Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin

Inhibition of angiogenesis has emerged as a key focus for the treatment of cancer, necessitating a better understanding of the downstream molecular targets of angiogenesis inhibitors. Endostatin, thrombospondin-1, fumagillin, and its synthetic derivative, TNP-470, are potent inhibitors of endothelia...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-10, Vol.63 (19), p.6405-6412
Hauptverfasser:	KEEZER, Susan M, IVIE, Susan E, KRUTZSCH, Henry C, TANDLE, Anita, LIBUTTI, Steven K, ROBERTS, David D
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Actin Cytoskeleton - metabolism Actin Depolymerizing Factors Angiogenesis Inhibitors - pharmacology Antineoplastic agents Biological and medical sciences Cell Adhesion - drug effects Cell Movement - drug effects Cells, Cultured Cyclohexanes Cytokines - pharmacology Cytoskeletal Proteins - metabolism Cytoskeleton - drug effects Cytoskeleton - metabolism Endostatins - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Fatty Acids, Unsaturated - pharmacology Heat-Shock Proteins - metabolism Humans Medical sciences Microfilament Proteins - metabolism Neoplasm Proteins - pharmacology Pharmacology. Drug treatments Phosphorylation - drug effects RNA-Binding Proteins - pharmacology Sesquiterpenes - pharmacology Subcellular Fractions - metabolism Thrombospondin 1 - pharmacology Tumors
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