Inhibition of mitogen-activated protein kinase kinase blocks proliferation of neural progenitor cells

Nestin-expressing neural progenitor (NP) cells have been isolated from the subventricular zone (SVZ) of the brain and propagated with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). In other neural cell types it has been shown that EGF and bFGF activate cell surface receptor...

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Veröffentlicht in:	Brain research. Developmental brain research 2000-07, Vol.122 (1), p.97-109
Hauptverfasser:	Learish, Randall D, Bruss, Matthew D, Haak-Frendscho, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Astrocytes - cytology Astrocytes - enzymology Basic fibroblast growth factor Butadienes - pharmacology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Division - drug effects Cell Division - physiology Cells, Cultured Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Epidermal growth factor Epidermal Growth Factor - pharmacology Female Fetus - cytology Fibroblast Growth Factor 2 - pharmacology Flavonoids - pharmacology In Situ Nick-End Labeling Intermediate Filament Proteins - biosynthesis MAP Kinase Kinase 1 MEK1 Mitogen-activated protein kinase Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Nerve Tissue Proteins Nestin Neural progenitor Neurons - cytology Neurons - enzymology Nitriles - pharmacology Oligodendroglia - cytology Oligodendroglia - enzymology Phosphorylation Pregnancy Proliferation Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Rats Rats, Sprague-Dawley Stem Cells - cytology Stem Cells - enzymology
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