Reduced synthesis of inflammatory cytokines by a free radical scavenger after hemorrhagic shock in rats

OBJECTIVESIntestinal ischemia/reperfusion during hemorrhage and resuscitation may be a major trigger for cytokine expression. To assess whether free radicals produced on tissue reperfusion may play a role in the inflammatory response after hemorrhage, we tested the effect of a free radical scavenger...

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Veröffentlicht in:	Critical care medicine 2000-07, Vol.28 (7), p.2522-2527
Hauptverfasser:	Tamion, Fabienne, Richard, Vincent, Bonmarchand, Guy, Leroy, Jacky, Hiron, Martine, Daveau, Maryvonne, Thuillez, Christian, Lebreton, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antioxidants - pharmacology Biological and medical sciences Blood Transfusion, Autologous Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Enzyme-Linked Immunosorbent Assay Free Radical Scavengers - pharmacology Glycine - analogs & derivatives Glycine - pharmacology Intensive care medicine Interleukin-6 - biosynthesis Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Medical sciences Rats Rats, Wistar Resuscitation - methods Reverse Transcriptase Polymerase Chain Reaction RNA, Complementary - isolation & purification Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - therapy Sulfhydryl Compounds - pharmacology Tumor Necrosis Factor-alpha - biosynthesis
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