Involvement of Serum Response Factor Isoforms in Myofibroblast Differentiation During Bleomycin-Induced Lung Injury

Serum response factor (SRF) is a transcription factor essential for smooth muscle (SM) myogenesis. Its role in myofibroblast differentiation is, however, unknown. We studied the expression and the localization of SRF in bleomycin-induced pulmonary fibrosis, where myofibroblasts are abundant. We foun...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2003-11, Vol.29 (5), p.583-590
Hauptverfasser:	Yang, Yan, Zhe, Xiaoning, Phan, Sem H, Ullenbruch, Matt, Schuger, Lucia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - pharmacology Bleomycin - adverse effects Bleomycin - pharmacology Cell Differentiation - physiology Female Fibroblasts - physiology Lung - drug effects Mice Protein Isoforms Serum Response Factor - genetics Serum Response Factor - metabolism
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