The Involvement of Tyrosine Kinases, Cyclic AMP/Protein Kinase A, and p38 Mitogen-Activated Protein Kinase in IL-13-Mediated Arginase I Induction in Macrophages: Its Implications in IL-13-Inhibited Nitric Oxide Production

In macrophages, L-arginine can be used by NO synthase and arginase to form NO and urea, respectively. Therefore, activation of arginase may be an effective mechanism for regulating NO production in macrophages through substrate competition. Here, we examined whether IL-13 up-regulates arginase and t...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-08, Vol.165 (4), p.2134-2141
Hauptverfasser:	Chang, Chiung-I, Zoghi, Behyar, Liao, James C, Kuo, Lih
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginase - biosynthesis Arginase - metabolism Benzoquinones Cell Line Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - physiology Dexamethasone - pharmacology Enzyme Activation - drug effects Enzyme Activation - immunology Enzyme Induction - immunology Enzyme Inhibitors - pharmacology Genistein - pharmacology Imidazoles - pharmacology Interleukin-13 - physiology Intracellular Fluid - metabolism Lactams, Macrocyclic Macrophages - enzymology Macrophages - metabolism Mice Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - physiology Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis p38 Mitogen-Activated Protein Kinases p38 protein Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - physiology Pyridines - pharmacology Quinones - pharmacology Rifabutin - analogs & derivatives RNA, Messenger - biosynthesis
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