The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses
While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNγ from recent...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2000-07, Vol.13 (1), p.95-105 |
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| creator | Coyle, Anthony J Lehar, Sophie Lloyd, Clare Tian, Jane Delaney, Tracy Manning, Stephen Nguyen, Trang Burwell, Tim Schneider, Helga Gonzalo, Jose Angel Gosselin, Michael Owen, Laura Rudolph Rudd, Christopher E Gutierrez-Ramos, Jose Carlos |
| description | While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNγ from recently activated T cells and contributes to T cell–dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell–dependent immune responses. |
| doi_str_mv | 10.1016/S1074-7613(00)00011-X |
| format | Article |
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We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNγ from recently activated T cells and contributes to T cell–dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell–dependent immune responses.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10933398</pmid><doi>10.1016/S1074-7613(00)00011-X</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abatacept AIDS/HIV Animals Antigens, CD Antigens, Differentiation - immunology Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - immunology CD28 antigen CD28 Antigens - immunology Cloning, Molecular CTLA-4 Antigen Cytokines - biosynthesis Gene Expression Humans ICOS protein Immunoconjugates Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Inducible T-Cell Co-Stimulator Protein Jurkat Cells Male Mice Mice, Inbred BALB C Mice, Transgenic Signal Transduction Th1 Cells - immunology Th2 Cells - immunology |
| title | The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses |
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