Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester

5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor. However, the knowledge on selective accumulation of ALA-induced protoporphyrin IX (PpIX) in brain tumor tissue is still fragment. In the present study, the rat C6 glioma cells, human SK-N-SH neurobl...

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Veröffentlicht in:	Cancer letters 2003-10, Vol.200 (2), p.123-131
Hauptverfasser:	Wu, S.M., Ren, Q.G., Zhou, M.O., Peng, Q., Chen, J.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aminolevulinic Acid Animals Antineoplastic agents Biological and medical sciences Brain cancer Brain Neoplasms - metabolism Cell Line Cerebellum - metabolism Efficiency Experiments Glioma - metabolism Human SK-N-SH neuroblastoma cells Humans Light Medical sciences Microscopy Neuroblastoma - metabolism Pharmacology. Drug treatments Photosensitizing Agents - pharmacology Protoporphyrin IX Protoporphyrins - metabolism Protoporphyrins - pharmacology Rat C6 glioma cells Rat normal cerebellar granule cells Rats Tumor Cells, Cultured Tumors
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