Dietary β-Carotene Stimulates Cell-Mediated and Humoral Immune Response in Dogs
The role of β-carotene on immune response in domestic dogs is not known. Female Beagle dogs were fed 0, 2, 20 or 50 mg β-carotene/d; blood was sampled at wk 0, 1, 2, 4 and 8 for analysis of the following: lymphoproliferation, leukocyte subpopulations and concentrations of interleukin-2 (IL-2), immun...
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| Veröffentlicht in: | The Journal of nutrition 2000-08, Vol.130 (8), p.1910-1913 |
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| container_title | The Journal of nutrition |
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| creator | Chew, Boon P. Park, Jean Soon Wong, Teri S. Kim, Hong Wook Weng, Brian B.C. Byrne, Katherine M. Hayek, Michael G. Reinhart, Gregory A. |
| description | The role of β-carotene on immune response in domestic dogs is not known. Female Beagle dogs were fed 0, 2, 20 or 50 mg β-carotene/d; blood was sampled at wk 0, 1, 2, 4 and 8 for analysis of the following: lymphoproliferation, leukocyte subpopulations and concentrations of interleukin-2 (IL-2), immunoglobulin (Ig)G and IgM. Delayed-type hypersensitivity (DTH) response was assessed at wk 0, 3 and 7. β-Carotene supplementation increased plasma β-carotene concentrations in a dose-dependent manner. Compared with unsupplemented dogs, those fed 20 or 50 mg of β-carotene had higher CD4+ cell numbers and CD4:CD8 ratio. However, there was no treatment difference in CD8+, CD21+ and major histocompatability complex (MHC) class II+ cells. Plasma IgG, but not IgM concentration was higher in dogs fed β-carotene throughout the study period. The DTH response to phytohemagglutinin (PHA) and vaccine was heightened in β-carotene–supplemented dogs. β-Carotene feeding did not influence mitogen-induced lymphocyte proliferation or IL-2 production. Immune response was impaired in dogs classified as low β-carotene absorbers compared with similar dogs fed the same amount of β-carotene. Therefore, dietary β-carotene heightened cell-mediated and humoral immune responses in dogs. |
| doi_str_mv | 10.1093/jn/130.8.1910 |
| format | Article |
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Female Beagle dogs were fed 0, 2, 20 or 50 mg β-carotene/d; blood was sampled at wk 0, 1, 2, 4 and 8 for analysis of the following: lymphoproliferation, leukocyte subpopulations and concentrations of interleukin-2 (IL-2), immunoglobulin (Ig)G and IgM. Delayed-type hypersensitivity (DTH) response was assessed at wk 0, 3 and 7. β-Carotene supplementation increased plasma β-carotene concentrations in a dose-dependent manner. Compared with unsupplemented dogs, those fed 20 or 50 mg of β-carotene had higher CD4+ cell numbers and CD4:CD8 ratio. However, there was no treatment difference in CD8+, CD21+ and major histocompatability complex (MHC) class II+ cells. Plasma IgG, but not IgM concentration was higher in dogs fed β-carotene throughout the study period. The DTH response to phytohemagglutinin (PHA) and vaccine was heightened in β-carotene–supplemented dogs. β-Carotene feeding did not influence mitogen-induced lymphocyte proliferation or IL-2 production. Immune response was impaired in dogs classified as low β-carotene absorbers compared with similar dogs fed the same amount of β-carotene. Therefore, dietary β-carotene heightened cell-mediated and humoral immune responses in dogs.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/130.8.1910</identifier><identifier>PMID: 10917901</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Antibody Formation - drug effects ; Antioxidants - pharmacology ; beta Carotene - pharmacology ; Biological and medical sciences ; canines ; Chromatography, High Pressure Liquid ; Dogs - immunology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Hypersensitivity, Delayed - immunology ; immunity ; Immunity, Cellular - drug effects ; Immunoglobulin G - biosynthesis ; Interleukin-2 - biosynthesis ; Leukocytes - drug effects ; Leukocytes - immunology ; Lymphocyte Activation - drug effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; β-carotene</subject><ispartof>The Journal of nutrition, 2000-08, Vol.130 (8), p.1910-1913</ispartof><rights>2000 American Society for Nutrition.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-91db3c1448c4c287f07c9e11177e89d576db784cc632570d7f86dfb5594c61123</citedby><cites>FETCH-LOGICAL-c405t-91db3c1448c4c287f07c9e11177e89d576db784cc632570d7f86dfb5594c61123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1531875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10917901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chew, Boon P.</creatorcontrib><creatorcontrib>Park, Jean Soon</creatorcontrib><creatorcontrib>Wong, Teri S.</creatorcontrib><creatorcontrib>Kim, Hong Wook</creatorcontrib><creatorcontrib>Weng, Brian B.C.</creatorcontrib><creatorcontrib>Byrne, Katherine M.</creatorcontrib><creatorcontrib>Hayek, Michael G.</creatorcontrib><creatorcontrib>Reinhart, Gregory A.</creatorcontrib><title>Dietary β-Carotene Stimulates Cell-Mediated and Humoral Immune Response in Dogs</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The role of β-carotene on immune response in domestic dogs is not known. Female Beagle dogs were fed 0, 2, 20 or 50 mg β-carotene/d; blood was sampled at wk 0, 1, 2, 4 and 8 for analysis of the following: lymphoproliferation, leukocyte subpopulations and concentrations of interleukin-2 (IL-2), immunoglobulin (Ig)G and IgM. Delayed-type hypersensitivity (DTH) response was assessed at wk 0, 3 and 7. β-Carotene supplementation increased plasma β-carotene concentrations in a dose-dependent manner. Compared with unsupplemented dogs, those fed 20 or 50 mg of β-carotene had higher CD4+ cell numbers and CD4:CD8 ratio. However, there was no treatment difference in CD8+, CD21+ and major histocompatability complex (MHC) class II+ cells. Plasma IgG, but not IgM concentration was higher in dogs fed β-carotene throughout the study period. The DTH response to phytohemagglutinin (PHA) and vaccine was heightened in β-carotene–supplemented dogs. β-Carotene feeding did not influence mitogen-induced lymphocyte proliferation or IL-2 production. Immune response was impaired in dogs classified as low β-carotene absorbers compared with similar dogs fed the same amount of β-carotene. Therefore, dietary β-carotene heightened cell-mediated and humoral immune responses in dogs.</description><subject>Animals</subject><subject>Antibody Formation - drug effects</subject><subject>Antioxidants - pharmacology</subject><subject>beta Carotene - pharmacology</subject><subject>Biological and medical sciences</subject><subject>canines</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dogs - immunology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>immunity</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>β-carotene</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1qGzEQwHFRGmI3zbHXsofS2zoz-yXpWOymDiQkpMlZyNJskdnVutJuIa-VB8kzRcaG5NKTEPw0jP6MfUFYIMjyYusvsISFWKBE-MDmWFeYNwjwkc0BiiIvsWlm7FOMWwDASopTNksvkUvAObtbORp1eMpenvOlDsNInrLfo-unTo8UsyV1XX5D1qWbzbS32Xrqh6C77Krvp2TvKe4GHylzPlsNf-JndtLqLtL58Txjj5c_H5br_Pr219Xyx3VuKqjHXKLdlAarSpjKFIK3wI0kROSchLQ1b-yGi8qYpixqDpa3orHtpq5lZRrEojxj3w9zd2H4O1EcVe-iSdtqT8MUFcdCgIQywfwATRhiDNSqXXB9-rJCUPuEautVSqiE2idM_utx8LTpyb7Th2YJfDsCHY3u2qC9cfHN1SUKXifGD4xShX-OgorGkTepZSAzKju4_2zwCjQ7iso</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Chew, Boon P.</creator><creator>Park, Jean Soon</creator><creator>Wong, Teri S.</creator><creator>Kim, Hong Wook</creator><creator>Weng, Brian B.C.</creator><creator>Byrne, Katherine M.</creator><creator>Hayek, Michael G.</creator><creator>Reinhart, Gregory A.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>Dietary β-Carotene Stimulates Cell-Mediated and Humoral Immune Response in Dogs</title><author>Chew, Boon P. ; Park, Jean Soon ; Wong, Teri S. ; Kim, Hong Wook ; Weng, Brian B.C. ; Byrne, Katherine M. ; Hayek, Michael G. ; Reinhart, Gregory A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-91db3c1448c4c287f07c9e11177e89d576db784cc632570d7f86dfb5594c61123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antibody Formation - drug effects</topic><topic>Antioxidants - pharmacology</topic><topic>beta Carotene - pharmacology</topic><topic>Biological and medical sciences</topic><topic>canines</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dogs - immunology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>immunity</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - immunology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>β-carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chew, Boon P.</creatorcontrib><creatorcontrib>Park, Jean Soon</creatorcontrib><creatorcontrib>Wong, Teri S.</creatorcontrib><creatorcontrib>Kim, Hong Wook</creatorcontrib><creatorcontrib>Weng, Brian B.C.</creatorcontrib><creatorcontrib>Byrne, Katherine M.</creatorcontrib><creatorcontrib>Hayek, Michael G.</creatorcontrib><creatorcontrib>Reinhart, Gregory A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chew, Boon P.</au><au>Park, Jean Soon</au><au>Wong, Teri S.</au><au>Kim, Hong Wook</au><au>Weng, Brian B.C.</au><au>Byrne, Katherine M.</au><au>Hayek, Michael G.</au><au>Reinhart, Gregory A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary β-Carotene Stimulates Cell-Mediated and Humoral Immune Response in Dogs</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>130</volume><issue>8</issue><spage>1910</spage><epage>1913</epage><pages>1910-1913</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The role of β-carotene on immune response in domestic dogs is not known. Female Beagle dogs were fed 0, 2, 20 or 50 mg β-carotene/d; blood was sampled at wk 0, 1, 2, 4 and 8 for analysis of the following: lymphoproliferation, leukocyte subpopulations and concentrations of interleukin-2 (IL-2), immunoglobulin (Ig)G and IgM. Delayed-type hypersensitivity (DTH) response was assessed at wk 0, 3 and 7. β-Carotene supplementation increased plasma β-carotene concentrations in a dose-dependent manner. Compared with unsupplemented dogs, those fed 20 or 50 mg of β-carotene had higher CD4+ cell numbers and CD4:CD8 ratio. However, there was no treatment difference in CD8+, CD21+ and major histocompatability complex (MHC) class II+ cells. Plasma IgG, but not IgM concentration was higher in dogs fed β-carotene throughout the study period. The DTH response to phytohemagglutinin (PHA) and vaccine was heightened in β-carotene–supplemented dogs. β-Carotene feeding did not influence mitogen-induced lymphocyte proliferation or IL-2 production. Immune response was impaired in dogs classified as low β-carotene absorbers compared with similar dogs fed the same amount of β-carotene. Therefore, dietary β-carotene heightened cell-mediated and humoral immune responses in dogs.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>10917901</pmid><doi>10.1093/jn/130.8.1910</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibody Formation - drug effects Antioxidants - pharmacology beta Carotene - pharmacology Biological and medical sciences canines Chromatography, High Pressure Liquid Dogs - immunology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Hypersensitivity, Delayed - immunology immunity Immunity, Cellular - drug effects Immunoglobulin G - biosynthesis Interleukin-2 - biosynthesis Leukocytes - drug effects Leukocytes - immunology Lymphocyte Activation - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems β-carotene |
| title | Dietary β-Carotene Stimulates Cell-Mediated and Humoral Immune Response in Dogs |
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