Diagnosis and management of fetal cardiac anomalies: 10 years of experience at a single institution
Objective To assess the diagnostic accuracy of fetal echocardiography and the outcome of cardiac malformations diagnosed in utero. Design A retrospective study. Methods The archives of our ultrasound laboratory were searched for fetal cardiac abnormalities in the period 1991–2001. Results Diagnosis...
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| Veröffentlicht in: | Ultrasound in obstetrics & gynecology 2001-12, Vol.18 (6), p.615-618 |
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| creator | Perolo, A. Prandstraller, D. Ghi, T. Gargiulo, G. Leone, O. Bovicelli, L. Pilu, G. |
| description | Objective
To assess the diagnostic accuracy of fetal echocardiography and the outcome of cardiac malformations diagnosed in utero.
Design
A retrospective study.
Methods
The archives of our ultrasound laboratory were searched for fetal cardiac abnormalities in the period 1991–2001.
Results
Diagnosis of a fetal cardiac anomaly was made in 339 pregnancies at a mean gestational age of 26.2 weeks. Pathology or a detailed postnatal follow‐up was available in 260 cases, and the prenatal diagnosis was accurate in 236 cases (91%). Discrepancies included nine false positive diagnoses (six ventricular septal defects and three coarctation of the aorta) and 15 cases in which a cardiac anomaly different from the one suspected in utero was documented. Of the 142 fetuses with isolated cardiac malformations (no extracardiac anomalies, normal chromosomes) that were delivered in our center, 114 were alive (80.2%) at a mean follow‐up of 38 months (range, 1–120 months). In this group of patients, conotruncal anomalies and univentricular lesions were the most frequent types of anomaly, and had a survival rate of 87% and 57%, respectively. Hypoplastic left heart was the most frequent isolated congenital heart defect in infants that were delivered (19 cases) and it was associated with a survival rate of 37%.
Conclusion
In expert hands, fetal echocardiography is highly accurate. The long‐term prognosis of cardiac lesions diagnosed in utero is similar to that reported in series of infants diagnosed after birth. The only exception is hypoplastic left heart in which the survival rate is much lower than expected from postnatal studies.Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecology |
| doi_str_mv | 10.1046/j.0960-7692.2001.00586.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71277380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71277380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4690-948eb1cd34d043500b213653b65e1a7e10bfa952453080a667270abb48d8663d3</originalsourceid><addsrcrecordid>eNqNkD1v2zAQhomgRey4-QsBl3aTchQpSiq6FGk-CgTIUs_EiToZNCTKIWXU_veVYiNZO93A5-W99zDGBaQClL7dplBpSApdZWkGIFKAvNTp4YIthdJVAgXkn9jyHVqwqxi3AKCV1JdsIUSp1BRcMvvL4cYP0UWOvuE9etxQT37kQ8tbGrHjFkPj0E7vQ4-do_h96sGPhCHOEB12FBx5SxxHjjw6v-mIOx9HN-5HN_gv7HOLXaTr81yx9cP9n7un5Pnl8ffdz-fETp0hqVRJtbCNVA0omQPUmZA6l7XOSWBBAuoWqzxTuYQSUOsiKwDrWpVNqbVs5Ip9O_27C8PrnuJoehctdR16GvbRFCIrClnCBJYn0IYhxkCt2QXXYzgaAWYWbLZmdmdmd2YWbN4Em8MUvTnv2Nc9NR_Bs9EJ-HoGMFrs2oDeuvjBKZFrPR22Yj9O3F_X0fG_C5j1y6PQIP8BqdaVKg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71277380</pqid></control><display><type>article</type><title>Diagnosis and management of fetal cardiac anomalies: 10 years of experience at a single institution</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Perolo, A. ; Prandstraller, D. ; Ghi, T. ; Gargiulo, G. ; Leone, O. ; Bovicelli, L. ; Pilu, G.</creator><creatorcontrib>Perolo, A. ; Prandstraller, D. ; Ghi, T. ; Gargiulo, G. ; Leone, O. ; Bovicelli, L. ; Pilu, G.</creatorcontrib><description>Objective
To assess the diagnostic accuracy of fetal echocardiography and the outcome of cardiac malformations diagnosed in utero.
Design
A retrospective study.
Methods
The archives of our ultrasound laboratory were searched for fetal cardiac abnormalities in the period 1991–2001.
Results
Diagnosis of a fetal cardiac anomaly was made in 339 pregnancies at a mean gestational age of 26.2 weeks. Pathology or a detailed postnatal follow‐up was available in 260 cases, and the prenatal diagnosis was accurate in 236 cases (91%). Discrepancies included nine false positive diagnoses (six ventricular septal defects and three coarctation of the aorta) and 15 cases in which a cardiac anomaly different from the one suspected in utero was documented. Of the 142 fetuses with isolated cardiac malformations (no extracardiac anomalies, normal chromosomes) that were delivered in our center, 114 were alive (80.2%) at a mean follow‐up of 38 months (range, 1–120 months). In this group of patients, conotruncal anomalies and univentricular lesions were the most frequent types of anomaly, and had a survival rate of 87% and 57%, respectively. Hypoplastic left heart was the most frequent isolated congenital heart defect in infants that were delivered (19 cases) and it was associated with a survival rate of 37%.
Conclusion
In expert hands, fetal echocardiography is highly accurate. The long‐term prognosis of cardiac lesions diagnosed in utero is similar to that reported in series of infants diagnosed after birth. The only exception is hypoplastic left heart in which the survival rate is much lower than expected from postnatal studies.Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecology</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1046/j.0960-7692.2001.00586.x</identifier><identifier>PMID: 11844200</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Congenital anomalies ; Congenital heart disease ; Echocardiography ; Female ; Fetal Heart - diagnostic imaging ; Fetus ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Heart Defects, Congenital - diagnostic imaging ; Heart Defects, Congenital - mortality ; Heart Defects, Congenital - therapy ; Humans ; Hypoplastic Left Heart Syndrome - diagnostic imaging ; Hypoplastic Left Heart Syndrome - mortality ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prenatal diagnosis ; Retrospective Studies ; Survival Rate ; Ultrasonography, Prenatal ; Ultrasound</subject><ispartof>Ultrasound in obstetrics & gynecology, 2001-12, Vol.18 (6), p.615-618</ispartof><rights>Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecology</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4690-948eb1cd34d043500b213653b65e1a7e10bfa952453080a667270abb48d8663d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.0960-7692.2001.00586.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.0960-7692.2001.00586.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14156621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11844200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perolo, A.</creatorcontrib><creatorcontrib>Prandstraller, D.</creatorcontrib><creatorcontrib>Ghi, T.</creatorcontrib><creatorcontrib>Gargiulo, G.</creatorcontrib><creatorcontrib>Leone, O.</creatorcontrib><creatorcontrib>Bovicelli, L.</creatorcontrib><creatorcontrib>Pilu, G.</creatorcontrib><title>Diagnosis and management of fetal cardiac anomalies: 10 years of experience at a single institution</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objective
To assess the diagnostic accuracy of fetal echocardiography and the outcome of cardiac malformations diagnosed in utero.
Design
A retrospective study.
Methods
The archives of our ultrasound laboratory were searched for fetal cardiac abnormalities in the period 1991–2001.
Results
Diagnosis of a fetal cardiac anomaly was made in 339 pregnancies at a mean gestational age of 26.2 weeks. Pathology or a detailed postnatal follow‐up was available in 260 cases, and the prenatal diagnosis was accurate in 236 cases (91%). Discrepancies included nine false positive diagnoses (six ventricular septal defects and three coarctation of the aorta) and 15 cases in which a cardiac anomaly different from the one suspected in utero was documented. Of the 142 fetuses with isolated cardiac malformations (no extracardiac anomalies, normal chromosomes) that were delivered in our center, 114 were alive (80.2%) at a mean follow‐up of 38 months (range, 1–120 months). In this group of patients, conotruncal anomalies and univentricular lesions were the most frequent types of anomaly, and had a survival rate of 87% and 57%, respectively. Hypoplastic left heart was the most frequent isolated congenital heart defect in infants that were delivered (19 cases) and it was associated with a survival rate of 37%.
Conclusion
In expert hands, fetal echocardiography is highly accurate. The long‐term prognosis of cardiac lesions diagnosed in utero is similar to that reported in series of infants diagnosed after birth. The only exception is hypoplastic left heart in which the survival rate is much lower than expected from postnatal studies.Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecology</description><subject>Biological and medical sciences</subject><subject>Congenital anomalies</subject><subject>Congenital heart disease</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Fetal Heart - diagnostic imaging</subject><subject>Fetus</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart Defects, Congenital - diagnostic imaging</subject><subject>Heart Defects, Congenital - mortality</subject><subject>Heart Defects, Congenital - therapy</subject><subject>Humans</subject><subject>Hypoplastic Left Heart Syndrome - diagnostic imaging</subject><subject>Hypoplastic Left Heart Syndrome - mortality</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal diagnosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Ultrasonography, Prenatal</subject><subject>Ultrasound</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1v2zAQhomgRey4-QsBl3aTchQpSiq6FGk-CgTIUs_EiToZNCTKIWXU_veVYiNZO93A5-W99zDGBaQClL7dplBpSApdZWkGIFKAvNTp4YIthdJVAgXkn9jyHVqwqxi3AKCV1JdsIUSp1BRcMvvL4cYP0UWOvuE9etxQT37kQ8tbGrHjFkPj0E7vQ4-do_h96sGPhCHOEB12FBx5SxxHjjw6v-mIOx9HN-5HN_gv7HOLXaTr81yx9cP9n7un5Pnl8ffdz-fETp0hqVRJtbCNVA0omQPUmZA6l7XOSWBBAuoWqzxTuYQSUOsiKwDrWpVNqbVs5Ip9O_27C8PrnuJoehctdR16GvbRFCIrClnCBJYn0IYhxkCt2QXXYzgaAWYWbLZmdmdmd2YWbN4Em8MUvTnv2Nc9NR_Bs9EJ-HoGMFrs2oDeuvjBKZFrPR22Yj9O3F_X0fG_C5j1y6PQIP8BqdaVKg</recordid><startdate>200112</startdate><enddate>200112</enddate><creator>Perolo, A.</creator><creator>Prandstraller, D.</creator><creator>Ghi, T.</creator><creator>Gargiulo, G.</creator><creator>Leone, O.</creator><creator>Bovicelli, L.</creator><creator>Pilu, G.</creator><general>Blackwell Science Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200112</creationdate><title>Diagnosis and management of fetal cardiac anomalies: 10 years of experience at a single institution</title><author>Perolo, A. ; Prandstraller, D. ; Ghi, T. ; Gargiulo, G. ; Leone, O. ; Bovicelli, L. ; Pilu, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4690-948eb1cd34d043500b213653b65e1a7e10bfa952453080a667270abb48d8663d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Congenital anomalies</topic><topic>Congenital heart disease</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Fetal Heart - diagnostic imaging</topic><topic>Fetus</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heart Defects, Congenital - diagnostic imaging</topic><topic>Heart Defects, Congenital - mortality</topic><topic>Heart Defects, Congenital - therapy</topic><topic>Humans</topic><topic>Hypoplastic Left Heart Syndrome - diagnostic imaging</topic><topic>Hypoplastic Left Heart Syndrome - mortality</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal diagnosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Ultrasonography, Prenatal</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perolo, A.</creatorcontrib><creatorcontrib>Prandstraller, D.</creatorcontrib><creatorcontrib>Ghi, T.</creatorcontrib><creatorcontrib>Gargiulo, G.</creatorcontrib><creatorcontrib>Leone, O.</creatorcontrib><creatorcontrib>Bovicelli, L.</creatorcontrib><creatorcontrib>Pilu, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perolo, A.</au><au>Prandstraller, D.</au><au>Ghi, T.</au><au>Gargiulo, G.</au><au>Leone, O.</au><au>Bovicelli, L.</au><au>Pilu, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis and management of fetal cardiac anomalies: 10 years of experience at a single institution</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2001-12</date><risdate>2001</risdate><volume>18</volume><issue>6</issue><spage>615</spage><epage>618</epage><pages>615-618</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><abstract>Objective
To assess the diagnostic accuracy of fetal echocardiography and the outcome of cardiac malformations diagnosed in utero.
Design
A retrospective study.
Methods
The archives of our ultrasound laboratory were searched for fetal cardiac abnormalities in the period 1991–2001.
Results
Diagnosis of a fetal cardiac anomaly was made in 339 pregnancies at a mean gestational age of 26.2 weeks. Pathology or a detailed postnatal follow‐up was available in 260 cases, and the prenatal diagnosis was accurate in 236 cases (91%). Discrepancies included nine false positive diagnoses (six ventricular septal defects and three coarctation of the aorta) and 15 cases in which a cardiac anomaly different from the one suspected in utero was documented. Of the 142 fetuses with isolated cardiac malformations (no extracardiac anomalies, normal chromosomes) that were delivered in our center, 114 were alive (80.2%) at a mean follow‐up of 38 months (range, 1–120 months). In this group of patients, conotruncal anomalies and univentricular lesions were the most frequent types of anomaly, and had a survival rate of 87% and 57%, respectively. Hypoplastic left heart was the most frequent isolated congenital heart defect in infants that were delivered (19 cases) and it was associated with a survival rate of 37%.
Conclusion
In expert hands, fetal echocardiography is highly accurate. The long‐term prognosis of cardiac lesions diagnosed in utero is similar to that reported in series of infants diagnosed after birth. The only exception is hypoplastic left heart in which the survival rate is much lower than expected from postnatal studies.Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecology</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11844200</pmid><doi>10.1046/j.0960-7692.2001.00586.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-7692 |
| ispartof | Ultrasound in obstetrics & gynecology, 2001-12, Vol.18 (6), p.615-618 |
| issn | 0960-7692 1469-0705 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Wiley Online Library (Open Access Collection) |
| subjects | Biological and medical sciences Congenital anomalies Congenital heart disease Echocardiography Female Fetal Heart - diagnostic imaging Fetus Gestational Age Gynecology. Andrology. Obstetrics Heart Defects, Congenital - diagnostic imaging Heart Defects, Congenital - mortality Heart Defects, Congenital - therapy Humans Hypoplastic Left Heart Syndrome - diagnostic imaging Hypoplastic Left Heart Syndrome - mortality Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy. Fetus. Placenta Prenatal diagnosis Retrospective Studies Survival Rate Ultrasonography, Prenatal Ultrasound |
| title | Diagnosis and management of fetal cardiac anomalies: 10 years of experience at a single institution |
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