Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin
The exact mechanism of a chronic nonproductive cough is sometimes unclear when patients who are without symptoms or signs indicating the major causes of chronic cough remain undiagnosed. We hypothesized that some neurochemical alterations in the sensory nerves in the cough reflex may occur in the up...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2003-10, Vol.112 (4), p.695-701 |
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| creator | Cho, You Sook Park, So-Yeon Lee, Chang-Keun Yoo, Bin Moon, Hee-Bom |
| description | The exact mechanism of a chronic nonproductive cough is sometimes unclear when patients who are without symptoms or signs indicating the major causes of chronic cough remain undiagnosed.
We hypothesized that some neurochemical alterations in the sensory nerves in the cough reflex may occur in the upper airway of chronic nonproductive cough patients.
We took nasal lavage fluid (NLF) specimens from 38 patients with a chronic nonproductive cough as the sole presenting symptom. All 38 had normal chest radiography, spirometry, and bronchial responsiveness. We likewise took NLF specimens from 14 healthy control subjects. We used a capsaicin cough provocation test to determine cough sensitivity and considered the value of C
5 (the lowest capsaicin concentration inducing 5 consecutive coughs) as an index of cough sensitivity. We measured levels of substance P of NLF specimens by using ELISA. In addition, we evaluated the clinical response of each patient after subsequent therapeutic trials with an antihistamine and decongestant for 2 weeks.
By using capsaicin cough sensitivity as the basis for grouping the study subjects, we divided the patients into 2 groups: an increased cough sensitivity group (ICS, C
5 |
| doi_str_mv | 10.1016/S0091-6749(03)01784-6 |
| format | Article |
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We hypothesized that some neurochemical alterations in the sensory nerves in the cough reflex may occur in the upper airway of chronic nonproductive cough patients.
We took nasal lavage fluid (NLF) specimens from 38 patients with a chronic nonproductive cough as the sole presenting symptom. All 38 had normal chest radiography, spirometry, and bronchial responsiveness. We likewise took NLF specimens from 14 healthy control subjects. We used a capsaicin cough provocation test to determine cough sensitivity and considered the value of C
5 (the lowest capsaicin concentration inducing 5 consecutive coughs) as an index of cough sensitivity. We measured levels of substance P of NLF specimens by using ELISA. In addition, we evaluated the clinical response of each patient after subsequent therapeutic trials with an antihistamine and decongestant for 2 weeks.
By using capsaicin cough sensitivity as the basis for grouping the study subjects, we divided the patients into 2 groups: an increased cough sensitivity group (ICS, C
5 <32 μmol/L) and a normal cough sensitivity (NCS) group. Patients with ICS showed an elevated SP concentration in NLF (median value, 408 pg/mL) compared with that of the NCS group (237 pg/mL) and the control subjects (138 pg/mL) (
P < .01). The median value of the percentage of remnant cough after therapeutic trial compared with the cough status before treatment was significantly higher in the ICS subgroup (70%) than that of NCS (25%) (
P < .05).
Elevated substance P contents in NLF specimens were associated with ICS in patients with chronic nonproductive cough, suggesting a neurochemical abnormality in the upper airway.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/S0091-6749(03)01784-6</identifier><identifier>PMID: 14564346</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Administration, Inhalation ; Adult ; Biological and medical sciences ; Capsaicin - administration & dosage ; Case-Control Studies ; Cetirizine - therapeutic use ; Chronic Disease ; Cough - diagnosis ; Cough - drug therapy ; Cough - etiology ; Cough - metabolism ; Cough syndrome ; Disease Susceptibility ; Ephedrine - therapeutic use ; Female ; Histamine H1 Antagonists, Non-Sedating - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Nasal Decongestants - therapeutic use ; Nasal Lavage Fluid - chemistry ; Nasal Provocation Tests ; Neuropepetide ; Osmolar Concentration ; Patients ; Pneumology ; Radiography ; Respiratory diseases ; Respiratory system : syndromes and miscellaneous diseases ; Sensory hyperreactivity ; Substance P - analysis ; Viral infections</subject><ispartof>Journal of allergy and clinical immunology, 2003-10, Vol.112 (4), p.695-701</ispartof><rights>2003 Mosby, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-b396053fa18ac66fcfab24e6f48c767b2cc66956f53d0f3f925db2974ec3a5b83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674903017846$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15205979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14564346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, You Sook</creatorcontrib><creatorcontrib>Park, So-Yeon</creatorcontrib><creatorcontrib>Lee, Chang-Keun</creatorcontrib><creatorcontrib>Yoo, Bin</creatorcontrib><creatorcontrib>Moon, Hee-Bom</creatorcontrib><title>Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>The exact mechanism of a chronic nonproductive cough is sometimes unclear when patients who are without symptoms or signs indicating the major causes of chronic cough remain undiagnosed.
We hypothesized that some neurochemical alterations in the sensory nerves in the cough reflex may occur in the upper airway of chronic nonproductive cough patients.
We took nasal lavage fluid (NLF) specimens from 38 patients with a chronic nonproductive cough as the sole presenting symptom. All 38 had normal chest radiography, spirometry, and bronchial responsiveness. We likewise took NLF specimens from 14 healthy control subjects. We used a capsaicin cough provocation test to determine cough sensitivity and considered the value of C
5 (the lowest capsaicin concentration inducing 5 consecutive coughs) as an index of cough sensitivity. We measured levels of substance P of NLF specimens by using ELISA. In addition, we evaluated the clinical response of each patient after subsequent therapeutic trials with an antihistamine and decongestant for 2 weeks.
By using capsaicin cough sensitivity as the basis for grouping the study subjects, we divided the patients into 2 groups: an increased cough sensitivity group (ICS, C
5 <32 μmol/L) and a normal cough sensitivity (NCS) group. Patients with ICS showed an elevated SP concentration in NLF (median value, 408 pg/mL) compared with that of the NCS group (237 pg/mL) and the control subjects (138 pg/mL) (
P < .01). The median value of the percentage of remnant cough after therapeutic trial compared with the cough status before treatment was significantly higher in the ICS subgroup (70%) than that of NCS (25%) (
P < .05).
Elevated substance P contents in NLF specimens were associated with ICS in patients with chronic nonproductive cough, suggesting a neurochemical abnormality in the upper airway.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Capsaicin - administration & dosage</subject><subject>Case-Control Studies</subject><subject>Cetirizine - therapeutic use</subject><subject>Chronic Disease</subject><subject>Cough - diagnosis</subject><subject>Cough - drug therapy</subject><subject>Cough - etiology</subject><subject>Cough - metabolism</subject><subject>Cough syndrome</subject><subject>Disease Susceptibility</subject><subject>Ephedrine - therapeutic use</subject><subject>Female</subject><subject>Histamine H1 Antagonists, Non-Sedating - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nasal Decongestants - therapeutic use</subject><subject>Nasal Lavage Fluid - chemistry</subject><subject>Nasal Provocation Tests</subject><subject>Neuropepetide</subject><subject>Osmolar Concentration</subject><subject>Patients</subject><subject>Pneumology</subject><subject>Radiography</subject><subject>Respiratory diseases</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sensory hyperreactivity</subject><subject>Substance P - analysis</subject><subject>Viral infections</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhgdR7Fr9CUpAFL0YTSaTr6sipX5AQUG9DmcySTdlNrPmZFb6R_y9ZruLBW96FfKe55yc8DTNc0bfMcrk---UGtZK1Zs3lL-lTOm-lQ-aFaNGtVJ34mGz-oecNE8Qr2m9c20eNyesF7LnvVw1fy4mv4PiR4LLgAWS8-QbqZmfkMREEiBMZIIdXHkSpiWOSEKeN2QLJfpUkPyOZU3cOs8pOpLmtM3zuLgSd564eblaE0hjneSyB6zPHDL0CWNlYrkhZa7lNUz7ImwRoovpafMowIT-2fE8bX5-vPhx_rm9_Prpy_mHy9aJjpd24EZSwQMwDU7K4AIMXe9l6LVTUg2dq6kRMgg-0sCD6cQ4dEb13nEQg-anzevD3Lr1r8VjsZuIzk8TJD8vaBXrtOaK3gsybYTqqKrgy__A63nJqX7CMkF7zUVneKXEgXJ5Rsw-2G2OG8g3llG792tv_dq9PEu5vfVrZe17cZy-DBs_3nUdhVbg1REAdDCFXI1GvONER4VRpnJnB6569rvos0VXfTo_xuxdseMc71nlL6Z1xL4</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Cho, You Sook</creator><creator>Park, So-Yeon</creator><creator>Lee, Chang-Keun</creator><creator>Yoo, Bin</creator><creator>Moon, Hee-Bom</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin</title><author>Cho, You Sook ; Park, So-Yeon ; Lee, Chang-Keun ; Yoo, Bin ; Moon, Hee-Bom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-b396053fa18ac66fcfab24e6f48c767b2cc66956f53d0f3f925db2974ec3a5b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Capsaicin - administration & dosage</topic><topic>Case-Control Studies</topic><topic>Cetirizine - therapeutic use</topic><topic>Chronic Disease</topic><topic>Cough - diagnosis</topic><topic>Cough - drug therapy</topic><topic>Cough - etiology</topic><topic>Cough - metabolism</topic><topic>Cough syndrome</topic><topic>Disease Susceptibility</topic><topic>Ephedrine - therapeutic use</topic><topic>Female</topic><topic>Histamine H1 Antagonists, Non-Sedating - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nasal Decongestants - therapeutic use</topic><topic>Nasal Lavage Fluid - chemistry</topic><topic>Nasal Provocation Tests</topic><topic>Neuropepetide</topic><topic>Osmolar Concentration</topic><topic>Patients</topic><topic>Pneumology</topic><topic>Radiography</topic><topic>Respiratory diseases</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sensory hyperreactivity</topic><topic>Substance P - analysis</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, You Sook</creatorcontrib><creatorcontrib>Park, So-Yeon</creatorcontrib><creatorcontrib>Lee, Chang-Keun</creatorcontrib><creatorcontrib>Yoo, Bin</creatorcontrib><creatorcontrib>Moon, Hee-Bom</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, You Sook</au><au>Park, So-Yeon</au><au>Lee, Chang-Keun</au><au>Yoo, Bin</au><au>Moon, Hee-Bom</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>112</volume><issue>4</issue><spage>695</spage><epage>701</epage><pages>695-701</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>The exact mechanism of a chronic nonproductive cough is sometimes unclear when patients who are without symptoms or signs indicating the major causes of chronic cough remain undiagnosed.
We hypothesized that some neurochemical alterations in the sensory nerves in the cough reflex may occur in the upper airway of chronic nonproductive cough patients.
We took nasal lavage fluid (NLF) specimens from 38 patients with a chronic nonproductive cough as the sole presenting symptom. All 38 had normal chest radiography, spirometry, and bronchial responsiveness. We likewise took NLF specimens from 14 healthy control subjects. We used a capsaicin cough provocation test to determine cough sensitivity and considered the value of C
5 (the lowest capsaicin concentration inducing 5 consecutive coughs) as an index of cough sensitivity. We measured levels of substance P of NLF specimens by using ELISA. In addition, we evaluated the clinical response of each patient after subsequent therapeutic trials with an antihistamine and decongestant for 2 weeks.
By using capsaicin cough sensitivity as the basis for grouping the study subjects, we divided the patients into 2 groups: an increased cough sensitivity group (ICS, C
5 <32 μmol/L) and a normal cough sensitivity (NCS) group. Patients with ICS showed an elevated SP concentration in NLF (median value, 408 pg/mL) compared with that of the NCS group (237 pg/mL) and the control subjects (138 pg/mL) (
P < .01). The median value of the percentage of remnant cough after therapeutic trial compared with the cough status before treatment was significantly higher in the ICS subgroup (70%) than that of NCS (25%) (
P < .05).
Elevated substance P contents in NLF specimens were associated with ICS in patients with chronic nonproductive cough, suggesting a neurochemical abnormality in the upper airway.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>14564346</pmid><doi>10.1016/S0091-6749(03)01784-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Inhalation Adult Biological and medical sciences Capsaicin - administration & dosage Case-Control Studies Cetirizine - therapeutic use Chronic Disease Cough - diagnosis Cough - drug therapy Cough - etiology Cough - metabolism Cough syndrome Disease Susceptibility Ephedrine - therapeutic use Female Histamine H1 Antagonists, Non-Sedating - therapeutic use Humans Male Medical sciences Middle Aged Nasal Decongestants - therapeutic use Nasal Lavage Fluid - chemistry Nasal Provocation Tests Neuropepetide Osmolar Concentration Patients Pneumology Radiography Respiratory diseases Respiratory system : syndromes and miscellaneous diseases Sensory hyperreactivity Substance P - analysis Viral infections |
| title | Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin |
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