases</topic><topic>Sleep - physiology</topic><topic>Sleep. Vigilance</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TRAKADA, Georgia</creatorcontrib><creatorcontrib>NIKOLAOU, Eugenia</creatorcontrib><creatorcontrib>POULI, Athanasia</creatorcontrib><creatorcontrib>TSIAMITA, Maria</creatorcontrib><creatorcontrib>SPIROPOULOS, Kostas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TRAKADA, Georgia</au><au>NIKOLAOU, Eugenia</au><au>POULI, Athanasia</au><au>TSIAMITA, Maria</au><au>SPIROPOULOS, Kostas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelin-1 levels in interstitial lung disease patients during sleep</atitle><jtitle>Sleep & breathing</jtitle><addtitle>Sleep Breath</addtitle><date>2003-09</date><risdate>2003</risdate><volume>7</volume><issue>3</issue><spage>111</spage><epage>118</epage><pages>111-118</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract><![CDATA[Hypoxemia stimulates endothelin-1 (ET-1) secretion. The reduction in alveolar ventilation during sleep is considered sufficient to account for the hypoxemia observed in patients with respiratory diseases.
The aim of this study was to evaluate the arterial ET-1 levels and their relationship with pulmonary hypertension in patients with interstitial lung disease (ILD) during sleep.
We examined 38 patients with ILD using formal polysomnography (electroencephalogram, electrocardiogram, airflow, respiratory muscle movement, oximeter) to detect the presence of nocturnal, nonapneic, oxyhemoglobin desaturation. All patients desaturated below a baseline sleep saturation of 90% for 5 minutes or more, reaching a nadir saturation of at least 85%. Each patient had already undergone right heart catheterization with a Swan-Ganz catheter for measuring hemodynamic parameters. Sampling of arterial blood from a radial artery line for determination of blood gases and ET-1 values was performed simultaneously, after 5 minutes of the first desaturation.
At rest, arterial ET-1 levels were higher in ILD patients (1.73 +/- 0.37 mgr/mL) than in controls (1.22 +/- 0.15 mgr/mL) ( p < 0.001). Also, the patients with pulmonary hypertension (Pa > 20 mm Hg) presented significantly higher arterial ET-1 levels (1.86 +/- 0.32 mgr/mL) than those without pulmonary hypertension (1.31 +/- 0.13 mgr/mL) ( p < 0.001). Arterial ET-1 levels were significantly correlated with mean pulmonary arterial pressure (PAP) (r = 0.749, p < 0.001), and arterial oxygen partial pressure (PaO2) (r = 0.79, p < 0.001). At sleep, during desaturation, arterial ET-1 levels significantly increased in all patients (2.46 +/- 0.13 mgr/mL) as compared with resting values ( p < 0.001). Arterial ET-1 levels were significantly correlated with PAP (r = 0.657, p < 0.001) and PaO2 (r = 0.93, p < 0.001).
According to our study, arterial ET-1 is markedly increased in ILD patients, especially in those with pulmonary hypertension.]]></abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>14569522</pmid><doi>10.1007/s11325-003-0111-y</doi><tpages>8</tpages></addata></record> |
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| subjects | Biological and medical sciences Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Electrocardiography Electroencephalography Endothelin-1 - metabolism Female Fundamental and applied biological sciences. Psychology Hemodynamics - physiology Humans Hypertension Hypertension, Pulmonary - complications Hypoxia - diagnosis Hypoxia - etiology Lung diseases Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - diagnosis Lung Diseases, Interstitial - metabolism Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Oximetry Polysomnography - instrumentation Respiratory diseases Sleep - physiology Sleep. Vigilance Vertebrates: nervous system and sense organs |
| title | Endothelin-1 levels in interstitial lung disease patients during sleep |
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