Interferon-gamma increases IL-12 mRNA expression and attentuates allergic late-onset airway responses in the Brown Norway rat

Interferon gamma is a T-helper cell (Th)-1-type cytokine that has been suggested to inhibit the development of an atopic Th2-type profile of cytokine expression. The aim of this study was to investigated the effect of exogenous rat interferon gamma on antigen-induced airway responses, and on Th1 and...

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Veröffentlicht in:	The European respiratory journal 2000-07, Vol.16 (1), p.22-29
Hauptverfasser:	Isogai, S, Hamid, Q, Minshall, E, Miyake, S, Yoshizawa, Y, Taha, R, Toda, M, Martin, JG, Watanabe, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Resistance Allergic diseases Animals Antigens Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Immunopathology In Situ Hybridization Interferon-gamma - pharmacology Interferon-gamma - physiology Interleukin-12 - analysis Interleukin-12 - biosynthesis Interleukin-4 - analysis Interleukin-5 - analysis Male Medical sciences Ovalbumin Rats Rats, Inbred BN Respiratory and ent allergic diseases Respiratory Hypersensitivity - metabolism Respiratory Hypersensitivity - physiopathology RNA, Messenger - analysis RNA, Messenger - biosynthesis
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