Inhibition of the translocated c-myc in Burkitt's Lymphoma by a PNA complementary to the Eμ enhancer

In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the E mu enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a spec...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-10, Vol.63 (19), p.6144-6148
Hauptverfasser:	CUTRONA, Giovanna, CARPANETO, Elisabetta M, PONZANELLI, Anna, ULIVI, Massimo, MILLO, Enrico, SCARFI, Sonia, RONCELLA, Silvio, BENATTI, Umberto, BOFFA, Lidia C, FERRARINI, Manlio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Burkitt Lymphoma - drug therapy Burkitt Lymphoma - genetics Burkitt Lymphoma - metabolism Cell Division - drug effects Cell Division - genetics Cell Line, Tumor Core Binding Factor Alpha 2 Subunit DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Down-Regulation - drug effects Down-Regulation - genetics Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genes, Immunoglobulin - genetics Genes, myc - drug effects Genes, myc - genetics Humans Medical sciences Peptide Nucleic Acids - genetics Peptide Nucleic Acids - pharmacology Pharmacology. Drug treatments Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Transcription, Genetic - drug effects Transcription, Genetic - genetics Translocation, Genetic Tumors
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