Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors

The idea that excitatory amino acid transporters (EAATs) can control the activation of specific metabotropic glutamate receptors (mGluRs) was investigated in rat hippocampal slices. Using the accumulation of inositol phosphates as a measure of group I mGluR activity, we have shown that the broad spe...

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Veröffentlicht in:	Neuropharmacology 2003-12, Vol.45 (7), p.885-894
Hauptverfasser:	Selkirk, J.V., Naeve, G.S., Foster, A.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - pharmacology Benzoates - pharmacology Biological and medical sciences Colforsin - pharmacology Cyclic AMP Cyclic AMP - biosynthesis Excitatory Amino Acid Antagonists - pharmacology Excitatory amino acid transporter Excitatory Amino Acid Transporter 1 - antagonists & inhibitors Excitatory Amino Acid Transporter 1 - metabolism Excitatory Amino Acid Transporter 2 - antagonists & inhibitors Excitatory Amino Acid Transporter 2 - metabolism Fundamental and applied biological sciences. Psychology Glycine - analogs & derivatives Glycine - pharmacology Hippocampus Hippocampus - drug effects Hippocampus - metabolism In Vitro Techniques Inositol 1,4,5-Trisphosphate - metabolism Inositol phosphates Male Medical sciences Metabotropic glutamate receptor Methoxyhydroxyphenylglycol - analogs & derivatives Methoxyhydroxyphenylglycol - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyridines - pharmacology Quisqualic Acid - metabolism Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - metabolism
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