Mice Lacking Myeloid Differentiation Factor 88 Display Profound Defects in Host Resistance and Immune Responses to Mycobacterium avium Infection Not Exhibited by Toll-Like Receptor 2 (TLR2)- and TLR4-Deficient Animals

To assess the role of Toll-like receptor (TLR) signaling in host resistance to Mycobacterium avium infection, mice deficient in the TLR adaptor molecule myeloid differentiation factor 88 (MyD88), as well as TLR2(-/-) and TLR4(-/-) animals, were infected with a virulent strain of M. avium, and bacter...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-11, Vol.171 (9), p.4758-4764
Hauptverfasser:	Feng, Carl G, Scanga, Charles A, Collazo-Custodio, Carmen M, Cheever, Allen W, Hieny, Sara, Caspar, Patricia, Sher, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Antigens, Differentiation - genetics Antigens, Differentiation - physiology Cells, Cultured Cytokines - biosynthesis Down-Regulation - genetics Down-Regulation - immunology Immunity, Cellular - genetics Immunity, Innate - genetics Inflammation Mediators - metabolism Interferon-gamma - antagonists & inhibitors Interferon-gamma - biosynthesis Lung - immunology Lung - microbiology Lung - pathology Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Mice, Knockout Mycobacterium avium - growth & development Mycobacterium avium - immunology Myeloid Differentiation Factor 88 Neutrophil Infiltration - genetics Neutrophil Infiltration - immunology Receptors, Cell Surface - deficiency Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - physiology Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - microbiology Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors Tuberculoma - genetics Tuberculoma - immunology Tuberculoma - pathology Tuberculosis - genetics Tuberculosis - immunology Tuberculosis - mortality Tuberculosis - pathology
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