Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis

Background/Aims : We explored the involvement of cell types, cytokines and lipid peroxidation in a rat dietary model of fibrosing steatohepatitis. Methods : Male rats were fed a high fat diet deficient in methionine and choline (MCD) for up to 17 weeks. Whole liver, hepatocytes and non-parenchymal c...

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Veröffentlicht in:	Journal of hepatology 2003-11, Vol.39 (5), p.756-764
Hauptverfasser:	George, Jacob, Pera, Natasha, Phung, Nghi, Leclercq, Isabelle, Yun Hou, Jing, Farrell, Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Choline - administration & dosage Collagen Diet Fatty Liver - complications Fatty Liver - etiology Fatty Liver - genetics Fatty Liver - physiopathology Gene Expression Hepatic fibrosis Hepatocytes Hepatocytes - metabolism Lipid Peroxidation Liver - pathology Liver - physiopathology Liver Cirrhosis - etiology Male Methionine - administration & dosage Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Steatohepatitis Stellate cells Transforming Growth Factor beta - genetics Transforming growth factor-beta Up-Regulation
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