Translational Control of Inducible Nitric Oxide Synthase by IL-13 and Arginine Availability in Inflammatory Macrophages

Inducible NO synthase (iNOS) and its generation of NO from L-arginine are subject to transcriptional as well as posttranscriptional control by cytokines. In this study, we describe a novel, translational mechanism of iNOS regulation by arginine availability. Using mouse inflammatory peritoneal macro...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-11, Vol.171 (9), p.4561-4568
Hauptverfasser:	El-Gayar, Stefan, Thuring-Nahler, Heike, Pfeilschifter, Josef, Rollinghoff, Martin, Bogdan, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginase - antagonists & inhibitors Arginase - biosynthesis Arginine - analogs & derivatives Arginine - deficiency Arginine - metabolism Arginine - pharmacology Arginine - physiology Ascitic Fluid - enzymology Ascitic Fluid - immunology Ascitic Fluid - pathology Cell Count Cells, Cultured Culture Media, Conditioned Dose-Response Relationship, Immunologic Enzyme Inhibitors - pharmacology Enzyme Stability Female Interleukin-13 - physiology Macrophages, Peritoneal - enzymology Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mice Nitric Oxide - biosynthesis Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Protein Biosynthesis - immunology
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