Dynamic changes of NADH fluorescence images and NADH content during spreading depression in the cerebral cortex of gerbils

To elucidate the changes in the mitochondrial redox state during spreading depression (SD), tissue NADH content was measured in 20 anesthetized gerbils by the enzymatic cycling assay in a small cortical region (0.30±0.07 mg) where the direct-current (DC)-potential was measured. Sequential imaging of...

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Veröffentlicht in:	Brain research 2000-07, Vol.872 (1), p.294-300
Hauptverfasser:	Hashimoto, Megumi, Takeda, Yoshimasa, Sato, Tetsufumi, Kawahara, Hidero, Nagano, Osamu, Hirakawa, Masahisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Flow Velocity - physiology Brain Chemistry - drug effects Brain Chemistry - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Cortex - blood supply Cerebral Cortex - chemistry Cerebral Cortex - metabolism Cerebrovascular Circulation - physiology Cortical Spreading Depression - physiology Extracellular direct-current (DC) potential Fluorescence Fundamental and applied biological sciences. Psychology Gerbillinae Laser-Doppler Flowmetry Male Membrane Potentials - physiology Mitochondria - metabolism Mitochondrial redox state Mongolian gerbil NAD NAD - analysis NAD - metabolism NAD - radiation effects NADH fluorescence image Oxidation-Reduction Potassium Chloride - pharmacology Reaction Time - physiology Regional cerebral blood flow (regional CBF) repolarization Spreading depression Stimulation, Chemical Ultraviolet Rays Vertebrates: nervous system and sense organs Video Recording - methods
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