High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature
We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (A...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2003-11, Vol.15 (11), p.1229-1233 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Jalving, Mathilde Koornstra, Jan J Götz, Jan M van der Waaij, Laurens A de Jong, Steven Zwart, Nynke Karrenbeld, Arend Kleibeuker, Jan H |
| description | We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs. |
| doi_str_mv | 10.1097/00042737-200311000-00013 |
| format | Article |
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High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/00042737-200311000-00013</identifier><identifier>PMID: 14560158</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Aged ; Apoptosis ; beta Catenin ; Biological and medical sciences ; Carcinoma in Situ - complications ; Carcinoma in Situ - pathology ; Cell Nucleus - chemistry ; Cytoskeletal Proteins - analysis ; Gastric Fundus ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry - methods ; Male ; Medical sciences ; Polyps - complications ; Polyps - pathology ; Stomach Neoplasms - complications ; Stomach Neoplasms - pathology ; Trans-Activators - analysis</subject><ispartof>European journal of gastroenterology & hepatology, 2003-11, Vol.15 (11), p.1229-1233</ispartof><rights>2003 Lippincott Williams & Wilkins, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3313-f77e4239811a8a624705cac4218acfd49b3f48b37250764e52c1288608a7796b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15892530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14560158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jalving, Mathilde</creatorcontrib><creatorcontrib>Koornstra, Jan J</creatorcontrib><creatorcontrib>Götz, Jan M</creatorcontrib><creatorcontrib>van der Waaij, Laurens A</creatorcontrib><creatorcontrib>de Jong, Steven</creatorcontrib><creatorcontrib>Zwart, Nynke</creatorcontrib><creatorcontrib>Karrenbeld, Arend</creatorcontrib><creatorcontrib>Kleibeuker, Jan H</creatorcontrib><title>High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs.</description><subject>Aged</subject><subject>Apoptosis</subject><subject>beta Catenin</subject><subject>Biological and medical sciences</subject><subject>Carcinoma in Situ - complications</subject><subject>Carcinoma in Situ - pathology</subject><subject>Cell Nucleus - chemistry</subject><subject>Cytoskeletal Proteins - analysis</subject><subject>Gastric Fundus</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polyps - complications</subject><subject>Polyps - pathology</subject><subject>Stomach Neoplasms - complications</subject><subject>Stomach Neoplasms - pathology</subject><subject>Trans-Activators - analysis</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2P0zAQQC0EYsvCX0C-wC3g8UfscEMrYJFW4gISNzN1Jq3BbYKdUPXf49LCnjiMRmO_mbGeGeMgXoHo7GshhJZW2UYKoQBq2dQA9YCtQFvVmNbZh2wlOqObtoOvV-xJKd8rYRXYx-wKtGkFGLdi327jZttsMvbE-2OZEpaIPO55mcZ6GAMflv0pbRLuez6N6TiVNxx5wEI8U6VmfrrJ9CvSgY8Dn7fEU5wp47xkesoeDZgKPbvka_bl_bvPN7fN3acPH2_e3jVBKVDNYC1pqToHgA5bqa0wAYOW4DAMve7WatBuraw0wraajAwgnWuFQ2u7dq2u2cvz3CmPPxcqs9_FEijVZ9O4FG-hCnMSKujOYMhjKZkGP-W4w3z0IPzJrv9r1_-z6__Yra3PLzuW9Y76-8aLzgq8uABYAqYh4z7Ecs8Z10mjROX0mTuMqYoqP9JyoOy3hGne-v_9rvoNE5qQXg</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Jalving, Mathilde</creator><creator>Koornstra, Jan J</creator><creator>Götz, Jan M</creator><creator>van der Waaij, Laurens A</creator><creator>de Jong, Steven</creator><creator>Zwart, Nynke</creator><creator>Karrenbeld, Arend</creator><creator>Kleibeuker, Jan H</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200311</creationdate><title>High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature</title><author>Jalving, Mathilde ; Koornstra, Jan J ; Götz, Jan M ; van der Waaij, Laurens A ; de Jong, Steven ; Zwart, Nynke ; Karrenbeld, Arend ; Kleibeuker, Jan H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3313-f77e4239811a8a624705cac4218acfd49b3f48b37250764e52c1288608a7796b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Apoptosis</topic><topic>beta Catenin</topic><topic>Biological and medical sciences</topic><topic>Carcinoma in Situ - complications</topic><topic>Carcinoma in Situ - pathology</topic><topic>Cell Nucleus - chemistry</topic><topic>Cytoskeletal Proteins - analysis</topic><topic>Gastric Fundus</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polyps - complications</topic><topic>Polyps - pathology</topic><topic>Stomach Neoplasms - complications</topic><topic>Stomach Neoplasms - pathology</topic><topic>Trans-Activators - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jalving, Mathilde</creatorcontrib><creatorcontrib>Koornstra, Jan J</creatorcontrib><creatorcontrib>Götz, Jan M</creatorcontrib><creatorcontrib>van der Waaij, Laurens A</creatorcontrib><creatorcontrib>de Jong, Steven</creatorcontrib><creatorcontrib>Zwart, Nynke</creatorcontrib><creatorcontrib>Karrenbeld, Arend</creatorcontrib><creatorcontrib>Kleibeuker, Jan H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jalving, Mathilde</au><au>Koornstra, Jan J</au><au>Götz, Jan M</au><au>van der Waaij, Laurens A</au><au>de Jong, Steven</au><au>Zwart, Nynke</au><au>Karrenbeld, Arend</au><au>Kleibeuker, Jan H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2003-11</date><risdate>2003</risdate><volume>15</volume><issue>11</issue><spage>1229</spage><epage>1233</epage><pages>1229-1233</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>14560158</pmid><doi>10.1097/00042737-200311000-00013</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of gastroenterology & hepatology, 2003-11, Vol.15 (11), p.1229-1233 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Aged Apoptosis beta Catenin Biological and medical sciences Carcinoma in Situ - complications Carcinoma in Situ - pathology Cell Nucleus - chemistry Cytoskeletal Proteins - analysis Gastric Fundus Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry - methods Male Medical sciences Polyps - complications Polyps - pathology Stomach Neoplasms - complications Stomach Neoplasms - pathology Trans-Activators - analysis |
| title | High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature |
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