Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria

In this work, the topology of mitochondrial ▪ and H2O2 generation and their interplay with matrix GSH in isolated heart mitochondria were examined. We observed that complex I releases ▪ into the matrix (where it is converted to H2O2 by Mn-SOD) but not into the intermembrane space. No free radical ge...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular pharmacology 2003-11, Vol.64 (5), p.1136-1144
Hauptverfasser: Han, Derick, Canali, Raffaella, Rettori, Daniel, Kaplowitz, Neil
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!