Inhibition of the translocated c-myc in Burkitt's Lymphoma by a PNA complementary to the Eμ enhancer
In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the E mu enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a spec...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2003-10, Vol.63 (19), p.6144-6148 |
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| creator | CUTRONA, Giovanna CARPANETO, Elisabetta M PONZANELLI, Anna ULIVI, Massimo MILLO, Enrico SCARFI, Sonia RONCELLA, Silvio BENATTI, Umberto BOFFA, Lidia C FERRARINI, Manlio |
| description | In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the E mu enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique E mu intronic sequence selectively blocked the expression of the c-myc oncogene under E mu control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications. |
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In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique E mu intronic sequence selectively blocked the expression of the c-myc oncogene under E mu control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 14559793</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antineoplastic agents ; Apoptosis - drug effects ; Apoptosis - genetics ; Biological and medical sciences ; Burkitt Lymphoma - drug therapy ; Burkitt Lymphoma - genetics ; Burkitt Lymphoma - metabolism ; Cell Division - drug effects ; Cell Division - genetics ; Cell Line, Tumor ; Core Binding Factor Alpha 2 Subunit ; DNA, Neoplasm - genetics ; DNA, Neoplasm - metabolism ; DNA-Binding Proteins - antagonists & inhibitors ; DNA-Binding Proteins - metabolism ; Down-Regulation - drug effects ; Down-Regulation - genetics ; Enhancer Elements, Genetic ; Gene Expression Regulation, Neoplastic - drug effects ; Gene Expression Regulation, Neoplastic - genetics ; Genes, Immunoglobulin - genetics ; Genes, myc - drug effects ; Genes, myc - genetics ; Humans ; Medical sciences ; Peptide Nucleic Acids - genetics ; Peptide Nucleic Acids - pharmacology ; Pharmacology. Drug treatments ; Proto-Oncogene Proteins - antagonists & inhibitors ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-ets ; Proto-Oncogene Proteins c-myc - antagonists & inhibitors ; Proto-Oncogene Proteins c-myc - biosynthesis ; Proto-Oncogene Proteins c-myc - genetics ; Transcription Factors - antagonists & inhibitors ; Transcription Factors - metabolism ; Transcription, Genetic - drug effects ; Transcription, Genetic - genetics ; Translocation, Genetic ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2003-10, Vol.63 (19), p.6144-6148</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15235108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14559793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUTRONA, Giovanna</creatorcontrib><creatorcontrib>CARPANETO, Elisabetta M</creatorcontrib><creatorcontrib>PONZANELLI, Anna</creatorcontrib><creatorcontrib>ULIVI, Massimo</creatorcontrib><creatorcontrib>MILLO, Enrico</creatorcontrib><creatorcontrib>SCARFI, Sonia</creatorcontrib><creatorcontrib>RONCELLA, Silvio</creatorcontrib><creatorcontrib>BENATTI, Umberto</creatorcontrib><creatorcontrib>BOFFA, Lidia C</creatorcontrib><creatorcontrib>FERRARINI, Manlio</creatorcontrib><title>Inhibition of the translocated c-myc in Burkitt's Lymphoma by a PNA complementary to the Eμ enhancer</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the E mu enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique E mu intronic sequence selectively blocked the expression of the c-myc oncogene under E mu control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications.</description><subject>Antineoplastic agents</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - genetics</subject><subject>Biological and medical sciences</subject><subject>Burkitt Lymphoma - drug therapy</subject><subject>Burkitt Lymphoma - genetics</subject><subject>Burkitt Lymphoma - metabolism</subject><subject>Cell Division - drug effects</subject><subject>Cell Division - genetics</subject><subject>Cell Line, Tumor</subject><subject>Core Binding Factor Alpha 2 Subunit</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - metabolism</subject><subject>DNA-Binding Proteins - antagonists & inhibitors</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Down-Regulation - drug effects</subject><subject>Down-Regulation - genetics</subject><subject>Enhancer Elements, Genetic</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Genes, Immunoglobulin - genetics</subject><subject>Genes, myc - drug effects</subject><subject>Genes, myc - genetics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Peptide Nucleic Acids - genetics</subject><subject>Peptide Nucleic Acids - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Proto-Oncogene Proteins - antagonists & inhibitors</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-ets</subject><subject>Proto-Oncogene Proteins c-myc - antagonists & inhibitors</subject><subject>Proto-Oncogene Proteins c-myc - biosynthesis</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Transcription Factors - antagonists & inhibitors</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic - drug effects</subject><subject>Transcription, Genetic - genetics</subject><subject>Translocation, Genetic</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1KxDAYRYMozjj6CpKNuirkp2na5TiMOjCoC12XNP1Ko01Sm3TRd_MZfCaLjri6XDhcLucILangeSLTVByjJSEkT0Qq2QKdhfA2V0GJOEULmgpRyIIvEexcayoTjXfYNzi2gOOgXOi8VhFqrBM7aWwcvh2HdxPjTcD7yfattwpXE1b4-XGNtbd9BxZcVMOEo_-Z2X59YnCtchqGc3TSqC7AxSFX6PVu-7J5SPZP97vNep_0jMuYpJpVXFIQAEw0OieqybmqpeZC0qzmhcw0K4SSVUEJI02ds0qzjBWQc8ppwVfo-ne3H_zHCCGW1gQNXacc-DGUkjLJBeEzeHkAx8pCXfaDsfP38k_MDFwdABW06prZiTbhnxOMzy5z_g1y5Gzv</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>CUTRONA, Giovanna</creator><creator>CARPANETO, Elisabetta M</creator><creator>PONZANELLI, Anna</creator><creator>ULIVI, Massimo</creator><creator>MILLO, Enrico</creator><creator>SCARFI, Sonia</creator><creator>RONCELLA, Silvio</creator><creator>BENATTI, Umberto</creator><creator>BOFFA, Lidia C</creator><creator>FERRARINI, Manlio</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Inhibition of the translocated c-myc in Burkitt's Lymphoma by a PNA complementary to the Eμ enhancer</title><author>CUTRONA, Giovanna ; CARPANETO, Elisabetta M ; PONZANELLI, Anna ; ULIVI, Massimo ; MILLO, Enrico ; SCARFI, Sonia ; RONCELLA, Silvio ; BENATTI, Umberto ; BOFFA, Lidia C ; FERRARINI, Manlio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-4c2b371e5ee25fc80af83ad7c35716d3976c295a7b91020fd82bc2629e8313193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antineoplastic agents</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - genetics</topic><topic>Biological and medical sciences</topic><topic>Burkitt Lymphoma - drug therapy</topic><topic>Burkitt Lymphoma - genetics</topic><topic>Burkitt Lymphoma - metabolism</topic><topic>Cell Division - drug effects</topic><topic>Cell Division - genetics</topic><topic>Cell Line, Tumor</topic><topic>Core Binding Factor Alpha 2 Subunit</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - metabolism</topic><topic>DNA-Binding Proteins - antagonists & inhibitors</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Down-Regulation - drug effects</topic><topic>Down-Regulation - genetics</topic><topic>Enhancer Elements, Genetic</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Genes, Immunoglobulin - genetics</topic><topic>Genes, myc - drug effects</topic><topic>Genes, myc - genetics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Peptide Nucleic Acids - genetics</topic><topic>Peptide Nucleic Acids - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proto-Oncogene Proteins - antagonists & inhibitors</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-ets</topic><topic>Proto-Oncogene Proteins c-myc - antagonists & inhibitors</topic><topic>Proto-Oncogene Proteins c-myc - biosynthesis</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><topic>Transcription Factors - antagonists & inhibitors</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic - drug effects</topic><topic>Transcription, Genetic - genetics</topic><topic>Translocation, Genetic</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUTRONA, Giovanna</creatorcontrib><creatorcontrib>CARPANETO, Elisabetta M</creatorcontrib><creatorcontrib>PONZANELLI, Anna</creatorcontrib><creatorcontrib>ULIVI, Massimo</creatorcontrib><creatorcontrib>MILLO, Enrico</creatorcontrib><creatorcontrib>SCARFI, Sonia</creatorcontrib><creatorcontrib>RONCELLA, Silvio</creatorcontrib><creatorcontrib>BENATTI, Umberto</creatorcontrib><creatorcontrib>BOFFA, Lidia C</creatorcontrib><creatorcontrib>FERRARINI, Manlio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUTRONA, Giovanna</au><au>CARPANETO, Elisabetta M</au><au>PONZANELLI, Anna</au><au>ULIVI, Massimo</au><au>MILLO, Enrico</au><au>SCARFI, Sonia</au><au>RONCELLA, Silvio</au><au>BENATTI, Umberto</au><au>BOFFA, Lidia C</au><au>FERRARINI, Manlio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of the translocated c-myc in Burkitt's Lymphoma by a PNA complementary to the Eμ enhancer</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>63</volume><issue>19</issue><spage>6144</spage><epage>6148</epage><pages>6144-6148</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the E mu enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique E mu intronic sequence selectively blocked the expression of the c-myc oncogene under E mu control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>14559793</pmid><tpages>5</tpages></addata></record> |
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| subjects | Antineoplastic agents Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Burkitt Lymphoma - drug therapy Burkitt Lymphoma - genetics Burkitt Lymphoma - metabolism Cell Division - drug effects Cell Division - genetics Cell Line, Tumor Core Binding Factor Alpha 2 Subunit DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Down-Regulation - drug effects Down-Regulation - genetics Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genes, Immunoglobulin - genetics Genes, myc - drug effects Genes, myc - genetics Humans Medical sciences Peptide Nucleic Acids - genetics Peptide Nucleic Acids - pharmacology Pharmacology. Drug treatments Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Transcription, Genetic - drug effects Transcription, Genetic - genetics Translocation, Genetic Tumors |
| title | Inhibition of the translocated c-myc in Burkitt's Lymphoma by a PNA complementary to the Eμ enhancer |
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