Effects of chronic murine and human leptin infusion on plasma leptin and corticosterone levels and energy balance in lean Zucker rats

SUMMARY Aim To clarify whether centrally delivered leptin can access the circulation and to determine to what extent the effects of i.c.v. h‐leptin and m‐leptin on body weight and plasma corticosterone are due to reduced food intake. Methods Male lean Zucker rats were infused i.c.v. with recombi...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2001-12, Vol.3 (6), p.435-442
Hauptverfasser:	Al-Barazanji, K. A., Buckingham, R. E., Arch, J. R. S., Briscoe, C., Jenkins, O., Tadayyon, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Animals body weight Brain - metabolism Carrier Proteins - genetics corticosterone Corticosterone - blood Energy Metabolism - drug effects Epididymis food intake Gene Expression Regulation - drug effects Humans Infusions, Intravenous Ion Channels leptin Leptin - administration & dosage Leptin - blood Leptin - pharmacology Male Membrane Proteins - genetics Mice Mitochondria - metabolism Mitochondrial Proteins Obesity - blood Obesity - genetics Obesity - metabolism Rats Rats, Zucker Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology RNA, Messenger - genetics Thinness Time Factors Transcription, Genetic - drug effects Uncoupling Protein 1
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