Defective P2Y purinergic receptor function: A possible novel mechanism for impaired glucose transport

Extracellular ATP is an ubiquitous mediator that regulates several cellular functions via specific P2 plasma membrane receptors (P2Rs), for which a role in modulating intracellular glucose metabolism has been recently suggested. We have investigated glucose uptake in response to P2Rs stimulation in...

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Veröffentlicht in:	Journal of cellular physiology 2003-12, Vol.197 (3), p.435-444
Hauptverfasser:	Solini, Anna, Chiozzi, Paola, Morelli, Anna, Passaro, Angela, Fellin, Renato, Virgilio, Francesco Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Apyrase - metabolism Biological Transport - physiology Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Diabetes Mellitus, Type 2 - metabolism Energy Metabolism - physiology Extracellular Fluid - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Glucose - metabolism Glucose Transporter Type 1 Hexokinase - metabolism Humans Insulin Resistance - physiology Membrane Potentials - drug effects Membrane Potentials - physiology Monosaccharide Transport Proteins - metabolism Receptors, Purinergic P2 - genetics Receptors, Purinergic P2Y1 RNA, Messenger - metabolism
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