A Combination of Tea (Camellia senensis) Catechins Is Required for Optimal Inhibition of Induced CYP1A Expression by Green Tea Extract
It was previously demonstrated that the commercial green tea extract Polyphenon 100 (P100), and to a lesser extent (−)-epigallocatechin-3-gallate (EGCG), partially antagonizes 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced transcription of human CYP1A1 (Williams, S. N.; Shih, H.; Guenette, D. K....
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2003-10, Vol.51 (22), p.6627-6634 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Williams, Susanne N Pickwell, George V Quattrochi, Linda C |
| description | It was previously demonstrated that the commercial green tea extract Polyphenon 100 (P100), and to a lesser extent (−)-epigallocatechin-3-gallate (EGCG), partially antagonizes 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced transcription of human CYP1A1 (Williams, S. N.; Shih, H.; Guenette, D. K.; Brackney, W.; Denison, M. S.; Pickwell, G. V.; Quattrochi, L. C. Chem.−Biol. Interact. 2000, 128, 211−229). Here, P100 is compared to a reconstituted mixture of the four major tea catechins (referred to as P100R) to determine whether inhibition was due to additional polyphenols in the extract or from synergistic interactions among the tea catechins. It was found that cotreatment of cells with TCDD and either P100 or P100R inhibited TCDD-induced CYP1A promoter-driven luciferase reporter activity (HepG2 cells) and CYP1A expression (HepG2 and primary human hepatocytes), similarly. These results indicate that modulation of human CYP1A expression by P100 can be attributed entirely to the combination of the four tea catechins. These findings may be important in the evaluation of future chemoprevention strategies using green tea and single catechin agents. Keywords: Green tea; Camellia senensis; polyphenols; catechins; cytochrome P450; CYP1A; human hepatocytes |
| doi_str_mv | 10.1021/jf030181z |
| format | Article |
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N.; Shih, H.; Guenette, D. K.; Brackney, W.; Denison, M. S.; Pickwell, G. V.; Quattrochi, L. C. Chem.−Biol. Interact. 2000, 128, 211−229). Here, P100 is compared to a reconstituted mixture of the four major tea catechins (referred to as P100R) to determine whether inhibition was due to additional polyphenols in the extract or from synergistic interactions among the tea catechins. It was found that cotreatment of cells with TCDD and either P100 or P100R inhibited TCDD-induced CYP1A promoter-driven luciferase reporter activity (HepG2 cells) and CYP1A expression (HepG2 and primary human hepatocytes), similarly. These results indicate that modulation of human CYP1A expression by P100 can be attributed entirely to the combination of the four tea catechins. These findings may be important in the evaluation of future chemoprevention strategies using green tea and single catechin agents. Keywords: Green tea; Camellia senensis; polyphenols; catechins; cytochrome P450; CYP1A; human hepatocytes</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf030181z</identifier><identifier>PMID: 14558788</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Bacterial Proteins - genetics ; Biological and medical sciences ; Camellia sinensis - chemistry ; Carcinogenesis, carcinogens and anticarcinogens ; Catechin - pharmacology ; Cell Death ; Cell Line ; Cytochrome P-450 CYP1A1 - genetics ; Foods and miscellaneous ; Gene Expression - drug effects ; Genes, Reporter - drug effects ; Hepatocytes - drug effects ; Humans ; Luminescent Proteins - genetics ; Medical sciences ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polychlorinated Dibenzodioxins - pharmacology ; Receptors, Aryl Hydrocarbon - genetics ; RNA, Messenger - analysis ; Tumors</subject><ispartof>Journal of agricultural and food chemistry, 2003-10, Vol.51 (22), p.6627-6634</ispartof><rights>Copyright © 2003 American Chemical Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a379t-c962646bbd54740e08884eac0799bfcb8b9c919a7b839215c3ca15f270ce4413</citedby><cites>FETCH-LOGICAL-a379t-c962646bbd54740e08884eac0799bfcb8b9c919a7b839215c3ca15f270ce4413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf030181z$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf030181z$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15209611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14558788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Susanne N</creatorcontrib><creatorcontrib>Pickwell, George V</creatorcontrib><creatorcontrib>Quattrochi, Linda C</creatorcontrib><title>A Combination of Tea (Camellia senensis) Catechins Is Required for Optimal Inhibition of Induced CYP1A Expression by Green Tea Extract</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>It was previously demonstrated that the commercial green tea extract Polyphenon 100 (P100), and to a lesser extent (−)-epigallocatechin-3-gallate (EGCG), partially antagonizes 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced transcription of human CYP1A1 (Williams, S. N.; Shih, H.; Guenette, D. K.; Brackney, W.; Denison, M. S.; Pickwell, G. V.; Quattrochi, L. C. Chem.−Biol. Interact. 2000, 128, 211−229). Here, P100 is compared to a reconstituted mixture of the four major tea catechins (referred to as P100R) to determine whether inhibition was due to additional polyphenols in the extract or from synergistic interactions among the tea catechins. It was found that cotreatment of cells with TCDD and either P100 or P100R inhibited TCDD-induced CYP1A promoter-driven luciferase reporter activity (HepG2 cells) and CYP1A expression (HepG2 and primary human hepatocytes), similarly. These results indicate that modulation of human CYP1A expression by P100 can be attributed entirely to the combination of the four tea catechins. These findings may be important in the evaluation of future chemoprevention strategies using green tea and single catechin agents. Keywords: Green tea; Camellia senensis; polyphenols; catechins; cytochrome P450; CYP1A; human hepatocytes</description><subject>Bacterial Proteins - genetics</subject><subject>Biological and medical sciences</subject><subject>Camellia sinensis - chemistry</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Catechin - pharmacology</subject><subject>Cell Death</subject><subject>Cell Line</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Foods and miscellaneous</subject><subject>Gene Expression - drug effects</subject><subject>Genes, Reporter - drug effects</subject><subject>Hepatocytes - drug effects</subject><subject>Humans</subject><subject>Luminescent Proteins - genetics</subject><subject>Medical sciences</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polychlorinated Dibenzodioxins - pharmacology</subject><subject>Receptors, Aryl Hydrocarbon - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>Tumors</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUFvEzEQhS0EoqFw4A8gX6joYcHeXa_tY7SkbaRKrSBChYtlO7Oqw8abenallB_A72ZDQnPhNIf36c2bN4S85ewjZzn_tGpYwbjiv56RCRc5ywTn6jmZsFHMlKj4CXmFuGKMKSHZS3LCSyGUVGpCfk9p3a1diLYPXaRdQxdg6YfarqFtg6UIESIGPKe17cHfh4h0jvQLPAwhwZI2XaI3mz6sbUvn8T648M9nHpeDH4n6-y2f0tl2kwBxp7lHepkA4t9Ns22frO9fkxeNbRHeHOYpWVzMFvVVdn1zOa-n15ktpO4zr6u8KivnlqKUJQOmlCrBeia1do13ymmvubbSqULnXPjCWy6aXDIPZcmLU3K2t92k7mEA7M06oB8vtRG6AY3kuc4LrUfwfA_61CEmaMwmjTemR8OZ2XVunjof2XcH08GtYXkkDyWPwPsDYNHbtkk2-oBHbvyYrvguXbbnAvawfdJt-mkqWUhhFrdfzcXd1ecfufpm7o6-1qNZdUOKY3X_CfgHrtijww</recordid><startdate>20031022</startdate><enddate>20031022</enddate><creator>Williams, Susanne N</creator><creator>Pickwell, George V</creator><creator>Quattrochi, Linda C</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031022</creationdate><title>A Combination of Tea (Camellia senensis) Catechins Is Required for Optimal Inhibition of Induced CYP1A Expression by Green Tea Extract</title><author>Williams, Susanne N ; Pickwell, George V ; Quattrochi, Linda C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a379t-c962646bbd54740e08884eac0799bfcb8b9c919a7b839215c3ca15f270ce4413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Bacterial Proteins - genetics</topic><topic>Biological and medical sciences</topic><topic>Camellia sinensis - chemistry</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Catechin - pharmacology</topic><topic>Cell Death</topic><topic>Cell Line</topic><topic>Cytochrome P-450 CYP1A1 - genetics</topic><topic>Foods and miscellaneous</topic><topic>Gene Expression - drug effects</topic><topic>Genes, Reporter - drug effects</topic><topic>Hepatocytes - drug effects</topic><topic>Humans</topic><topic>Luminescent Proteins - genetics</topic><topic>Medical sciences</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polychlorinated Dibenzodioxins - pharmacology</topic><topic>Receptors, Aryl Hydrocarbon - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Susanne N</creatorcontrib><creatorcontrib>Pickwell, George V</creatorcontrib><creatorcontrib>Quattrochi, Linda C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Susanne N</au><au>Pickwell, George V</au><au>Quattrochi, Linda C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Combination of Tea (Camellia senensis) Catechins Is Required for Optimal Inhibition of Induced CYP1A Expression by Green Tea Extract</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2003-10-22</date><risdate>2003</risdate><volume>51</volume><issue>22</issue><spage>6627</spage><epage>6634</epage><pages>6627-6634</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>It was previously demonstrated that the commercial green tea extract Polyphenon 100 (P100), and to a lesser extent (−)-epigallocatechin-3-gallate (EGCG), partially antagonizes 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced transcription of human CYP1A1 (Williams, S. N.; Shih, H.; Guenette, D. K.; Brackney, W.; Denison, M. S.; Pickwell, G. V.; Quattrochi, L. C. Chem.−Biol. Interact. 2000, 128, 211−229). Here, P100 is compared to a reconstituted mixture of the four major tea catechins (referred to as P100R) to determine whether inhibition was due to additional polyphenols in the extract or from synergistic interactions among the tea catechins. It was found that cotreatment of cells with TCDD and either P100 or P100R inhibited TCDD-induced CYP1A promoter-driven luciferase reporter activity (HepG2 cells) and CYP1A expression (HepG2 and primary human hepatocytes), similarly. These results indicate that modulation of human CYP1A expression by P100 can be attributed entirely to the combination of the four tea catechins. These findings may be important in the evaluation of future chemoprevention strategies using green tea and single catechin agents. Keywords: Green tea; Camellia senensis; polyphenols; catechins; cytochrome P450; CYP1A; human hepatocytes</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>14558788</pmid><doi>10.1021/jf030181z</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2003-10, Vol.51 (22), p.6627-6634 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Bacterial Proteins - genetics Biological and medical sciences Camellia sinensis - chemistry Carcinogenesis, carcinogens and anticarcinogens Catechin - pharmacology Cell Death Cell Line Cytochrome P-450 CYP1A1 - genetics Foods and miscellaneous Gene Expression - drug effects Genes, Reporter - drug effects Hepatocytes - drug effects Humans Luminescent Proteins - genetics Medical sciences Plant Extracts - chemistry Plant Extracts - pharmacology Polychlorinated Dibenzodioxins - pharmacology Receptors, Aryl Hydrocarbon - genetics RNA, Messenger - analysis Tumors |
| title | A Combination of Tea (Camellia senensis) Catechins Is Required for Optimal Inhibition of Induced CYP1A Expression by Green Tea Extract |
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