Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides

We have determined the crystal structure of an active, hexameric fragment of the gene 4 helicase from bacteriophage T7. The structure reveals how subunit contacts stabilize the hexamer. Deviation from expected six-fold symmetry of the hexamer indicates that the structure is of an intermediate on the...

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Veröffentlicht in:	Cell 2000-06, Vol.101 (6), p.589-600
Hauptverfasser:	Singleton, M R, Sawaya, M R, Ellenberger, T, Wigley, D B
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage T7 DNA helicase DNA Helicases - chemistry gene 4 protein Hydrolysis Nucleotides - chemistry Phage T7 Protein Conformation
Online-Zugang:	Volltext
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