Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate
Recent glycobiology studies have suggested fundamental biological functions for chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as glycosaminoglycan sidechains of proteoglycans in the extracellular matrix and at cell surfaces. They have been implicated in the sign...
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| Veröffentlicht in: | Current opinion in structural biology 2003-10, Vol.13 (5), p.612-620 |
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| container_title | Current opinion in structural biology |
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| creator | Sugahara, Kazuyuki Mikami, Tadahisa Uyama, Toru Mizuguchi, Souhei Nomura, Kazuya Kitagawa, Hiroshi |
| description | Recent glycobiology studies have suggested fundamental biological functions for chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as glycosaminoglycan sidechains of proteoglycans in the extracellular matrix and at cell surfaces. They have been implicated in the signaling functions of various heparin-binding growth factors and chemokines, and play critical roles in the development of the central nervous system. They also function as receptors for various pathogens. These functions are closely associated with the sulfation patterns of the glycosaminoglycan chains. Surprisingly, nonsulfated chondroitin is indispensable in the morphogenesis and cell division of
Caenorhabditis elegans, as revealed by RNA interference experiments of the recently cloned
chondroitin synthase gene and by the analysis of mutants of
squashed vulva genes. |
| doi_str_mv | 10.1016/j.sbi.2003.09.011 |
| format | Article |
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Caenorhabditis elegans, as revealed by RNA interference experiments of the recently cloned
chondroitin synthase gene and by the analysis of mutants of
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Caenorhabditis elegans, as revealed by RNA interference experiments of the recently cloned
chondroitin synthase gene and by the analysis of mutants of
squashed vulva genes.</description><subject>Animals</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Caenorhabditis elegans - cytology</subject><subject>Caenorhabditis elegans - growth & development</subject><subject>Cell Division - physiology</subject><subject>Chondroitin Sulfates - chemistry</subject><subject>Chondroitin Sulfates - metabolism</subject><subject>Dermatan Sulfate - chemistry</subject><subject>Dermatan Sulfate - metabolism</subject><subject>Growth Substances - metabolism</subject><subject>Heparitin Sulfate - chemistry</subject><subject>Heparitin Sulfate - metabolism</subject><subject>Morphogenesis - physiology</subject><subject>Nerve Regeneration - physiology</subject><subject>Neurites - metabolism</subject><subject>Neurons - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Structure-Activity Relationship</subject><issn>0959-440X</issn><issn>1879-033X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFr3DAQRkVJaTZpf0AvRafc7MzYli3RUwlpEwgUSgO5CVkaNVq8VirJgfz7OOyS3prTwPC-d3iMfUaoEbA_39Z5DHUD0NagakB8xzYoB1VB294dsQ0ooaqug7tjdpLzFgB67OQHdoyd6GWPw4bd_iJLc-HGPZrZUuZh5uWeeC5psWVJZuJjiFP888Sj5_Y-zi7FUFYqL5M3hbiZHXeUdqaY1-dH9t6bKdOnwz1lt98vf19cVTc_f1xffLupbNf1pWo8WeeFGZXwzaisaSUq2UgrlXHeDEoQiMGNouu8GNB6CeSB-kahQSTRnrKzvfchxb8L5aJ3IVuaJjNTXLIesJEDSHwTRCmlUNCvIO5Bm2LOibx-SGFn0pNG0C_R9Vav0fVLdA1Kr9HXzZeDfBl35P4tDpVX4OseoLXFY6Cksw205nYhkS3axfAf_TN1RJOh</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Sugahara, Kazuyuki</creator><creator>Mikami, Tadahisa</creator><creator>Uyama, Toru</creator><creator>Mizuguchi, Souhei</creator><creator>Nomura, Kazuya</creator><creator>Kitagawa, Hiroshi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate</title><author>Sugahara, Kazuyuki ; 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chondroitin synthase gene and by the analysis of mutants of
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| ispartof | Current opinion in structural biology, 2003-10, Vol.13 (5), p.612-620 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Brain - growth & development Brain - metabolism Caenorhabditis elegans - cytology Caenorhabditis elegans - growth & development Cell Division - physiology Chondroitin Sulfates - chemistry Chondroitin Sulfates - metabolism Dermatan Sulfate - chemistry Dermatan Sulfate - metabolism Growth Substances - metabolism Heparitin Sulfate - chemistry Heparitin Sulfate - metabolism Morphogenesis - physiology Nerve Regeneration - physiology Neurites - metabolism Neurons - metabolism Signal Transduction - physiology Structure-Activity Relationship |
| title | Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate |
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