Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome
Cardiovascular disorders are common in patients with obstructive sleep apnoea syndrome (OSAS) but there is debate as to whether OSAS is an independent risk factor for their development, since OSAS may be associated with other disorders and risk factors that predispose to cardiovascular disease. In a...
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Veröffentlicht in: | The European respiratory journal 2000-07, Vol.16 (1), p.128-133 |
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description | Cardiovascular disorders are common in patients with obstructive sleep apnoea syndrome (OSAS) but there is debate as to whether OSAS is an independent risk factor for their development, since OSAS may be associated with other disorders and risk factors that predispose to cardiovascular disease.
In an effort to quantify the risk of OSAS patients for cardiovascular disease arising from these other factors, the authors assessed the future risk for cardiovascular disease among a group of 114 consecutive patients with established OSAS prior to nasal continuous positive airway pressure therapy, using an established method of risk prediction employed in the Framingham studies.
Patients were 100 males, aged (mean±sd) 52±9.0 yrs, and 14 females, aged 51±10.4 yrs, with an apnoea/hypopnoea index of 45±22·h‐1. Based on either a prior diagnosis, or a mean of three resting blood pressure recordings >140 mmHg systolic and/or 90 diastolic, 68% of patients were hypertensive. Only 18% were current smokers, while 16% had either diabetes mellitus or impaired glucose tolerance, and 63% had elevated fasting cholesterol and/or triglyceride levels. The estimated 10‐yr risk of a coronary heart disease (CHD) event in males was (mean±sem) 13.9±0.9%, 95% confidence interval (95% CI) 12.1–16.0, and for a stroke was 12.3±1.4%; 95% CI 9.4–15.1, with a combined 10 yr risk for stroke and CHD events of 32.9±2.7%; 95% CI 27.8–38.5 in males aged >53 yrs.
These findings indicate that obstructive sleep apnoea syndrome patients are at high risk of future cardiovascular disease from factors other than obstructive sleep apnoea syndrome, and may help explain the difficulties in identifying a potential independent risk from obstructive sleep apnoea syndrome. |
doi_str_mv | 10.1034/j.1399-3003.2000.16a23.x |
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In an effort to quantify the risk of OSAS patients for cardiovascular disease arising from these other factors, the authors assessed the future risk for cardiovascular disease among a group of 114 consecutive patients with established OSAS prior to nasal continuous positive airway pressure therapy, using an established method of risk prediction employed in the Framingham studies.
Patients were 100 males, aged (mean±sd) 52±9.0 yrs, and 14 females, aged 51±10.4 yrs, with an apnoea/hypopnoea index of 45±22·h‐1. Based on either a prior diagnosis, or a mean of three resting blood pressure recordings >140 mmHg systolic and/or 90 diastolic, 68% of patients were hypertensive. Only 18% were current smokers, while 16% had either diabetes mellitus or impaired glucose tolerance, and 63% had elevated fasting cholesterol and/or triglyceride levels. The estimated 10‐yr risk of a coronary heart disease (CHD) event in males was (mean±sem) 13.9±0.9%, 95% confidence interval (95% CI) 12.1–16.0, and for a stroke was 12.3±1.4%; 95% CI 9.4–15.1, with a combined 10 yr risk for stroke and CHD events of 32.9±2.7%; 95% CI 27.8–38.5 in males aged >53 yrs.
These findings indicate that obstructive sleep apnoea syndrome patients are at high risk of future cardiovascular disease from factors other than obstructive sleep apnoea syndrome, and may help explain the difficulties in identifying a potential independent risk from obstructive sleep apnoea syndrome.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1034/j.1399-3003.2000.16a23.x</identifier><identifier>PMID: 10933098</identifier><language>eng</language><publisher>Sheffield: Eur Respiratory Soc</publisher><subject>Biological and medical sciences ; Blood Pressure ; Coronary Disease - etiology ; Coronary heart disease ; Female ; Humans ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Prospective Studies ; Respiratory system : syndromes and miscellaneous diseases ; Risk Factors ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; sleep apnoea ; Smoking ; stroke ; Stroke - etiology</subject><ispartof>The European respiratory journal, 2000-07, Vol.16 (1), p.128-133</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4753-ec9d0a550944503e00929ec44d5b8411ae02af1203a93da78b0235f8bb2922563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1399-3003.2000.16a23.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1417094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10933098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiely, JL</creatorcontrib><creatorcontrib>McNicholas, WT</creatorcontrib><title>Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Cardiovascular disorders are common in patients with obstructive sleep apnoea syndrome (OSAS) but there is debate as to whether OSAS is an independent risk factor for their development, since OSAS may be associated with other disorders and risk factors that predispose to cardiovascular disease.
In an effort to quantify the risk of OSAS patients for cardiovascular disease arising from these other factors, the authors assessed the future risk for cardiovascular disease among a group of 114 consecutive patients with established OSAS prior to nasal continuous positive airway pressure therapy, using an established method of risk prediction employed in the Framingham studies.
Patients were 100 males, aged (mean±sd) 52±9.0 yrs, and 14 females, aged 51±10.4 yrs, with an apnoea/hypopnoea index of 45±22·h‐1. Based on either a prior diagnosis, or a mean of three resting blood pressure recordings >140 mmHg systolic and/or 90 diastolic, 68% of patients were hypertensive. Only 18% were current smokers, while 16% had either diabetes mellitus or impaired glucose tolerance, and 63% had elevated fasting cholesterol and/or triglyceride levels. The estimated 10‐yr risk of a coronary heart disease (CHD) event in males was (mean±sem) 13.9±0.9%, 95% confidence interval (95% CI) 12.1–16.0, and for a stroke was 12.3±1.4%; 95% CI 9.4–15.1, with a combined 10 yr risk for stroke and CHD events of 32.9±2.7%; 95% CI 27.8–38.5 in males aged >53 yrs.
These findings indicate that obstructive sleep apnoea syndrome patients are at high risk of future cardiovascular disease from factors other than obstructive sleep apnoea syndrome, and may help explain the difficulties in identifying a potential independent risk from obstructive sleep apnoea syndrome.</description><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Coronary Disease - etiology</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Prospective Studies</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk Factors</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>sleep apnoea</subject><subject>Smoking</subject><subject>stroke</subject><subject>Stroke - etiology</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2P0zAQhi0EYrsLfwH5ANxSxh9J4wvSqlpY0AokBGdrkkyoi_OBnWy3_x6XVMARydJI9jPveB7GuIC1AKXf7NdCGZMpALWWAOm2QKnWD4_Y6s_DY7YCAyoTRhUX7DLGPYAotBJP2YUAoxSYcsU-bTE0brjHWM8eAw8u_uAt1tMQInc9H3Fy1E-RH9y040MVpzDXk7snHj3RyHHsB0Iej30Tho6esSct-kjPz_WKfXt383V7m919fv9he32X1XqTq4xq0wDmORitc1AEYKShWusmr0otBBJIbIUEhUY1uCkrkCpvy6qSRsq8UFfs9ZI7huHnTHGynYs1eY89DXO0GyFNOmUCywWswxBjoNaOwXUYjlaAPbm0e3tSZk_K7Mml_e3SPqTWF-cZc9VR80_jIi8BL89Asoe-DdjXLv7ltNikBRP2dsEOztPxv-fbmy8fRXEtVQp4tQTs3PfdwQWysUPv07eEpbAXhRVWyFL9AkH4nJE</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Kiely, JL</creator><creator>McNicholas, WT</creator><general>Eur Respiratory Soc</general><general>Munksgaard International Publishers</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200007</creationdate><title>Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome</title><author>Kiely, JL ; McNicholas, WT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4753-ec9d0a550944503e00929ec44d5b8411ae02af1203a93da78b0235f8bb2922563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Coronary Disease - etiology</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Prospective Studies</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk Factors</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>sleep apnoea</topic><topic>Smoking</topic><topic>stroke</topic><topic>Stroke - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiely, JL</creatorcontrib><creatorcontrib>McNicholas, WT</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiely, JL</au><au>McNicholas, WT</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2000-07</date><risdate>2000</risdate><volume>16</volume><issue>1</issue><spage>128</spage><epage>133</epage><pages>128-133</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Cardiovascular disorders are common in patients with obstructive sleep apnoea syndrome (OSAS) but there is debate as to whether OSAS is an independent risk factor for their development, since OSAS may be associated with other disorders and risk factors that predispose to cardiovascular disease.
In an effort to quantify the risk of OSAS patients for cardiovascular disease arising from these other factors, the authors assessed the future risk for cardiovascular disease among a group of 114 consecutive patients with established OSAS prior to nasal continuous positive airway pressure therapy, using an established method of risk prediction employed in the Framingham studies.
Patients were 100 males, aged (mean±sd) 52±9.0 yrs, and 14 females, aged 51±10.4 yrs, with an apnoea/hypopnoea index of 45±22·h‐1. Based on either a prior diagnosis, or a mean of three resting blood pressure recordings >140 mmHg systolic and/or 90 diastolic, 68% of patients were hypertensive. Only 18% were current smokers, while 16% had either diabetes mellitus or impaired glucose tolerance, and 63% had elevated fasting cholesterol and/or triglyceride levels. The estimated 10‐yr risk of a coronary heart disease (CHD) event in males was (mean±sem) 13.9±0.9%, 95% confidence interval (95% CI) 12.1–16.0, and for a stroke was 12.3±1.4%; 95% CI 9.4–15.1, with a combined 10 yr risk for stroke and CHD events of 32.9±2.7%; 95% CI 27.8–38.5 in males aged >53 yrs.
These findings indicate that obstructive sleep apnoea syndrome patients are at high risk of future cardiovascular disease from factors other than obstructive sleep apnoea syndrome, and may help explain the difficulties in identifying a potential independent risk from obstructive sleep apnoea syndrome.</abstract><cop>Sheffield</cop><pub>Eur Respiratory Soc</pub><pmid>10933098</pmid><doi>10.1034/j.1399-3003.2000.16a23.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biological and medical sciences Blood Pressure Coronary Disease - etiology Coronary heart disease Female Humans Lipids - blood Male Medical sciences Middle Aged Pneumology Prospective Studies Respiratory system : syndromes and miscellaneous diseases Risk Factors Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology sleep apnoea Smoking stroke Stroke - etiology |
title | Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome |
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