Cellular aging-dependent decrease in cholesterol in membrane microdomains of human diploid fibroblasts

Recently it has been shown that cholesterol plays indispensable roles in the function of cholesterol-rich microdomains (rafts), such as in ligand-mediated signal transduction. Using a perfringolysin O derivative (BCθ) that binds selectively to cholesterol in rafts without causing membrane damage (Pr...

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Veröffentlicht in:	Experimental cell research 2003-11, Vol.290 (2), p.381-390
Hauptverfasser:	Nakamura, Megumi, Kondo, Hiroshi, Shimada, Yukiko, Waheed, Abdul A, Ohno-Iwashita, Yoshiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bacterial Toxins - pharmacology beta-Galactosidase - metabolism Cells, Cultured Cellular aging Cellular Senescence Cholesterol Cholesterol - metabolism Diploidy Female Fibroblasts - drug effects Fibroblasts - metabolism Humans Hydroxyurea - pharmacology Infant Lipid rafts Lipoproteins - metabolism Lung - metabolism Membrane Microdomains - drug effects Membrane Microdomains - metabolism Microscopy, Immunoelectron Perfringolysin O Replicative senescence
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