Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria
In this work, the topology of mitochondrial ▪ and H2O2 generation and their interplay with matrix GSH in isolated heart mitochondria were examined. We observed that complex I releases ▪ into the matrix (where it is converted to H2O2 by Mn-SOD) but not into the intermembrane space. No free radical ge...
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Veröffentlicht in: | Molecular pharmacology 2003-11, Vol.64 (5), p.1136-1144 |
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Sprache: | eng |
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