Preclinical Evaluation of Targeted Cytotoxic Luteinizing Hormone-Releasing Hormone Analogue AN-152 in Androgen-Sensitive and Insensitive Prostate Cancers

Purpose and Experimental Design: To improve conventional chemotherapy, we developed cytotoxic analogues of luteinizing hormone-releasing hormone (LH-RH), which can be targeted to prostate cancers expressing LH-RH receptors. In view of pending clinical trials on cytotoxic LH-RH analogue AN-152, conta...

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Veröffentlicht in:	Clinical cancer research 2003-10, Vol.9 (12), p.4505-4513
Hauptverfasser:	LETSCH, Markus, SCHALLY, Andrew V, SZEPESHAZI, Karoly, HALMOS, Gabor, NAGY, Attila
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - physiology Animals Antineoplastic agents Antineoplastic Agents, Hormonal - pharmacology Apoptosis - drug effects Biological and medical sciences Chemotherapy Doxorubicin - analogs & derivatives Doxorubicin - pharmacology Drug Evaluation, Preclinical Gonadotropin-Releasing Hormone - agonists Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Humans Male Medical sciences Mice Mice, Nude Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - pathology Peptide Fragments - pharmacology Pharmacology. Drug treatments Prostate-Specific Antigen - blood Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Prostatic Neoplasms - secondary Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - metabolism Receptors, LHRH - genetics Receptors, LHRH - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Transplantation, Heterologous Triptorelin Pamoate - pharmacology Tumor Cells, Cultured
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