Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma

In humans and in mice, control of the intracellular pathogen, Mycobacterium tuberculosis (Mtb), requires IFN-gamma. Although the adaptive immune response results in production of substantial amounts of IFN-gamma in response to Mtb, the immune response is unable to eradicate the infection in most cas...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-11, Vol.171 (9), p.4750-4757
Hauptverfasser:	Nagabhushanam, Vijaya, Solache, Alejandra, Ting, Li-Min, Escaron, Claire J, Zhang, Jennifer Y, Ernst, Joel D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - biosynthesis Carrier Proteins - physiology Cell Line Cells, Cultured Culture Media, Conditioned - pharmacology Down-Regulation - immunology Gene Expression Regulation - immunology Humans Immunity, Cellular Immunity, Innate Interferon-gamma - antagonists & inhibitors Interferon-gamma - physiology Interleukin-6 - biosynthesis Interleukin-6 - metabolism Interleukin-6 - physiology Intracellular Signaling Peptides and Proteins Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Mice Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Nuclear Proteins Protein Biosynthesis - immunology Proteins - physiology Repressor Proteins Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Trans-Activators - antagonists & inhibitors Trans-Activators - genetics Transcription Factors Transcriptional Activation - immunology
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