Cloning of CnLYSO1, a novel extracellular lysophospholipase of the pathogenic fungus Cryptococcus neoformans

We cloned a novel lysophospholipase ( CnLYSO1) from Cryptococcus neoformans var. grubii by PCR amplification and a cDNA library screen. The open reading frame (ORF) of 1278 nucleotides coded for a predicted 426-amino-acid protein (CnLyso1p) with two highly conserved GXSXG lipase-specific catalytic m...

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Veröffentlicht in:	Gene 2003-10, Vol.316, p.67-78
Hauptverfasser:	Coe, John G.S, Wilson, Christabel F, Sorrell, Tania C, Latouche, Nicolas G, Wright, Lesley C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Cell Division - genetics Cloning, Molecular Cryptococcus neoformans Cryptococcus neoformans - classification Cryptococcus neoformans - enzymology Cryptococcus neoformans - genetics Deletion mutant DNA, Complementary - chemistry DNA, Complementary - genetics Extracellular Space - enzymology Gene Expression Regulation, Enzymologic Gene Expression Regulation, Fungal LYSO1 gene Lysophospholipase - genetics Lysophospholipase - metabolism Molecular Sequence Data Mutation Phospholipase PLB1 gene Polyclonal antibodies Secretion Sequence Analysis, DNA Sequence Deletion Sequence Homology, Amino Acid Serotyping Virulence
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