FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice

We studied the role of FGF-2 on regulation of neurogenesis and cell loss in the granule cell layer (GCL) of the hippocampal dentate gyrus after experimental traumatic brain injury (TBI). In both FGF-2(-/-) and FGF-2(+/+) mice subjected to controlled cortical impact, the number of dividing cells labe...

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Veröffentlicht in:	The Journal of clinical investigation 2003-10, Vol.112 (8), p.1202-1210
Hauptverfasser:	Yoshimura, Shinichi, Teramoto, Tetsuyuki, Whalen, Michael J, Irizarry, Michael C, Takagi, Yasushi, Qiu, Jianhua, Harada, Jun, Waeber, Christian, Breakefield, Xandra O, Moskowitz, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Biomedical research Brain Injuries - physiopathology Bromodeoxyuridine - metabolism Cell Differentiation Dentate Gyrus - physiopathology Enzymes Female Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - physiology Gene Transfer, Horizontal Genetic engineering Growth factors Herpes viruses Hippocampus - metabolism Immunoassay Ischemia Laboratory animals Mice Mice, Inbred C57BL Nerve Degeneration - etiology Neurogenesis Neurons Neurons - physiology Trauma Traumatic brain injury Whole-Body Irradiation
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