The lipid layer: the outer surface of the ocular surface tear film

The lipid layer: the outer surface of the ocular surface tear film

The outer layer of the tear film--the lipid layer--has numerous functions. It is a composite monolayer composed of a polar phase with surfactant properties and a nonpolar phase. In order to achieve an effective lipid layer, the nonpolar phase, which retards water vapor transmission, is dependent on...

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Veröffentlicht in:Bioscience reports 2001-08, Vol.21 (4), p.407-418
Hauptverfasser: McCulley, J P, Shine, W E
Format: Artikel
Sprache:eng
Schlagworte:
Humans
In Vitro Techniques
Lipid Metabolism
Lipids - chemistry
Models, Biological
Surface Properties
Tears - chemistry
Tears - metabolism
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Shine, W E
description The outer layer of the tear film--the lipid layer--has numerous functions. It is a composite monolayer composed of a polar phase with surfactant properties and a nonpolar phase. In order to achieve an effective lipid layer, the nonpolar phase, which retards water vapor transmission, is dependent on a properly structured polar phase. Additionally, this composite lipid layer must maintain its integrity during a blink. The phases of the lipid layer depend on both lipid type as well as fatty acid and alcohol composition for functionality. Surprisingly, the importance of the composition of the aqueous layer of the tear film in proper structuring of the lipid layer has not been recognized. Finally, lipid layer abnormalities and their relationship to ocular disease are beginning to be clarified.
doi_str_mv 10.1023/a:1017987608937
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source MEDLINE; SpringerNature Journals
subjects Humans
In Vitro Techniques
Lipid Metabolism
Lipids - chemistry
Models, Biological
Surface Properties
Tears - chemistry
Tears - metabolism
title The lipid layer: the outer surface of the ocular surface tear film
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