Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies

We have previously demonstrated that blockade of either CD80/86-CD28 or CD40-CD154 costimulatory pathways by using adenovirus vector coding CTLA4Ig (AdCTLA4Ig) or CD40Ig (AdCD40Ig) genes induced donor-specific tolerance in rat liver transplantation. In this study, we asked whether these gene-therapy...

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Veröffentlicht in:	Transplantation 2003-10, Vol.76 (7), p.1089-1096
Hauptverfasser:	YAMASHITA, Kenichiro, MASUNAGA, Taro, FURUKAWA, Hiroyuki, UEDE, Toshimistu, TODO, Satoru, YANAGIDA, Naoyuki, TAKEHARA, Megumi, HASHIMOTO, Taku, KOBAYASHI, Tokushi, ECHIZENYA, Hayato, HUA, Nan, FUJITA, Miri, MURAKAMI, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Adenoviridae - genetics Animals Biological and medical sciences Cell Division Combined surgery. Multiple transplantations Gene Expression Genetic Therapy Genetic Vectors Graft Survival Heart Transplantation Immunoconjugates - blood Immunoconjugates - genetics Lymph Nodes - pathology Lymphocytes - pathology Male Medical sciences Myocardium - pathology Postoperative Period Rats Rats, Inbred ACI Rats, Inbred BN Rats, Inbred Lew Skin Transplantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes, Cytotoxic - pathology Transgenes Transplantation, Homologous Treatment Outcome
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