Survival of children with AIDS: Experience in a university Hospital in Northeast Thailand
The survival experience of pediatric AIDS patients from three points: birth, age at first symptom and age at AIDS diagnosis (by the WHO definition) was studied. We had 90 subjects, 46 males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-acquired pediatric AI...
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Veröffentlicht in: | Journal of the Medical Association of Thailand 2000-06, Vol.83 (6), p.652-656 |
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description | The survival experience of pediatric AIDS patients from three points: birth, age at first symptom and age at AIDS diagnosis (by the WHO definition) was studied. We had 90 subjects, 46 males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-acquired pediatric AIDS. The children came to Srinagarind Hospital between January, 1989 and December, 1997. They were followed-up until April 30, 1998. Patients who did not come to the hospital were traced by confidential mail. The two most common first symptoms were chronic diarrhea (36.7%) and persistent lower respiratory tract infection (34.4%). The median age at the first symptom was four months (95% CI = 3 to 5 months) and the median age at diagnosis was 13 months (95% CI = 11 to 15 months). Thirty-nine cases received antiretroviral treatment, either AZT, ddI or both. Forty-five cases died, 18 cases lived to the end of the study, 27 could not be followed-up. A survival curve was calculated according to the Kaplan and Meier method using SPSS version 6.0. The 1- and 2-year survival rates from the time of the first symptom were 75.3 per cent (95% CI = 65.8% to 84.7%) and 60.3 per cent (95% CI = 49.0% to 71.6%). The corresponding survival rates from AIDS diagnosis were 59.7 per cent (95% CI = 48.4% to 71.1%) and 42.8% (95% CI = 30.3% to 55.3%), respectively. |
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We had 90 subjects, 46 males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-acquired pediatric AIDS. The children came to Srinagarind Hospital between January, 1989 and December, 1997. They were followed-up until April 30, 1998. Patients who did not come to the hospital were traced by confidential mail. The two most common first symptoms were chronic diarrhea (36.7%) and persistent lower respiratory tract infection (34.4%). The median age at the first symptom was four months (95% CI = 3 to 5 months) and the median age at diagnosis was 13 months (95% CI = 11 to 15 months). Thirty-nine cases received antiretroviral treatment, either AZT, ddI or both. Forty-five cases died, 18 cases lived to the end of the study, 27 could not be followed-up. A survival curve was calculated according to the Kaplan and Meier method using SPSS version 6.0. The 1- and 2-year survival rates from the time of the first symptom were 75.3 per cent (95% CI = 65.8% to 84.7%) and 60.3 per cent (95% CI = 49.0% to 71.6%). The corresponding survival rates from AIDS diagnosis were 59.7 per cent (95% CI = 48.4% to 71.1%) and 42.8% (95% CI = 30.3% to 55.3%), respectively.</description><identifier>ISSN: 0125-2208</identifier><identifier>PMID: 10932492</identifier><identifier>CODEN: JMTHBU</identifier><language>eng</language><publisher>Bangkok: Medical Association of Thailand</publisher><subject>Acquired Immunodeficiency Syndrome - diagnosis ; Acquired Immunodeficiency Syndrome - mortality ; Adolescent ; Age Distribution ; AIDS/HIV ; Biological and medical sciences ; Child ; Child, Preschool ; Confidence Intervals ; Data Collection ; Female ; Hospital Mortality - trends ; Hospitals, University ; Human viral diseases ; Humans ; Infant ; Infant, Newborn ; Infectious diseases ; Male ; Medical sciences ; Sex Distribution ; Survival Analysis ; Thailand - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Journal of the Medical Association of Thailand, 2000-06, Vol.83 (6), p.652-656</ispartof><rights>2003 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14453902$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10932492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LUMBIGANON, Pagakrong</creatorcontrib><creatorcontrib>KOSALARAKSA, Pope</creatorcontrib><creatorcontrib>LOAPAIBOON, Malinee</creatorcontrib><title>Survival of children with AIDS: Experience in a university Hospital in Northeast Thailand</title><title>Journal of the Medical Association of Thailand</title><addtitle>J Med Assoc Thai</addtitle><description>The survival experience of pediatric AIDS patients from three points: birth, age at first symptom and age at AIDS diagnosis (by the WHO definition) was studied. We had 90 subjects, 46 males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-acquired pediatric AIDS. The children came to Srinagarind Hospital between January, 1989 and December, 1997. They were followed-up until April 30, 1998. Patients who did not come to the hospital were traced by confidential mail. The two most common first symptoms were chronic diarrhea (36.7%) and persistent lower respiratory tract infection (34.4%). The median age at the first symptom was four months (95% CI = 3 to 5 months) and the median age at diagnosis was 13 months (95% CI = 11 to 15 months). Thirty-nine cases received antiretroviral treatment, either AZT, ddI or both. Forty-five cases died, 18 cases lived to the end of the study, 27 could not be followed-up. A survival curve was calculated according to the Kaplan and Meier method using SPSS version 6.0. The 1- and 2-year survival rates from the time of the first symptom were 75.3 per cent (95% CI = 65.8% to 84.7%) and 60.3 per cent (95% CI = 49.0% to 71.6%). The corresponding survival rates from AIDS diagnosis were 59.7 per cent (95% CI = 48.4% to 71.1%) and 42.8% (95% CI = 30.3% to 55.3%), respectively.</description><subject>Acquired Immunodeficiency Syndrome - diagnosis</subject><subject>Acquired Immunodeficiency Syndrome - mortality</subject><subject>Adolescent</subject><subject>Age Distribution</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Confidence Intervals</subject><subject>Data Collection</subject><subject>Female</subject><subject>Hospital Mortality - trends</subject><subject>Hospitals, University</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Sex Distribution</subject><subject>Survival Analysis</subject><subject>Thailand - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0125-2208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0D1PwzAQBmAPIFoKfwF5gS2SYzuJzVaVQitVMDQLU3R2HMUoX9hOoP-eSBQx3fA-7-l0F2hJYppElBKxQNfefxDCE5myK7SIiWSUS7pE78fRTXaCBvcV1rVtSmc6_GVDjdf7p-Mj3n4PxlnTaYNthwGPnZ2M8zac8K73gw1zdQ5eexdqAz7gvAbbQFfeoMsKGm9uz3OF8udtvtlFh7eX_WZ9iIY4oSGSiRKpYhzitMoUJSCJEJxkWpOEKEiV5ESVulSCp3OmmWDEaEaZVqJSgq3Qw-_awfWfo_GhaK3XpplPMP3oiyymGYspneHdGY6qNWUxONuCOxV_v5jB_RmA19BUDjpt_b_jPGGSUPYDlJlmlQ</recordid><startdate>200006</startdate><enddate>200006</enddate><creator>LUMBIGANON, Pagakrong</creator><creator>KOSALARAKSA, Pope</creator><creator>LOAPAIBOON, Malinee</creator><general>Medical Association of Thailand</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200006</creationdate><title>Survival of children with AIDS: Experience in a university Hospital in Northeast Thailand</title><author>LUMBIGANON, Pagakrong ; KOSALARAKSA, Pope ; LOAPAIBOON, Malinee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p152t-95b86b34a16f7b20a9088407cc050ba6b940bdcdb846a90c3830ec323cb8fb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acquired Immunodeficiency Syndrome - diagnosis</topic><topic>Acquired Immunodeficiency Syndrome - mortality</topic><topic>Adolescent</topic><topic>Age Distribution</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Confidence Intervals</topic><topic>Data Collection</topic><topic>Female</topic><topic>Hospital Mortality - trends</topic><topic>Hospitals, University</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Sex Distribution</topic><topic>Survival Analysis</topic><topic>Thailand - epidemiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>online_resources</toplevel><creatorcontrib>LUMBIGANON, Pagakrong</creatorcontrib><creatorcontrib>KOSALARAKSA, Pope</creatorcontrib><creatorcontrib>LOAPAIBOON, Malinee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Medical Association of Thailand</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LUMBIGANON, Pagakrong</au><au>KOSALARAKSA, Pope</au><au>LOAPAIBOON, Malinee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of children with AIDS: Experience in a university Hospital in Northeast Thailand</atitle><jtitle>Journal of the Medical Association of Thailand</jtitle><addtitle>J Med Assoc Thai</addtitle><date>2000-06</date><risdate>2000</risdate><volume>83</volume><issue>6</issue><spage>652</spage><epage>656</epage><pages>652-656</pages><issn>0125-2208</issn><coden>JMTHBU</coden><abstract>The survival experience of pediatric AIDS patients from three points: birth, age at first symptom and age at AIDS diagnosis (by the WHO definition) was studied. We had 90 subjects, 46 males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-acquired pediatric AIDS. The children came to Srinagarind Hospital between January, 1989 and December, 1997. They were followed-up until April 30, 1998. Patients who did not come to the hospital were traced by confidential mail. The two most common first symptoms were chronic diarrhea (36.7%) and persistent lower respiratory tract infection (34.4%). The median age at the first symptom was four months (95% CI = 3 to 5 months) and the median age at diagnosis was 13 months (95% CI = 11 to 15 months). Thirty-nine cases received antiretroviral treatment, either AZT, ddI or both. Forty-five cases died, 18 cases lived to the end of the study, 27 could not be followed-up. A survival curve was calculated according to the Kaplan and Meier method using SPSS version 6.0. The 1- and 2-year survival rates from the time of the first symptom were 75.3 per cent (95% CI = 65.8% to 84.7%) and 60.3 per cent (95% CI = 49.0% to 71.6%). The corresponding survival rates from AIDS diagnosis were 59.7 per cent (95% CI = 48.4% to 71.1%) and 42.8% (95% CI = 30.3% to 55.3%), respectively.</abstract><cop>Bangkok</cop><pub>Medical Association of Thailand</pub><pmid>10932492</pmid><tpages>5</tpages></addata></record> |
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subjects | Acquired Immunodeficiency Syndrome - diagnosis Acquired Immunodeficiency Syndrome - mortality Adolescent Age Distribution AIDS/HIV Biological and medical sciences Child Child, Preschool Confidence Intervals Data Collection Female Hospital Mortality - trends Hospitals, University Human viral diseases Humans Infant Infant, Newborn Infectious diseases Male Medical sciences Sex Distribution Survival Analysis Thailand - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
title | Survival of children with AIDS: Experience in a university Hospital in Northeast Thailand |
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