Staying on the job: the frontal lobes control individual performance variability
The causes of variability of performance by individual subjects have rarely been investigated, although excessive variability or inconsistency may be a functionally significant factor for many real‐life activities. Our objective was to determine whether patients with focal frontal brain lesions have...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 2003-11, Vol.126 (11), p.2363-2380 |
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| container_title | Brain (London, England : 1878) |
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| creator | Stuss, Donald T. Murphy, Kelly J. Binns, Malcolm A. Alexander, Michael P. |
| description | The causes of variability of performance by individual subjects have rarely been investigated, although excessive variability or inconsistency may be a functionally significant factor for many real‐life activities. Our objective was to determine whether patients with focal frontal brain lesions have excessive individual performance variability. Thirty‐six patients with focal frontal (n = 25) or non‐frontal (n = 11) lesions were compared with 12 control subjects on different measures of intra‐individual variability: dispersion within a testing session; and consistency across testing sessions. Four reaction time tasks, varying in levels of complexity and based on a model of detection using feature integration, were administered. Following the first test session, 22 patients and 10 controls returned for two subsequent test sessions, which permitted the assessment of consistency of performance. Measures of abnormal dispersion of performance on these tests were observed in frontal patients only (except those with exclusively inferior medial damage). Disturbances in consistency of performance were observed primarily in patients with frontal lesions. Damage to the frontal lobes impairs the stability of cognitive performance. Damage to different frontal regions causes different profiles of abnormal variability. Fluctuations in performance of a task may underlie some of the reported difficulties in daily tasks reported by patients with frontal injuries. |
| doi_str_mv | 10.1093/brain/awg237 |
| format | Article |
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Our objective was to determine whether patients with focal frontal brain lesions have excessive individual performance variability. Thirty‐six patients with focal frontal (n = 25) or non‐frontal (n = 11) lesions were compared with 12 control subjects on different measures of intra‐individual variability: dispersion within a testing session; and consistency across testing sessions. Four reaction time tasks, varying in levels of complexity and based on a model of detection using feature integration, were administered. Following the first test session, 22 patients and 10 controls returned for two subsequent test sessions, which permitted the assessment of consistency of performance. Measures of abnormal dispersion of performance on these tests were observed in frontal patients only (except those with exclusively inferior medial damage). Disturbances in consistency of performance were observed primarily in patients with frontal lesions. Damage to the frontal lobes impairs the stability of cognitive performance. Damage to different frontal regions causes different profiles of abnormal variability. Fluctuations in performance of a task may underlie some of the reported difficulties in daily tasks reported by patients with frontal injuries.</description><identifier>ISSN: 0006-8950</identifier><identifier>ISSN: 1460-2156</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/awg237</identifier><identifier>PMID: 12876148</identifier><identifier>CODEN: BRAIAK</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Attention ; Biological and medical sciences ; Brain Diseases - parasitology ; Brain Diseases - physiopathology ; Brain Diseases - psychology ; CTL = control ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; DL = dorsolateral ; Female ; Frontal Lobe - injuries ; Frontal Lobe - pathology ; Frontal Lobe - physiopathology ; frontal lobes ; Humans ; ICV = intra‐individual coefficient of variation ; IIV = intra‐individual variability ; IM = inferior medial ; individual differences ; Injuries of the nervous system and the skull. Diseases due to physical agents ; intra‐individual variability ; ISD = intra‐individual standard deviation ; LDL = left dorsolateral ; Male ; Medical sciences ; Middle Aged ; Neurology ; Neuropsychological Tests ; NF = non‐frontal ; RDL = right dorsolateral ; Reaction Time ; Reproducibility of Results ; RT = reaction time ; SM = superior medial ; Stroke - physiopathology ; Stroke - psychology ; TBI = traumatic brain injury ; Traumas. Diseases due to physical agents ; TSI = time since injury</subject><ispartof>Brain (London, England : 1878), 2003-11, Vol.126 (11), p.2363-2380</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Nov 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-e68311bdb9c821702de8d3659378669f2a628dd680ef8f71956a4c15a67ae47b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15209708$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12876148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stuss, Donald T.</creatorcontrib><creatorcontrib>Murphy, Kelly J.</creatorcontrib><creatorcontrib>Binns, Malcolm A.</creatorcontrib><creatorcontrib>Alexander, Michael P.</creatorcontrib><title>Staying on the job: the frontal lobes control individual performance variability</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>The causes of variability of performance by individual subjects have rarely been investigated, although excessive variability or inconsistency may be a functionally significant factor for many real‐life activities. Our objective was to determine whether patients with focal frontal brain lesions have excessive individual performance variability. Thirty‐six patients with focal frontal (n = 25) or non‐frontal (n = 11) lesions were compared with 12 control subjects on different measures of intra‐individual variability: dispersion within a testing session; and consistency across testing sessions. Four reaction time tasks, varying in levels of complexity and based on a model of detection using feature integration, were administered. Following the first test session, 22 patients and 10 controls returned for two subsequent test sessions, which permitted the assessment of consistency of performance. Measures of abnormal dispersion of performance on these tests were observed in frontal patients only (except those with exclusively inferior medial damage). Disturbances in consistency of performance were observed primarily in patients with frontal lesions. Damage to the frontal lobes impairs the stability of cognitive performance. Damage to different frontal regions causes different profiles of abnormal variability. Fluctuations in performance of a task may underlie some of the reported difficulties in daily tasks reported by patients with frontal injuries.</description><subject>Adult</subject><subject>Aged</subject><subject>Attention</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - parasitology</subject><subject>Brain Diseases - physiopathology</subject><subject>Brain Diseases - psychology</subject><subject>CTL = control</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>DL = dorsolateral</subject><subject>Female</subject><subject>Frontal Lobe - injuries</subject><subject>Frontal Lobe - pathology</subject><subject>Frontal Lobe - physiopathology</subject><subject>frontal lobes</subject><subject>Humans</subject><subject>ICV = intra‐individual coefficient of variation</subject><subject>IIV = intra‐individual variability</subject><subject>IM = inferior medial</subject><subject>individual differences</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>intra‐individual variability</subject><subject>ISD = intra‐individual standard deviation</subject><subject>LDL = left dorsolateral</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>NF = non‐frontal</subject><subject>RDL = right dorsolateral</subject><subject>Reaction Time</subject><subject>Reproducibility of Results</subject><subject>RT = reaction time</subject><subject>SM = superior medial</subject><subject>Stroke - physiopathology</subject><subject>Stroke - psychology</subject><subject>TBI = traumatic brain injury</subject><subject>Traumas. Diseases due to physical agents</subject><subject>TSI = time since injury</subject><issn>0006-8950</issn><issn>1460-2156</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYBvAgil1Xb55lEOrJafMmky9vpahbKK30A8RLeGcmU7POTtZkpnb_-6bdxYIXT0l4fzzw5iHkLdADoIYf1hH9cIh_bhhXz8gMKklLBkI-JzNKqSy1EXSPvEppSSlUnMmXZA-YVhIqPSPfLkfc-OGmCEMx_nTFMtSfHi9dDMOIfdGH2qWiyY8Y-sIPrb_17ZQHaxe7EFc4NK64xeix9r0fN6_Jiw775N7szjm5_vL56nhRnp5_PTk-Oi0bAWosndQcoG5r02gGirLW6ZZLYbjSUpqOoWS6baWmrtOdAiMkVg0IlApdpWo-Jx-2uesYfk8ujXblU-P6HgcXpmRV3pFrxf4LwUDFDIgM3_8Dl2GKQ14iG1FxY3LinHzcoiaGlKLr7Dr6FcaNBWof-rCPfdhtH5m_22VO9cq1T3hXQAb7O4Cpwb6L-T99enKCUaPogyu3zqfR3f2dY_xlpeJK2MX3H5ZeyDNqFmA5vwf3uqKr</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Stuss, Donald T.</creator><creator>Murphy, Kelly J.</creator><creator>Binns, Malcolm A.</creator><creator>Alexander, Michael P.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Staying on the job: the frontal lobes control individual performance variability</title><author>Stuss, Donald T. ; Murphy, Kelly J. ; Binns, Malcolm A. ; Alexander, Michael P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-e68311bdb9c821702de8d3659378669f2a628dd680ef8f71956a4c15a67ae47b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Attention</topic><topic>Biological and medical sciences</topic><topic>Brain Diseases - parasitology</topic><topic>Brain Diseases - physiopathology</topic><topic>Brain Diseases - psychology</topic><topic>CTL = control</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>DL = dorsolateral</topic><topic>Female</topic><topic>Frontal Lobe - injuries</topic><topic>Frontal Lobe - pathology</topic><topic>Frontal Lobe - physiopathology</topic><topic>frontal lobes</topic><topic>Humans</topic><topic>ICV = intra‐individual coefficient of variation</topic><topic>IIV = intra‐individual variability</topic><topic>IM = inferior medial</topic><topic>individual differences</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>intra‐individual variability</topic><topic>ISD = intra‐individual standard deviation</topic><topic>LDL = left dorsolateral</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>NF = non‐frontal</topic><topic>RDL = right dorsolateral</topic><topic>Reaction Time</topic><topic>Reproducibility of Results</topic><topic>RT = reaction time</topic><topic>SM = superior medial</topic><topic>Stroke - physiopathology</topic><topic>Stroke - psychology</topic><topic>TBI = traumatic brain injury</topic><topic>Traumas. Diseases due to physical agents</topic><topic>TSI = time since injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stuss, Donald T.</creatorcontrib><creatorcontrib>Murphy, Kelly J.</creatorcontrib><creatorcontrib>Binns, Malcolm A.</creatorcontrib><creatorcontrib>Alexander, Michael P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stuss, Donald T.</au><au>Murphy, Kelly J.</au><au>Binns, Malcolm A.</au><au>Alexander, Michael P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Staying on the job: the frontal lobes control individual performance variability</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>126</volume><issue>11</issue><spage>2363</spage><epage>2380</epage><pages>2363-2380</pages><issn>0006-8950</issn><issn>1460-2156</issn><eissn>1460-2156</eissn><coden>BRAIAK</coden><abstract>The causes of variability of performance by individual subjects have rarely been investigated, although excessive variability or inconsistency may be a functionally significant factor for many real‐life activities. Our objective was to determine whether patients with focal frontal brain lesions have excessive individual performance variability. Thirty‐six patients with focal frontal (n = 25) or non‐frontal (n = 11) lesions were compared with 12 control subjects on different measures of intra‐individual variability: dispersion within a testing session; and consistency across testing sessions. Four reaction time tasks, varying in levels of complexity and based on a model of detection using feature integration, were administered. Following the first test session, 22 patients and 10 controls returned for two subsequent test sessions, which permitted the assessment of consistency of performance. Measures of abnormal dispersion of performance on these tests were observed in frontal patients only (except those with exclusively inferior medial damage). Disturbances in consistency of performance were observed primarily in patients with frontal lesions. Damage to the frontal lobes impairs the stability of cognitive performance. Damage to different frontal regions causes different profiles of abnormal variability. Fluctuations in performance of a task may underlie some of the reported difficulties in daily tasks reported by patients with frontal injuries.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12876148</pmid><doi>10.1093/brain/awg237</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Attention Biological and medical sciences Brain Diseases - parasitology Brain Diseases - physiopathology Brain Diseases - psychology CTL = control Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DL = dorsolateral Female Frontal Lobe - injuries Frontal Lobe - pathology Frontal Lobe - physiopathology frontal lobes Humans ICV = intra‐individual coefficient of variation IIV = intra‐individual variability IM = inferior medial individual differences Injuries of the nervous system and the skull. Diseases due to physical agents intra‐individual variability ISD = intra‐individual standard deviation LDL = left dorsolateral Male Medical sciences Middle Aged Neurology Neuropsychological Tests NF = non‐frontal RDL = right dorsolateral Reaction Time Reproducibility of Results RT = reaction time SM = superior medial Stroke - physiopathology Stroke - psychology TBI = traumatic brain injury Traumas. Diseases due to physical agents TSI = time since injury |
| title | Staying on the job: the frontal lobes control individual performance variability |
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