MRI measurements of the pons and cerebellum in children born preterm; associations with the severity of periventricular leukomalacia and perinatal risk factors
Our purpose was to measure the size of the pons and cerebellum in preterm babies with periventricular leukomalacia (PVL), and to study their relationship with the severity of PVL and with perinatal risk factors. We examined 33 premature children, mean gestational age 31 weeks, range 26-36 weeks with...
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| Veröffentlicht in: | Neuroradiology 2003-10, Vol.45 (10), p.730-734 |
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| creator | ARGYROPOULOU, M. I XYDIS, V DROUGIA, A ARGYROPOULOU, P. I TZOUFI, M BASSOUNAS, A ANDRONIKOU, S EFREMIDIS, S. C |
| description | Our purpose was to measure the size of the pons and cerebellum in preterm babies with periventricular leukomalacia (PVL), and to study their relationship with the severity of PVL and with perinatal risk factors. We examined 33 premature children, mean gestational age 31 weeks, range 26-36 weeks with PVL on MRI, and 27 full-term controls. On MRI at 0.4-5.5 years (mean 1.4 years) we measured the area of the corpus callosum and vermis, the anteroposterior diameter of the pons and the volume of the cerebellum. The area of the corpus callosum was used as a marker of white matter loss and PVL severity. All regional brain measurements except that of the vermis were significantly lower in patients than controls: corpus callosum (mm(2)): 239.6+/-92.5 vs 434.8+/-126.8, P |
| doi_str_mv | 10.1007/s00234-003-1067-0 |
| format | Article |
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I ; XYDIS, V ; DROUGIA, A ; ARGYROPOULOU, P. I ; TZOUFI, M ; BASSOUNAS, A ; ANDRONIKOU, S ; EFREMIDIS, S. C</creator><creatorcontrib>ARGYROPOULOU, M. I ; XYDIS, V ; DROUGIA, A ; ARGYROPOULOU, P. I ; TZOUFI, M ; BASSOUNAS, A ; ANDRONIKOU, S ; EFREMIDIS, S. C</creatorcontrib><description><![CDATA[Our purpose was to measure the size of the pons and cerebellum in preterm babies with periventricular leukomalacia (PVL), and to study their relationship with the severity of PVL and with perinatal risk factors. We examined 33 premature children, mean gestational age 31 weeks, range 26-36 weeks with PVL on MRI, and 27 full-term controls. On MRI at 0.4-5.5 years (mean 1.4 years) we measured the area of the corpus callosum and vermis, the anteroposterior diameter of the pons and the volume of the cerebellum. The area of the corpus callosum was used as a marker of white matter loss and PVL severity. All regional brain measurements except that of the vermis were significantly lower in patients than controls: corpus callosum (mm(2)): 239.6+/-92.5 vs 434.8+/-126.8, P <0.01; pons (mm): 14.8+/-3.0 vs 17.9+/-1.4, P <0.01]; cerebellum (cm(3)): 68.2+/-31.6 vs 100.6+/-28.3, P <0.01; vermis (mm(2)): 808.1+/-292.2 vs 942.2+/-246.2, NS. Significant reduction in the area of the vermis: 411.3+/-203.3 vs 935+/-252.6 mm(2); cerebellar volume: 16.3+/-12.5 vs 96.6+/-20.2 mm(3); and the diameter of the pons: 10.1+/-2.2 vs 17.5+/-1.3 mm ( P<0.01) were observed in seven children with gestational age < or =28 weeks, severe hypotension and large patent ductus arteriosus (PDA). There was a significant correlation between the duration of mechanical ventilation and the size of the vermis, pons and cerebellum (R=-0.65, -0.57 and -0.73, respectively, P <0.01).]]></description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-003-1067-0</identifier><identifier>PMID: 12942217</identifier><identifier>CODEN: NRDYAB</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Case-Control Studies ; Cerebellum - pathology ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Leukomalacia, Periventricular - diagnosis ; Leukomalacia, Periventricular - etiology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Neurology ; Pons - pathology ; Risk Factors ; Severity of Illness Index ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Neuroradiology, 2003-10, Vol.45 (10), p.730-734</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-46d2333bd7502d0ea8f6946bb0fafa320906fbdb6e28f2267f931269f142fc243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15230759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12942217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARGYROPOULOU, M. I</creatorcontrib><creatorcontrib>XYDIS, V</creatorcontrib><creatorcontrib>DROUGIA, A</creatorcontrib><creatorcontrib>ARGYROPOULOU, P. I</creatorcontrib><creatorcontrib>TZOUFI, M</creatorcontrib><creatorcontrib>BASSOUNAS, A</creatorcontrib><creatorcontrib>ANDRONIKOU, S</creatorcontrib><creatorcontrib>EFREMIDIS, S. C</creatorcontrib><title>MRI measurements of the pons and cerebellum in children born preterm; associations with the severity of periventricular leukomalacia and perinatal risk factors</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><description><![CDATA[Our purpose was to measure the size of the pons and cerebellum in preterm babies with periventricular leukomalacia (PVL), and to study their relationship with the severity of PVL and with perinatal risk factors. We examined 33 premature children, mean gestational age 31 weeks, range 26-36 weeks with PVL on MRI, and 27 full-term controls. On MRI at 0.4-5.5 years (mean 1.4 years) we measured the area of the corpus callosum and vermis, the anteroposterior diameter of the pons and the volume of the cerebellum. The area of the corpus callosum was used as a marker of white matter loss and PVL severity. All regional brain measurements except that of the vermis were significantly lower in patients than controls: corpus callosum (mm(2)): 239.6+/-92.5 vs 434.8+/-126.8, P <0.01; pons (mm): 14.8+/-3.0 vs 17.9+/-1.4, P <0.01]; cerebellum (cm(3)): 68.2+/-31.6 vs 100.6+/-28.3, P <0.01; vermis (mm(2)): 808.1+/-292.2 vs 942.2+/-246.2, NS. Significant reduction in the area of the vermis: 411.3+/-203.3 vs 935+/-252.6 mm(2); cerebellar volume: 16.3+/-12.5 vs 96.6+/-20.2 mm(3); and the diameter of the pons: 10.1+/-2.2 vs 17.5+/-1.3 mm ( P<0.01) were observed in seven children with gestational age < or =28 weeks, severe hypotension and large patent ductus arteriosus (PDA). There was a significant correlation between the duration of mechanical ventilation and the size of the vermis, pons and cerebellum (R=-0.65, -0.57 and -0.73, respectively, P <0.01).]]></description><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cerebellum - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Leukomalacia, Periventricular - diagnosis</subject><subject>Leukomalacia, Periventricular - etiology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Pons - pathology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1TAQhS0EopfCA7BB3sAuZWznxolYoarQSkVICNbRxBnrmuYPj1PUp-FVcXqv1NWMNN85o5kjxFsFFwrAfmQAbcoCwBQKKlvAM7FTpdGFajQ8F7s8rgvTlHAmXjH_hgxaY1-KM6WbUmtld-Lftx83ciTkNdJIU2I5e5kOJJd5YolTLx1F6mgY1lGGSbpDGPpIk-zmOMklUqI4fpLIPLuAKWyqvyEdHj2Y7imG9LB5Lrm7zwticOuAUQ603s0jDphlj3s2YMKEg4yB76RHl-bIr8ULjwPTm1M9F7--XP28vC5uv3-9ufx8WzijbSrKqtfGmK63e9A9ENa-asqq68CjR6Ohgcp3fVeRrr3WlfWNUbpqvCq1d7o05-LD0XeJ85-VOLVjYJfPxonmlVurdF03qs6gOoIuzsyRfLvEMGJ8aBW0WyrtMZU2P7vdUmkha96dzNdupP5JcYohA-9PALLDwUecXOAnbq8N2H1j_gNyCJh_</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>ARGYROPOULOU, M. I</creator><creator>XYDIS, V</creator><creator>DROUGIA, A</creator><creator>ARGYROPOULOU, P. I</creator><creator>TZOUFI, M</creator><creator>BASSOUNAS, A</creator><creator>ANDRONIKOU, S</creator><creator>EFREMIDIS, S. C</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>MRI measurements of the pons and cerebellum in children born preterm; associations with the severity of periventricular leukomalacia and perinatal risk factors</title><author>ARGYROPOULOU, M. I ; XYDIS, V ; DROUGIA, A ; ARGYROPOULOU, P. I ; TZOUFI, M ; BASSOUNAS, A ; ANDRONIKOU, S ; EFREMIDIS, S. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-46d2333bd7502d0ea8f6946bb0fafa320906fbdb6e28f2267f931269f142fc243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cerebellum - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Leukomalacia, Periventricular - diagnosis</topic><topic>Leukomalacia, Periventricular - etiology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Pons - pathology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARGYROPOULOU, M. I</creatorcontrib><creatorcontrib>XYDIS, V</creatorcontrib><creatorcontrib>DROUGIA, A</creatorcontrib><creatorcontrib>ARGYROPOULOU, P. I</creatorcontrib><creatorcontrib>TZOUFI, M</creatorcontrib><creatorcontrib>BASSOUNAS, A</creatorcontrib><creatorcontrib>ANDRONIKOU, S</creatorcontrib><creatorcontrib>EFREMIDIS, S. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARGYROPOULOU, M. I</au><au>XYDIS, V</au><au>DROUGIA, A</au><au>ARGYROPOULOU, P. I</au><au>TZOUFI, M</au><au>BASSOUNAS, A</au><au>ANDRONIKOU, S</au><au>EFREMIDIS, S. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI measurements of the pons and cerebellum in children born preterm; associations with the severity of periventricular leukomalacia and perinatal risk factors</atitle><jtitle>Neuroradiology</jtitle><addtitle>Neuroradiology</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>45</volume><issue>10</issue><spage>730</spage><epage>734</epage><pages>730-734</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><coden>NRDYAB</coden><abstract><![CDATA[Our purpose was to measure the size of the pons and cerebellum in preterm babies with periventricular leukomalacia (PVL), and to study their relationship with the severity of PVL and with perinatal risk factors. We examined 33 premature children, mean gestational age 31 weeks, range 26-36 weeks with PVL on MRI, and 27 full-term controls. On MRI at 0.4-5.5 years (mean 1.4 years) we measured the area of the corpus callosum and vermis, the anteroposterior diameter of the pons and the volume of the cerebellum. The area of the corpus callosum was used as a marker of white matter loss and PVL severity. All regional brain measurements except that of the vermis were significantly lower in patients than controls: corpus callosum (mm(2)): 239.6+/-92.5 vs 434.8+/-126.8, P <0.01; pons (mm): 14.8+/-3.0 vs 17.9+/-1.4, P <0.01]; cerebellum (cm(3)): 68.2+/-31.6 vs 100.6+/-28.3, P <0.01; vermis (mm(2)): 808.1+/-292.2 vs 942.2+/-246.2, NS. Significant reduction in the area of the vermis: 411.3+/-203.3 vs 935+/-252.6 mm(2); cerebellar volume: 16.3+/-12.5 vs 96.6+/-20.2 mm(3); and the diameter of the pons: 10.1+/-2.2 vs 17.5+/-1.3 mm ( P<0.01) were observed in seven children with gestational age < or =28 weeks, severe hypotension and large patent ductus arteriosus (PDA). There was a significant correlation between the duration of mechanical ventilation and the size of the vermis, pons and cerebellum (R=-0.65, -0.57 and -0.73, respectively, P <0.01).]]></abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12942217</pmid><doi>10.1007/s00234-003-1067-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Case-Control Studies Cerebellum - pathology Female Humans Infant Infant, Newborn Infant, Premature Leukomalacia, Periventricular - diagnosis Leukomalacia, Periventricular - etiology Magnetic Resonance Imaging Male Medical sciences Neurology Pons - pathology Risk Factors Severity of Illness Index Vascular diseases and vascular malformations of the nervous system |
| title | MRI measurements of the pons and cerebellum in children born preterm; associations with the severity of periventricular leukomalacia and perinatal risk factors |
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