Inhibitory effect of a soluble transforming growth factor β type II receptor on the activation of rat hepatic stellate cells in primary culture

Background/Aims: Oxidative stress, including the generation of reactive oxygen species (ROS) that acts as a signaling mediator for transforming growth factor (TGF)-β, plays a key role in hepatic fibrosis. Hepatic stellate cells (HSCs) produce and respond to TGF-β in an autocrine manner with increase...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of hepatology 2003-11, Vol.39 (5), p.731-737
Hauptverfasser:	Cui, Xuezhi, Shimizu, Ichiro, Lu, Guangming, Itonaga, Mina, Inoue, Hiroshi, Shono, Masayuki, Tamaki, Katsuyoshi, Fukuno, Hiroshi, Ueno, Hikaru, Ito, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Cells, Cultured Gene Transfer Techniques Genetic Vectors Hepatic fibrosis Hepatic stellate cell Humans Intracellular Membranes - metabolism Lipid Peroxidation - physiology Liver - cytology Liver - metabolism Liver - physiology Male NAD - metabolism Oxidation-Reduction Oxidative stress Oxidative Stress - physiology Protein-Serine-Threonine Kinases Rats Rats, Wistar Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Receptor, Transforming Growth Factor-beta Type II Receptors, Transforming Growth Factor beta - chemistry Receptors, Transforming Growth Factor beta - metabolism Receptors, Transforming Growth Factor beta - physiology RNA, Messenger - antagonists & inhibitors Solubility Soluble transforming growth factor-β type II receptor Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - genetics Transforming Growth Factor beta1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!