Constitution and telomere dynamics of bone marrow stromal cells in patients undergoing allogeneic bone marrow transplantation
We evaluated the genotypic origin of mesenchymal stem cells (MSC) following sex-mismatched allogeneic bone marrow transplantation (BMT), and investigated the telomere dynamics in MSC in normal individuals and patients after BMT. The study population consisted of 11 patients with hematologic disorder...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2003-11, Vol.32 (9), p.947-952 |
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| creator | LEE, J.-J NAM, C.-E KOOK, H MACIEJEWSKI, J. P KIM, Y.-K CHUNG, I.-J PARK, K.-S LEE, I.-K HWANG, T.-J KIM, H.-J |
| description | We evaluated the genotypic origin of mesenchymal stem cells (MSC) following sex-mismatched allogeneic bone marrow transplantation (BMT), and investigated the telomere dynamics in MSC in normal individuals and patients after BMT. The study population consisted of 11 patients with hematologic disorders who showed complete chimerism after BMT. Telomere length was measured in MSC using Southern blotting analysis in eight patients and 18 healthy subjects as a control group. Following culture, MSC were identified by the expression of SH2 and SH4, and lack of CD14, CD34, and CD45. All MSC showed the recipient genotype, based on the results of fluorescent in situ hybridization analysis using X-chromosome satellite probes or microsatellite DNA polymorphism analysis. The mean telomere length in MSC from normal controls was 7.2+/-0.53 kb (range, 6.12-7.78), and progressive telomere shortening was seen with age. There was no significant difference in MSC telomere length between the BMT group and age-matched controls. This study confirmed that the MSC isolated from the recipients of allogeneic BMT did not have the donor genotype, despite complete chimerism. Moreover, MSC were demonstrated to show progressive loss of telomere length with age, but the telomeres in MSC were not affected by BMT. |
| doi_str_mv | 10.1038/sj.bmt.1704253 |
| format | Article |
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P ; KIM, Y.-K ; CHUNG, I.-J ; PARK, K.-S ; LEE, I.-K ; HWANG, T.-J ; KIM, H.-J</creator><creatorcontrib>LEE, J.-J ; NAM, C.-E ; KOOK, H ; MACIEJEWSKI, J. P ; KIM, Y.-K ; CHUNG, I.-J ; PARK, K.-S ; LEE, I.-K ; HWANG, T.-J ; KIM, H.-J</creatorcontrib><description>We evaluated the genotypic origin of mesenchymal stem cells (MSC) following sex-mismatched allogeneic bone marrow transplantation (BMT), and investigated the telomere dynamics in MSC in normal individuals and patients after BMT. The study population consisted of 11 patients with hematologic disorders who showed complete chimerism after BMT. Telomere length was measured in MSC using Southern blotting analysis in eight patients and 18 healthy subjects as a control group. Following culture, MSC were identified by the expression of SH2 and SH4, and lack of CD14, CD34, and CD45. All MSC showed the recipient genotype, based on the results of fluorescent in situ hybridization analysis using X-chromosome satellite probes or microsatellite DNA polymorphism analysis. The mean telomere length in MSC from normal controls was 7.2+/-0.53 kb (range, 6.12-7.78), and progressive telomere shortening was seen with age. There was no significant difference in MSC telomere length between the BMT group and age-matched controls. This study confirmed that the MSC isolated from the recipients of allogeneic BMT did not have the donor genotype, despite complete chimerism. Moreover, MSC were demonstrated to show progressive loss of telomere length with age, but the telomeres in MSC were not affected by BMT.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1704253</identifier><identifier>PMID: 14561997</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adolescent ; Adult ; Age ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; B cells ; Biological and medical sciences ; Bone marrow ; Bone Marrow Cells ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Case-Control Studies ; CD14 antigen ; CD34 antigen ; CD45 antigen ; Cell culture ; Cells, Cultured ; Child ; Chimerism ; DNA probes ; Female ; Fluorescence ; Fluorescence in situ hybridization ; Gene polymorphism ; Genotype ; Health aspects ; Hematologic Diseases - therapy ; Hematological diseases ; Humans ; Hybridization analysis ; Male ; Medical sciences ; Mesenchymal Stromal Cells - cytology ; Mesenchyme ; Physiological aspects ; Polymorphism ; Population studies ; Satellite DNA ; Southern blotting ; Stem cell transplantation ; Stem cells ; Stromal cells ; Stromal Cells - cytology ; Telomere - metabolism ; Telomeres ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation Chimera ; Transplantation, Homologous ; Yeast</subject><ispartof>Bone marrow transplantation (Basingstoke), 2003-11, Vol.32 (9), p.947-952</ispartof><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2003</rights><rights>Nature Publishing Group 2003.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-db110cc740907498e9dc94983f718c83057256a3509ac0bdb71389aae2a4b89b3</citedby><cites>FETCH-LOGICAL-c529t-db110cc740907498e9dc94983f718c83057256a3509ac0bdb71389aae2a4b89b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15205936$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14561997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEE, J.-J</creatorcontrib><creatorcontrib>NAM, C.-E</creatorcontrib><creatorcontrib>KOOK, H</creatorcontrib><creatorcontrib>MACIEJEWSKI, J. P</creatorcontrib><creatorcontrib>KIM, Y.-K</creatorcontrib><creatorcontrib>CHUNG, I.-J</creatorcontrib><creatorcontrib>PARK, K.-S</creatorcontrib><creatorcontrib>LEE, I.-K</creatorcontrib><creatorcontrib>HWANG, T.-J</creatorcontrib><creatorcontrib>KIM, H.-J</creatorcontrib><title>Constitution and telomere dynamics of bone marrow stromal cells in patients undergoing allogeneic bone marrow transplantation</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>We evaluated the genotypic origin of mesenchymal stem cells (MSC) following sex-mismatched allogeneic bone marrow transplantation (BMT), and investigated the telomere dynamics in MSC in normal individuals and patients after BMT. The study population consisted of 11 patients with hematologic disorders who showed complete chimerism after BMT. Telomere length was measured in MSC using Southern blotting analysis in eight patients and 18 healthy subjects as a control group. Following culture, MSC were identified by the expression of SH2 and SH4, and lack of CD14, CD34, and CD45. All MSC showed the recipient genotype, based on the results of fluorescent in situ hybridization analysis using X-chromosome satellite probes or microsatellite DNA polymorphism analysis. The mean telomere length in MSC from normal controls was 7.2+/-0.53 kb (range, 6.12-7.78), and progressive telomere shortening was seen with age. There was no significant difference in MSC telomere length between the BMT group and age-matched controls. This study confirmed that the MSC isolated from the recipients of allogeneic BMT did not have the donor genotype, despite complete chimerism. Moreover, MSC were demonstrated to show progressive loss of telomere length with age, but the telomeres in MSC were not affected by BMT.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>B cells</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Case-Control Studies</subject><subject>CD14 antigen</subject><subject>CD34 antigen</subject><subject>CD45 antigen</subject><subject>Cell culture</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Chimerism</subject><subject>DNA probes</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene polymorphism</subject><subject>Genotype</subject><subject>Health aspects</subject><subject>Hematologic Diseases - therapy</subject><subject>Hematological diseases</subject><subject>Humans</subject><subject>Hybridization analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchyme</subject><subject>Physiological aspects</subject><subject>Polymorphism</subject><subject>Population studies</subject><subject>Satellite DNA</subject><subject>Southern blotting</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stromal cells</subject><subject>Stromal Cells - cytology</subject><subject>Telomere - metabolism</subject><subject>Telomeres</subject><subject>Transfusions. 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P</au><au>KIM, Y.-K</au><au>CHUNG, I.-J</au><au>PARK, K.-S</au><au>LEE, I.-K</au><au>HWANG, T.-J</au><au>KIM, H.-J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Constitution and telomere dynamics of bone marrow stromal cells in patients undergoing allogeneic bone marrow transplantation</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><addtitle>Bone Marrow Transplant</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>32</volume><issue>9</issue><spage>947</spage><epage>952</epage><pages>947-952</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>We evaluated the genotypic origin of mesenchymal stem cells (MSC) following sex-mismatched allogeneic bone marrow transplantation (BMT), and investigated the telomere dynamics in MSC in normal individuals and patients after BMT. The study population consisted of 11 patients with hematologic disorders who showed complete chimerism after BMT. Telomere length was measured in MSC using Southern blotting analysis in eight patients and 18 healthy subjects as a control group. Following culture, MSC were identified by the expression of SH2 and SH4, and lack of CD14, CD34, and CD45. All MSC showed the recipient genotype, based on the results of fluorescent in situ hybridization analysis using X-chromosome satellite probes or microsatellite DNA polymorphism analysis. The mean telomere length in MSC from normal controls was 7.2+/-0.53 kb (range, 6.12-7.78), and progressive telomere shortening was seen with age. There was no significant difference in MSC telomere length between the BMT group and age-matched controls. This study confirmed that the MSC isolated from the recipients of allogeneic BMT did not have the donor genotype, despite complete chimerism. Moreover, MSC were demonstrated to show progressive loss of telomere length with age, but the telomeres in MSC were not affected by BMT.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>14561997</pmid><doi>10.1038/sj.bmt.1704253</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2003-11, Vol.32 (9), p.947-952 |
| issn | 0268-3369 1476-5365 |
| language | eng |
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| source | MEDLINE; Nature; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adolescent Adult Age Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy B cells Biological and medical sciences Bone marrow Bone Marrow Cells Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Case-Control Studies CD14 antigen CD34 antigen CD45 antigen Cell culture Cells, Cultured Child Chimerism DNA probes Female Fluorescence Fluorescence in situ hybridization Gene polymorphism Genotype Health aspects Hematologic Diseases - therapy Hematological diseases Humans Hybridization analysis Male Medical sciences Mesenchymal Stromal Cells - cytology Mesenchyme Physiological aspects Polymorphism Population studies Satellite DNA Southern blotting Stem cell transplantation Stem cells Stromal cells Stromal Cells - cytology Telomere - metabolism Telomeres Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Chimera Transplantation, Homologous Yeast |
| title | Constitution and telomere dynamics of bone marrow stromal cells in patients undergoing allogeneic bone marrow transplantation |
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