Mice with a targeted disruption of the Fanconi anemia homolog Fanca

Fanconi anemia (FA) is a hereditary chromosomal instability syndrome with cancer predisposition. Bone marrow failure resulting in pancytopenia is the main cause of death of FA patients. Diagnosis of FA is based on their cellular hypersensitivity to DNA crosslinking agents and chromosome breakages. S...

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Veröffentlicht in:	Human molecular genetics 2000-07, Vol.9 (12), p.1805-1811
Hauptverfasser:	NGAN CHING CHENG, VAN DE VRUGT, H. J, VAN DER VALK, M. A, OOSTRA, A. B, KRIMPENFORT, P, DE VRIES, Y, JOENJE, H, BERNS, A, ARWERT, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemias. Hemoglobinopathies Animals Biological and medical sciences Diseases of red blood cells DNA-Binding Proteins Fanca gene Fanconi Anemia Fanconi Anemia Complementation Group A Protein Female Gene Targeting Hematologic and hematopoietic diseases Hematology Humans Infertility, Female Infertility, Male Male Medical sciences Mice Mice, Knockout mitomycin C Ovary - abnormalities Ovary - pathology Phenotype Proteins - genetics Proteins - physiology Testis - abnormalities Testis - pathology
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