Impact of vaccinations and infectious diseases on the risk of melanoma—evaluation of an EORTC case–control study
A significant correlation between a reduced risk of melanoma and BCG and vaccinia vaccination in early childhood or infectious diseases later in life has already been reported from the FEBrile Infections and Melanoma (FEBIM) multicentre case–control study. This correlation is further evaluated in th...
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| Veröffentlicht in: | European journal of cancer (1990) 2003-11, Vol.39 (16), p.2372-2378 |
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| creator | Krone, B. Kölmel, K.F. Grange, J.M. Mastrangelo, G. Henz, B.M. Botev, I.N. Niin, M. Seebacher, C. Lambert, D. Shafir, R. Kokoschka, E.-M. Kleeberg, U.R. Gefeller, O. Pfahlberg, A. |
| description | A significant correlation between a reduced risk of melanoma and BCG and vaccinia vaccination in early childhood or infectious diseases later in life has already been reported from the FEBrile Infections and Melanoma (FEBIM) multicentre case–control study. This correlation is further evaluated in this study based on 603 incident cases of malignant melanoma and 627 population controls in six European countries and Israel by means of a joint analysis of the influence of vaccinations and infectious diseases. In addition, the previously unconsidered impact of influenza vaccinations is evaluated for the whole study population. The strong effects of the frequently given BCG and vaccinia vaccinations in early childhood, as well as of uncommon previous severe infectious diseases, were apparently not cumulative. With the Odds Ratio (OR) being set at 1 in the absence of vaccinations and infectious diseases, the OR dropped to 0.37 (95% Confidence Interval (CI): 0.10–1.42) when subjects had experienced one or more severe infectious diseases, associated with a fever of > 38.5 °C, and had not been vaccinated with BCG or vaccinia. The OR was 0.29 (CI: 0.15–0.57) in those who had had a severe infectious disease and were vaccinated with either BCG or vaccinia and 0.33 (CI: 0.17–0.65) for those with 1 or more severe infectious diseases and who had received both vaccinations. We conclude that both vaccinations as well as previous episodes of having a severe infectious disease induced the same protective mechanism with regards to the risk of melanoma. Because of a ‘masking effect’ by the vaccinia vaccination, the protective effect of the BCG vaccination and of certain infectious diseases against cancer has remained undetected. The vaccinations contributed more to the protection of the population than a previous episode of having an infectious disease. In view of the termination of vaccinations with vaccinia in all countries and of BCG in many of them, these findings call for a re-evaluation of vaccination strategies. |
| doi_str_mv | 10.1016/S0959-8049(03)00625-7 |
| format | Article |
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This correlation is further evaluated in this study based on 603 incident cases of malignant melanoma and 627 population controls in six European countries and Israel by means of a joint analysis of the influence of vaccinations and infectious diseases. In addition, the previously unconsidered impact of influenza vaccinations is evaluated for the whole study population. The strong effects of the frequently given BCG and vaccinia vaccinations in early childhood, as well as of uncommon previous severe infectious diseases, were apparently not cumulative. With the Odds Ratio (OR) being set at 1 in the absence of vaccinations and infectious diseases, the OR dropped to 0.37 (95% Confidence Interval (CI): 0.10–1.42) when subjects had experienced one or more severe infectious diseases, associated with a fever of > 38.5 °C, and had not been vaccinated with BCG or vaccinia. The OR was 0.29 (CI: 0.15–0.57) in those who had had a severe infectious disease and were vaccinated with either BCG or vaccinia and 0.33 (CI: 0.17–0.65) for those with 1 or more severe infectious diseases and who had received both vaccinations. We conclude that both vaccinations as well as previous episodes of having a severe infectious disease induced the same protective mechanism with regards to the risk of melanoma. Because of a ‘masking effect’ by the vaccinia vaccination, the protective effect of the BCG vaccination and of certain infectious diseases against cancer has remained undetected. The vaccinations contributed more to the protection of the population than a previous episode of having an infectious disease. In view of the termination of vaccinations with vaccinia in all countries and of BCG in many of them, these findings call for a re-evaluation of vaccination strategies.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/S0959-8049(03)00625-7</identifier><identifier>PMID: 14556930</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Anticancer defence ; BCG ; BCG Vaccine ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Infection ; Infection - complications ; Influenza Vaccines ; Innate immunity ; Logistic Models ; Male ; Medical sciences ; Melanoma ; Melanoma - microbiology ; Melanoma - prevention & control ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Odds Ratio ; Risk Factors ; Skin Neoplasms - microbiology ; Skin Neoplasms - prevention & control ; Tumors ; Vaccination ; Vaccinia ; Vaccinia - complications</subject><ispartof>European journal of cancer (1990), 2003-11, Vol.39 (16), p.2372-2378</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-76ce15057445d0cbc6c72f56c12e679604bbe2ace01852708fb8fa9c8d3d32db3</citedby><cites>FETCH-LOGICAL-c443t-76ce15057445d0cbc6c72f56c12e679604bbe2ace01852708fb8fa9c8d3d32db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959804903006257$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15192900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14556930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krone, B.</creatorcontrib><creatorcontrib>Kölmel, K.F.</creatorcontrib><creatorcontrib>Grange, J.M.</creatorcontrib><creatorcontrib>Mastrangelo, G.</creatorcontrib><creatorcontrib>Henz, B.M.</creatorcontrib><creatorcontrib>Botev, I.N.</creatorcontrib><creatorcontrib>Niin, M.</creatorcontrib><creatorcontrib>Seebacher, C.</creatorcontrib><creatorcontrib>Lambert, D.</creatorcontrib><creatorcontrib>Shafir, R.</creatorcontrib><creatorcontrib>Kokoschka, E.-M.</creatorcontrib><creatorcontrib>Kleeberg, U.R.</creatorcontrib><creatorcontrib>Gefeller, O.</creatorcontrib><creatorcontrib>Pfahlberg, A.</creatorcontrib><title>Impact of vaccinations and infectious diseases on the risk of melanoma—evaluation of an EORTC case–control study</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>A significant correlation between a reduced risk of melanoma and BCG and vaccinia vaccination in early childhood or infectious diseases later in life has already been reported from the FEBrile Infections and Melanoma (FEBIM) multicentre case–control study. This correlation is further evaluated in this study based on 603 incident cases of malignant melanoma and 627 population controls in six European countries and Israel by means of a joint analysis of the influence of vaccinations and infectious diseases. In addition, the previously unconsidered impact of influenza vaccinations is evaluated for the whole study population. The strong effects of the frequently given BCG and vaccinia vaccinations in early childhood, as well as of uncommon previous severe infectious diseases, were apparently not cumulative. With the Odds Ratio (OR) being set at 1 in the absence of vaccinations and infectious diseases, the OR dropped to 0.37 (95% Confidence Interval (CI): 0.10–1.42) when subjects had experienced one or more severe infectious diseases, associated with a fever of > 38.5 °C, and had not been vaccinated with BCG or vaccinia. The OR was 0.29 (CI: 0.15–0.57) in those who had had a severe infectious disease and were vaccinated with either BCG or vaccinia and 0.33 (CI: 0.17–0.65) for those with 1 or more severe infectious diseases and who had received both vaccinations. We conclude that both vaccinations as well as previous episodes of having a severe infectious disease induced the same protective mechanism with regards to the risk of melanoma. Because of a ‘masking effect’ by the vaccinia vaccination, the protective effect of the BCG vaccination and of certain infectious diseases against cancer has remained undetected. The vaccinations contributed more to the protection of the population than a previous episode of having an infectious disease. In view of the termination of vaccinations with vaccinia in all countries and of BCG in many of them, these findings call for a re-evaluation of vaccination strategies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anticancer defence</subject><subject>BCG</subject><subject>BCG Vaccine</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infection</subject><subject>Infection - complications</subject><subject>Influenza Vaccines</subject><subject>Innate immunity</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma</subject><subject>Melanoma - microbiology</subject><subject>Melanoma - prevention & control</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Skin Neoplasms - microbiology</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Tumors</subject><subject>Vaccination</subject><subject>Vaccinia</subject><subject>Vaccinia - complications</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EokvhEUC-UMEhZZzEcXJCaNWWSpUqQTlbzngiDIm92MlKvfUd6BP2SZrsruiRkzXy99sz3zD2VsCpAFF9-g6NbLIayuYDFB8Bqlxm6hlbiVo1GdQyf85W_5Aj9iqlXwCg6hJesiNRSlk1BazYeDlsDI48dHxrEJ03ows-ceMtd74jnMspcesSmUSJB8_Hn8SjS7-XzEC98WEwD3f3tDX9tEsvF8bzs-tvN2uOc-zh7i8GP8bQ8zRO9vY1e9GZPtGbw3nMfpyf3ay_ZlfXF5frL1cZlmUxZqpCEhKkKktpAVusUOWdrFDkVKmmgrJtKTdIIOZ5FdRdW3emwdoWtshtWxyzk_27mxj-TJRGPbiE1M890zyVViJXRV2rGZR7EGNIKVKnN9ENJt5qAXrRrXe69eJSQ6F3uvWSe3f4YGoHsk-pg98ZeH8ATELTd9F4dOmJk6LJG1i4z3uOZh1bR1EndOSRrIvzDrQN7j-tPAILzJ-A</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Krone, B.</creator><creator>Kölmel, K.F.</creator><creator>Grange, J.M.</creator><creator>Mastrangelo, G.</creator><creator>Henz, B.M.</creator><creator>Botev, I.N.</creator><creator>Niin, M.</creator><creator>Seebacher, C.</creator><creator>Lambert, D.</creator><creator>Shafir, R.</creator><creator>Kokoschka, E.-M.</creator><creator>Kleeberg, U.R.</creator><creator>Gefeller, O.</creator><creator>Pfahlberg, A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Impact of vaccinations and infectious diseases on the risk of melanoma—evaluation of an EORTC case–control study</title><author>Krone, B. ; Kölmel, K.F. ; Grange, J.M. ; Mastrangelo, G. ; Henz, B.M. ; Botev, I.N. ; Niin, M. ; Seebacher, C. ; Lambert, D. ; Shafir, R. ; Kokoschka, E.-M. ; Kleeberg, U.R. ; Gefeller, O. ; Pfahlberg, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-76ce15057445d0cbc6c72f56c12e679604bbe2ace01852708fb8fa9c8d3d32db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anticancer defence</topic><topic>BCG</topic><topic>BCG Vaccine</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infection</topic><topic>Infection - complications</topic><topic>Influenza Vaccines</topic><topic>Innate immunity</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma</topic><topic>Melanoma - microbiology</topic><topic>Melanoma - prevention & control</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Skin Neoplasms - microbiology</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Tumors</topic><topic>Vaccination</topic><topic>Vaccinia</topic><topic>Vaccinia - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krone, B.</creatorcontrib><creatorcontrib>Kölmel, K.F.</creatorcontrib><creatorcontrib>Grange, J.M.</creatorcontrib><creatorcontrib>Mastrangelo, G.</creatorcontrib><creatorcontrib>Henz, B.M.</creatorcontrib><creatorcontrib>Botev, I.N.</creatorcontrib><creatorcontrib>Niin, M.</creatorcontrib><creatorcontrib>Seebacher, C.</creatorcontrib><creatorcontrib>Lambert, D.</creatorcontrib><creatorcontrib>Shafir, R.</creatorcontrib><creatorcontrib>Kokoschka, E.-M.</creatorcontrib><creatorcontrib>Kleeberg, U.R.</creatorcontrib><creatorcontrib>Gefeller, O.</creatorcontrib><creatorcontrib>Pfahlberg, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krone, B.</au><au>Kölmel, K.F.</au><au>Grange, J.M.</au><au>Mastrangelo, G.</au><au>Henz, B.M.</au><au>Botev, I.N.</au><au>Niin, M.</au><au>Seebacher, C.</au><au>Lambert, D.</au><au>Shafir, R.</au><au>Kokoschka, E.-M.</au><au>Kleeberg, U.R.</au><au>Gefeller, O.</au><au>Pfahlberg, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of vaccinations and infectious diseases on the risk of melanoma—evaluation of an EORTC case–control study</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>39</volume><issue>16</issue><spage>2372</spage><epage>2378</epage><pages>2372-2378</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>A significant correlation between a reduced risk of melanoma and BCG and vaccinia vaccination in early childhood or infectious diseases later in life has already been reported from the FEBrile Infections and Melanoma (FEBIM) multicentre case–control study. This correlation is further evaluated in this study based on 603 incident cases of malignant melanoma and 627 population controls in six European countries and Israel by means of a joint analysis of the influence of vaccinations and infectious diseases. In addition, the previously unconsidered impact of influenza vaccinations is evaluated for the whole study population. The strong effects of the frequently given BCG and vaccinia vaccinations in early childhood, as well as of uncommon previous severe infectious diseases, were apparently not cumulative. With the Odds Ratio (OR) being set at 1 in the absence of vaccinations and infectious diseases, the OR dropped to 0.37 (95% Confidence Interval (CI): 0.10–1.42) when subjects had experienced one or more severe infectious diseases, associated with a fever of > 38.5 °C, and had not been vaccinated with BCG or vaccinia. The OR was 0.29 (CI: 0.15–0.57) in those who had had a severe infectious disease and were vaccinated with either BCG or vaccinia and 0.33 (CI: 0.17–0.65) for those with 1 or more severe infectious diseases and who had received both vaccinations. We conclude that both vaccinations as well as previous episodes of having a severe infectious disease induced the same protective mechanism with regards to the risk of melanoma. Because of a ‘masking effect’ by the vaccinia vaccination, the protective effect of the BCG vaccination and of certain infectious diseases against cancer has remained undetected. The vaccinations contributed more to the protection of the population than a previous episode of having an infectious disease. In view of the termination of vaccinations with vaccinia in all countries and of BCG in many of them, these findings call for a re-evaluation of vaccination strategies.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>14556930</pmid><doi>10.1016/S0959-8049(03)00625-7</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 2003-11, Vol.39 (16), p.2372-2378 |
| issn | 0959-8049 1879-0852 |
| language | eng |
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| subjects | Adolescent Adult Aged Anticancer defence BCG BCG Vaccine Biological and medical sciences Case-Control Studies Child Child, Preschool Female Humans Infant Infant, Newborn Infection Infection - complications Influenza Vaccines Innate immunity Logistic Models Male Medical sciences Melanoma Melanoma - microbiology Melanoma - prevention & control Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Odds Ratio Risk Factors Skin Neoplasms - microbiology Skin Neoplasms - prevention & control Tumors Vaccination Vaccinia Vaccinia - complications |
| title | Impact of vaccinations and infectious diseases on the risk of melanoma—evaluation of an EORTC case–control study |
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