The T cell activation molecule H4 and the CD28‐like molecule ICOS are identical

The recently cloned CD28‐like molecule ICOS displays striking similarities with H4, characterized some years ago in the mouse and recently in humans. Both molecules are selectively expressed by activated and germinal center T cells, display similar structure, and display co‐stimulatory activities. H...

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Veröffentlicht in:	European journal of immunology 2000-12, Vol.30 (12), p.3463-3467
Hauptverfasser:	Buonfiglio, Donatella, Bragardo, Manuela, Redoglia, Valter, Vaschetto, Rosanna, Bottarel, Flavia, Bonissoni, Sara, Bensi, Thea, Mezzatesta, Caterina, Janeway jr, Charles A., Dianzani, Umberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antigens, Differentiation, T-Lymphocyte - analysis Antigens, Differentiation, T-Lymphocyte - physiology CD28 CD28 antigen Cell Line CTLA‐4 Humans ICOS ICOS protein Immunodominant Epitopes - analysis Immunodominant Epitopes - physiology Inducible T-Cell Co-Stimulator Protein Mice Precipitin Tests Protozoan Proteins T cell co‐stimulation T-Lymphocytes - chemistry
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